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 "excerpt": "Anastomotic urethroplasty, also called excision and primary anastomosis (EPA), treats urethral stricture by cutting out the narrowed segment and joining the healthy urethral ends without tension.",
 "snippet": "Anastomotic urethroplasty, also called excision and primary anastomosis (EPA), treats urethral stricture by cutting out the narrowed segment and joining the healthy urethral ends without tension.",
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 "markdown": "# Anastomotic urethroplasty\n\nAnastomotic urethroplasty, also called excision and primary anastomosis (EPA), is a surgical technique that treats a urethral stricture by cutting out the narrowed segment and joining the two healthy ends of the urethra in a tension-free, spatulated (cut lengthwise and widened into a spoon shape) end-to-end anastomosis. It is the standard definitive repair for short bulbar strictures, with success often above 90% in published series.<sup>[1](https://drallenmorey.com/wp-content/uploads/2023/04/Contemporary-Techniques-and-Outcomes.pdf)</sup> European guidelines state the operative requirement directly: the anastomosis must be made between healthy urethral ends and without any tension.<sup>[2](https://d56bochluxqnz.cloudfront.net/documents/full-guideline/EAU-Guidelines-on-Urethral-Strictures-2023.pdf)</sup>\n\n| Key fact | Detail |\n|---|---|\n| What the operation produces | Excision of the scarred segment with a tension-free, spatulated end-to-end anastomosis of healthy urethral ends <sup>[1](https://drallenmorey.com/wp-content/uploads/2023/04/Contemporary-Techniques-and-Outcomes.pdf)</sup><sup> • </sup><sup>[2](https://d56bochluxqnz.cloudfront.net/documents/full-guideline/EAU-Guidelines-on-Urethral-Strictures-2023.pdf)</sup> |\n| Main indication | Short bulbar strictures; anastomotic repair has its greatest success in bulbar and penobulbar disease <sup>[3](https://www.sciencedirect.com/science/article/abs/pii/S0090429521008426)</sup> |\n| Success rate | Greater than 93% pooled across 17 series and 1234 patients; 89.7% in a systematic review of anterior urethroplasty <sup>[1](https://drallenmorey.com/wp-content/uploads/2023/04/Contemporary-Techniques-and-Outcomes.pdf)</sup><sup> • </sup><sup>[3](https://www.sciencedirect.com/science/article/abs/pii/S0090429521008426)</sup> |\n| Length limit | About 2 cm customary in the distal bulb; up to 5 cm possible in the proximal bulb in selected favorable cases <sup>[4](https://pmc.ncbi.nlm.nih.gov/articles/PMC5066880/)</sup> |\n| Sexual complications | 9.9% adverse sexual-function change, including 6.4% erectile dysfunction, in a 171-patient bulbar series <sup>[5](https://www.auajournals.org/doi/10.1016/j.juro.2017.02.1524)</sup> |\n| Versus endoscopic treatment | Urethroplasty succeeds in 80-95% long term, versus 35-70% for dilation or direct vision internal urethrotomy in short strictures <sup>[6](https://www.auanet.org/documents/Guidelines/Archive/Urethral%20Stricture%20Disease%20Unabridged%20FINAL%20060923.pdf)</sup> |\n\n## How it works\n\nA male urethral stricture is a narrowed segment of the anterior urethra caused by fibrosis of the mucosa and the surrounding corpus spongiosum, a process called spongiofibrosis.<sup>[2](https://d56bochluxqnz.cloudfront.net/documents/full-guideline/EAU-Guidelines-on-Urethral-Strictures-2023.pdf)</sup> Because the disease lives in the tissue itself, dilation or incision leaves scar in place, while anastomotic urethroplasty removes it: the stricture and its scarred spongiosum are excised, and the two remaining ends, which must be free of scarring, are sewn together without significant tension.