{ "id": "epexdj7282", "slug": "balloon-angioplasty", "title": "Balloon angioplasty", "updated": "2026-10-15", "topic_path": [ { "id": "life", "label": "Life and health", "api_url": "https://www.edgepedia.org/api/v1/topics/life" }, { "id": "life.health", "label": "Human health and medicine", "api_url": "https://www.edgepedia.org/api/v1/topics/life.health" }, { "id": "life.health.clinical", "label": "Clinical assessment and procedures", "api_url": "https://www.edgepedia.org/api/v1/topics/life.health.clinical" }, { "id": "life.health.clinical.clinical-surgery", "label": "Surgery and surgical specialties", "api_url": "https://www.edgepedia.org/api/v1/topics/life.health.clinical.clinical-surgery" }, { "id": "life.health.clinical.clinical-surgery.vascular-and-endovascular-surgery-procedures", "label": "Vascular and endovascular surgery procedures", "api_url": "https://www.edgepedia.org/api/v1/topics/life.health.clinical.clinical-surgery.vascular-and-endovascular-surgery-procedures" } ], "geo": [ { "id": "geo.nongeo.t1946.life.health.clinical.clinical-surgery", "label": "Non-geographic · 1946 to 2000: Surgery and surgical specialties", "api_url": "https://www.edgepedia.org/api/v1/geo/geo.nongeo.t1946.life.health.clinical.clinical-surgery", "path": [ { "id": "geo.nongeo", "label": "Non-geographic", "api_url": "https://www.edgepedia.org/api/v1/geo/geo.nongeo" }, { "id": "geo.nongeo.t1946", "label": "Non-geographic · 1946 to 2000", "api_url": "https://www.edgepedia.org/api/v1/geo/geo.nongeo.t1946" }, { "id": "geo.nongeo.t1946.life", "label": "Life and health", "api_url": "https://www.edgepedia.org/api/v1/geo/geo.nongeo.t1946.life" }, { "id": "geo.nongeo.t1946.life.health", "label": "Human health and medicine", "api_url": "https://www.edgepedia.org/api/v1/geo/geo.nongeo.t1946.life.health" }, { "id": "geo.nongeo.t1946.life.health.clinical", "label": "Clinical assessment and procedures", "api_url": "https://www.edgepedia.org/api/v1/geo/geo.nongeo.t1946.life.health.clinical" }, { "id": "geo.nongeo.t1946.life.health.clinical.clinical-surgery", "label": "Surgery and surgical specialties", "api_url": "https://www.edgepedia.org/api/v1/geo/geo.nongeo.t1946.life.health.clinical.clinical-surgery" } ] } ], "excerpt": "Balloon angioplasty, also called coronary balloon angioplasty, is a minimally invasive procedure that widens narrowed arteries by inflating a catheter-mounted balloon against plaque; first performed on a coronary artery by Andreas Grüntzig in 1977.", "snippet": "Balloon angioplasty, also called coronary balloon angioplasty, is a minimally invasive procedure that widens narrowed arteries by inflating a catheter-mounted balloon against plaque; first performed on a coronary artery by Andreas Grüntzig in 1977.", "node": "life.health.clinical.clinical-surgery.vascular-and-endovascular-surgery-procedures", "markdown