<sup>[7](https://www.urology-textbook.com/anastomotic-urethroplasty.html)</sup> This is why excision is preferred over tissue transfer for short strictures: a graft or flap needs a well-vascularized bed.<sup>[2](https://d56bochluxqnz.cloudfront.net/documents/full-guideline/EAU-Guidelines-on-Urethral-Strictures-2023.pdf)</sup>\n\nThe geometry costs length. Both ends are spatulated about 1 cm on each side, so a 1 cm stricture requires removal of roughly 3 cm of urethra.<sup>[8](https://www.scielo.br/j/ibju/a/jYRV6zBgFk37wxS7GQ6hfZw/?format=pdf&lang=en)</sup> The male urethra is exceptionally extensible, and mobilization can yield an additional 65% of length; up to 5 cm of resection is possible in the proximal bulb in selected cases, while a 2 cm limit is more customary in the distal bulb.<sup>[4](https://pmc.ncbi.nlm.nih.gov/articles/PMC5066880/)</sup> The closer the stricture sits to the membranous urethra, the longer the repair can be.<sup>[7](https://www.urology-textbook.com/anastomotic-urethroplasty.html)</sup> Published reviews attribute failure to two mechanisms: inadequate excision of the stricture, and incomplete mobilization with excessive anastomotic tension.<sup>[9](https://www.sciencedirect.com/science/article/abs/pii/S0094014302000356)</sup>\n\n## How it is done\n\n**Preoperative staging.** [Evaluation](https://www.edgepedia.org/evaluation) includes a focused genitourinary history, a patient-reported outcome index, uroflowmetry, post-void residual, urinalysis, retrograde [urethrography](https://www.edgepedia.org/urethrography) (RUG) with or without voiding [cystourethrography](https://www.edgepedia.org/cystourethrography), and cystourethroscopy to assess tissue quality and rule out malignancy.<sup>[10](https://pmc.ncbi.nlm.nih.gov/articles/PMC9740840/)</sup> The surgeon stages the stricture by length, lumen, and location; patients managed with catheters receive a suprapubic catheter to allow urethral rest before repair.<sup>[10](https://pmc.ncbi.nlm.nih.gov/articles/PMC9740840/)</sup>\n\n**Operative steps.** The patient is placed in simple lithotomy with Allen stirrups and sequential inflatable compression sleeves, under general anesthesia with controlled hypotension to limit bleeding, and a 3 Fr guidewire is passed through the urethra before repair.<sup>[8](https://www.scielo.br/j/ibju/a/jYRV6zBgFk37wxS7GQ6hfZw/?format=pdf&lang=en)</sup> Through a midline perineal incision, the [bulbospongiosus muscle](https://www.edgepedia.org/bulbospongiosus-muscle) is exposed via Gallaudet's fascia, a Turner-Warwick self-retaining ring retractor provides exposure, and the bulbar urethra is mobilized dorsally off the tunica albuginea while preserving the main bulbar arteries.<sup>[11](https://pmc.ncbi.nlm.nih.gov/articles/PMC4708276/)</sup> Mid-bulbar and distal bulbar strictures can be reached by retracting the bulbospongiosus inferiorly rather than incising it.<sup>[12](https://onlinelibrary.wiley.com/doi/10.1002/9781119524328.ch57)</sup> The stricture is excised until both ends are scar-free, the ends are spatulated 180 degrees apart, an 18-20 CH transurethral catheter is inserted, and the anastomosis is sutured with interrupted PDS 4-0 stitches.<sup>[7](https://www.urology-textbook.com/anastomotic-urethroplasty.html)</sup> For long posterior defects (greater than 2.5 cm), tension-free closure is achieved with urethral mobilization, inferior or posterior pubectomy, and subcrural urethral rerouting.<sup>[13](https://tau.amegroups.org/article/view/144674/html)</sup>\n\n## Origin\n\nThe excisional principle long predates modern graft-based reconstruction. Historical reviews trace stricture excision with a sutured anastomosis to late 19th-century surgery and note that the technique gained widespread recognition only in the mid-1980s.<sup>[14](https://www.elsevier.es/en-revista-actas-urologicas-espanolas-english-392-pdf-download-S217357862400129X?newsletter=true)</sup> The earliest indexed papers in the technique's family concern its variants: the grafting era of ventral buccal mucosal repair was addressed by Allen F. Morey and Jack W. McAninch in 1996 in Urology,<sup>[15](https://doi.org/10.1016/s0090-4295%2896%2900154-9)</sup> and the augmented anastomotic variant was reported by Michael L. Guralnick and George D. Webster in 2001 in The Journal of Urology.<sup>[16](https://doi.org/10.1016/s0022-5347%2805%2966335-5)</sup>\n\n## Variants\n\n**Non-transecting and vessel-sparing repair.** A vessel-sparing modification preserves the urethral blood supply: the bulbar arteries are mobilized and spared, and the corpus spongiosum is reconstituted over the anastomosis.<sup>[11](https://pmc.ncbi.nlm.nih.gov/articles/PMC4708276/)</sup> For strictures of 1 to 3 cm without dense spongiofibrosis, in which a guidewire passes a lumen wider than 4 mm, the scarred segment can be removed while the healthy ventral spongiosal part is left intact.<sup>[17](https://journals.lww.com/ursc/fulltext/2024/12000/the_outcome_of_nontransecting_anastomotic.7.aspx)</sup>\n\n**Augmented anastomotic urethroplasty** combines excision with an onlay graft for strictures not amenable to either technique alone; Guralnick and Webster reported it in 2001 with a 93% stricture-free rate at a mean follow-up of 28 months in 29 patients.<sup>[16](https://doi.org/10.1016/s0022-5347%2805%2966335-5)</sup><sup> • </sup><sup>[18](https://onlinelibrary.wiley.com/doi/10.1111/iju.13356)</sup> **Two-sided dorsal plus ventral oral grafting** was reported by Enzo Palminteri and colleagues in 2015,<sup>[19](https://doi.org/10.1016/j.urology.2015.01.013)</sup> achieving a stricture-free rate of 89.8% at a median follow-up of 47 months while avoiding transection.<sup>[18](https://onlinelibrary.wiley.com/doi/10.1111/iju.13356)</sup> **MANTA**, a ventral mucomucosal non-transecting augmentation for obliterative strictures, was described by Phillip Marks and colleagues in 2023.<sup>[20](https://doi.org/10.1111/bju.16112)</sup> For posterior disease, the bulboprostatic anastomosis is the corresponding end-to-end form.<sup>[21](https://www.scilit.com/publications/a2831699273e6c98de15bf46a6fe5d85)</sup>\n\n## Applications\n\nIn selected bulbar populations, success is consistently high. One series of 171 anastomotic bulbar repairs (mean stricture length 1.5 cm) reported 98.2% success, defined as urethral patency greater than 16 Fr on cystoscopy, at a mean follow-up of 74.9 months.<sup>[5](https://www.auajournals.org/doi/10.1016/j.juro.2017.02.1524)</sup> Another series of 348 patients (mean length 2.1 cm, mean follow-up 39.4 months) reported 93.4% success, defined as absence of additional urethral instrumentation.<sup>[4](https://pmc.ncbi.nlm.nih.gov/articles/PMC5066880/)</sup> A systematic review found excision and primary anastomosis had the highest success of any anterior urethroplasty method, 89.7%, versus 86.5% for free graft and 76% for pedicled flap repair, though it involved the shortest strictures (median 2.1 cm).<sup>[3](https://www.sciencedirect.com/science/article/abs/pii/S0090429521008426)</sup>\n\nGuidelines reflect this gap. The AUA recommends urethroplasty as initial treatment for bulbar strictures of 2 cm or longer, given the low success of [urethrotomy](https://www.edgepedia.org/urethrotomy) or dilation.<sup>[6](https://www.auanet.org/documents/Guidelines/Archive/Urethral%20Stricture%20Disease%20Unabridged%20FINAL%20060923.pdf)</sup> In the OPEN trial, urethroplasty carried a 48% reduced risk of reintervention versus urethrotomy (HR 0.52; 95% CI 0.31-0.89), with recurrence in 19% versus 39%.<sup>[22](https://doi.org/10.1016/j.eururo.2020.06.003)</sup> A Scandinavian multicenter randomized trial compared excision and primary anastomosis with buccal mucosal grafting directly.<sup>[23](https://doi.org/10.1016/j.eururo.2021.12.017)</sup>\n\n## Limitations and alternatives\n\n**Length limits are contested.** One review holds that EPA cannot be performed for strictures longer than 20 mm because a tension-free anastomosis becomes difficult.<sup>[24](https://pmc.ncbi.nlm.nih.gov/articles/PMC7292066/)</sup> Others report successful repair of proximal bulbar strictures up to 5 cm in favorable cases.<sup>[4](https://pmc.ncbi.nlm.nih.gov/articles/PMC5066880/)</sup>\n\n**Complications.** In bulbar disease, adverse sexual-function change affects about 10% of patients (6.4% erectile dysfunction in the 171-patient series).<sup>[5](https://www.auajournals.org/doi/10.1016/j.juro.2017.02.1524)</sup> Urethral transection for short bulbar strictures has been linked to 18% to 22.5% sexual dysfunction and ejaculation disorders compared with stricturotomy and augmented repair.<sup>[17](https://journals.lww.com/ursc/fulltext/2024/12000/the_outcome_of_nontransecting_anastomotic.7.aspx)</sup> In traumatic and posterior disease the picture differs: erectile dysfunction is reported up to 50%, often attributable to the pelvic fracture itself, stress incontinence under 10%, and penile shortening up to 30%.<sup>[25](https://openurologyandnephrologyjournal.com/VOLUME/17/ELOCATOR/e1874303X316281/FULLTEXT/)</sup> Erectile decline is significantly higher at three months after anastomotic repair but shows no difference versus other techniques at six months and beyond.<sup>[4](https://pmc.ncbi.nlm.nih.gov/articles/PMC5066880/)</sup>\n\n**Failure modes and management.** Success falls in adverse populations: a 23-year single-center study achieved only 66.7% success, with 16 of 17 failures in patients who had undergone a mean of 2.4 failed hypospadias repairs or prior dilation or urethroplasty.<sup>[26](https://www.dovepress.com/surgical-management-of-anterior-urethral-stricture-a-23-year-single-ce-peer-reviewed-fulltext-article-RRU)</sup> Traumatic strictures restricture in 36% overall and 45.2% in the posterior urethra.<sup>[25](https://openurologyandnephrologyjournal.com/VOLUME/17/ELOCATOR/e1874303X316281/FULLTEXT/)</sup> Failed repairs can be reconstructed again: in a tertiary series, repeat EPA succeeded in 95% of patients after failed primary EPA and 94% after failed substitution repair.<sup>[1](https://drallenmorey.com/wp-content/uploads/2023/04/Contemporary-Techniques-and-Outcomes.pdf)</sup> Short recurrences after urethroplasty can be managed with direct vision internal urethrotomy,<sup>[27](https://doi.org/10.1016/j.eururo.2026.04.021)</sup> and a paclitaxel-coated balloon catheter achieved freedom from intervention at 1 year in 83.2% versus 21.7% for urethrotomy or dilation alone in recurrent anterior strictures under 3 cm.<sup>[28](https://doi.org/10.1002/bco2.312)</sup> For posterior stenosis, robot-assisted vesicourethral anastomotic reconstruction shows high success in complex cases,<sup>[13](https://tau.amegroups.org/article/view/144674/html)</sup> and a preliminary comparison of non-transecting anastomotic urethroplasty versus EPA found 100% versus 86.7% surgical success (\\( p = 0.14 \\)) with better continence outcomes in patients with a preserved bladder neck.<sup>[29](https://doi.org/10.1111/iju.70073)</sup> For short bulbar strictures, non-transecting substitution repair produces fewer penile complications than transecting repair with no difference in erectile function at 12 months.<sup>[6](https://www.auanet.org/documents/Guidelines/Archive/Urethral%20Stricture%20Disease%20Unabridged%20FINAL%20060923.pdf)</sup>\n\n## References\n\n1. [Urethroplasty for Stricture Disease: Contemporary Techniques and Outcomes (Morey)](https://drallenmorey.com/wp-content/uploads/2023/04/Contemporary-Techniques-and-Outcomes.pdf)\n2. [EAU Guidelines on Urethral Strictures - Limited Update 2023](https://d56bochluxqnz.cloudfront.net/documents/full-guideline/EAU-Guidelines-on-Urethral-Strictures-2023.pdf)\n3. [Anterior Urethroplasty for the Management of Urethral Strictures in Males: A Systematic Review](https://www.sciencedirect.com/science/article/abs/pii/S0090429521008426)\n4. [The case for excision and primary anastomotic urethroplasty for bulbar urethral stricture (Siegel & Morey, Int Braz J Urol 2016)](https://pmc.ncbi.nlm.nih.gov/articles/PMC5066880/)\n5. [PD34-01 Anastomotic Bulbar Urethroplasty: To Transect or Not to Transect? (Chapman et al., J Urol 2017)](https://www.auajournals.org/doi/10.1016/j.juro.2017.02.1524)\n6. [Urethral Stricture Disease: AUA Guideline (Published 2016; Amended 2023)](https://www.auanet.org/documents/Guidelines/Archive/Urethral%20Stricture%20Disease%20Unabridged%20FINAL%20060923.pdf)\n7. [Anastomotic Urethroplasty: Surgical Technique and Complications (Urology Textbook)](https://www.urology-textbook.com/anastomotic-urethroplasty.html)\n8. [Surgical treatment of bulbar urethral strictures: tips and tricks (International Braz J Urol)](https://www.scielo.br/j/ibju/a/jYRV6zBgFk37wxS7GQ6hfZw/?format=pdf&lang=en)\n9. [Excision and primary anastomosis for anterior urethral stricture](https://www.sciencedirect.com/science/article/abs/pii/S0094014302000356)\n10. [Non-Transecting Urethroplasty for Bulbar Urethral Strictures, Narrative Review and Treatment Algorithm](https://pmc.ncbi.nlm.nih.gov/articles/PMC9740840/)\n11. [Non-transecting bulbar urethroplasty (Translational Andrology and Urology)](https://pmc.ncbi.nlm.nih.gov/articles/PMC4708276/)\n12. [Operative Dictations in Urologic Surgery (chapter 57, Wiley)](https://onlinelibrary.wiley.com/doi/10.1002/9781119524328.ch57)\n13. [Robot-assisted reconstruction of posterior urethral stenosis: surgical techniques, graft use, and clinical outcomes (Vereecken et al., Translational Andrology and Urology, 2025)](https://tau.amegroups.org/article/view/144674/html)\n14. [Pioneering Urethral Reconstruction for the Treatment of Strictures: From Early Beginnings to Recent History (Actas Urológicas Españolas, 2024)](https://www.elsevier.es/en-revista-actas-urologicas-espanolas-english-392-pdf-download-S217357862400129X?newsletter=true)\n15. [When and how to use buccal mucosal grafts in adult bulbar urethroplasty (Urology, 1996)](https://doi.org/10.1016/s0090-4295%2896%2900154-9)\n16. [THE AUGMENTED ANASTOMOTIC URETHROPLASTY: INDICATIONS AND OUTCOME IN 29 PATIENTS (The Journal of Urology, 2001)](https://doi.org/10.1016/s0022-5347%2805%2966335-5)\n17. [The outcome of nontransecting anastomotic urethroplasty in recurrent bulbar urethral stricture and its impact on sexual functions: A prospective observational study (2024)](https://journals.lww.com/ursc/fulltext/2024/12000/the_outcome_of_nontransecting_anastomotic.7.aspx)\n18. [Substitution urethroplasty using oral mucosa graft for male anterior urethral stricture disease: Current topics and reviews (International Journal of Urology)](https://onlinelibrary.wiley.com/doi/10.1111/iju.13356)\n19. [Enzo Palminteri and colleagues (2015). Two-sided Dorsal Plus Ventral Oral Graft Bulbar Urethroplasty: Long-term Results and Predictive Factors. Urology.](https://doi.org/10.1016/j.urology.2015.01.013)\n20. [Phillip Marks and colleagues (2023). Mucomucosal anastomotic non‐transecting augmentation (MANTA) urethroplasty: a ventral modification for obliterative strictures. British Journal of Urology.](https://doi.org/10.1111/bju.16112)\n21. [Long-term outcomes of the excision and primary anastomotic urethroplasty in non-traumatic bulbar and membranous urethral strictures (Kayigil, Okulu et al., 2023-2024)](https://www.scilit.com/publications/a2831699273e6c98de15bf46a6fe5d85)\n22. [Beatriz Goulao and colleagues (2020). Surgical Treatment for Recurrent Bulbar Urethral Stricture: A Randomised Open-label Superiority Trial of Open Urethroplasty Versus Endoscopic Urethrotomy (the OPEN Trial). European Urology.](https://doi.org/10.1016/j.eururo.2020.06.003)\n23. [Ole Jacob Nilsen and colleagues (2022). To Transect or Not Transect: Results from the Scandinavian Urethroplasty Study, A Multicentre Randomised Study of Bulbar Urethroplasty Comparing Excision and Primary Anastomosis Versus Buccal Mucosal Grafting. European Urology.](https://doi.org/10.1016/j.eururo.2021.12.017)\n24. [Complicated bulbar urethral stricture successfully treated using augmented anastomotic urethroplasty: A case report (IJU Case Reports)](https://pmc.ncbi.nlm.nih.gov/articles/PMC7292066/)\n25. [End-to-End Anastomotic Urethroplasty Outcome in Anterior and Posterior Traumatic Urethral Stricture: A Single-Center Experience](https://openurologyandnephrologyjournal.com/VOLUME/17/ELOCATOR/e1874303X316281/FULLTEXT/)\n26. [Surgical management of anterior urethral stricture: a 23-year single-center retrospective study (Guo et al., 2024)](https://www.dovepress.com/surgical-management-of-anterior-urethral-stricture-a-23-year-single-ce-peer-reviewed-fulltext-article-RRU)\n27. [European Association of Urology Guidelines on Urethral Strictures: Summary of the 2026 Guidelines](https://doi.org/10.1016/j.eururo.2026.04.021)\n28. [Maia E. VanDyke and colleagues (2023). Optilume drug‐coated balloon for anterior urethral stricture: 2‐year results of the ROBUST III trial. BJUI Compass.](https://doi.org/10.1002/bco2.312)\n29. [Non-Transecting Anastomotic Urethroplasty Versus Excision and Primary Anastomosis for Non-Traumatic Posterior Urethral Stenosis: A Preliminary Feasibility Study](https://doi.org/10.1111/iju.70073)\n\n---\n*Topic: Encyclopedia › Life and health › Human health and medicine › Clinical assessment and procedures › Surgery and surgical specialties › Urologic surgery procedures*\n\n*Initially written Sep 29, 2026 · Edited: Oct 15, 2026; Oct 25, 2026*\n\n*Copyright 2026 EdgeChat AI, a subsidiary of Biostate AI.*\n\nLicense: Edgepedia Community License 1.0, https://www.edgepedia.org/edgepedia/license\n",
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 "speakable": "Anastomotic urethroplasty, also called excision and primary anastomosis, treats urethral stricture by cutting out the narrowed segment and joining the healthy urethral ends without tension."
}
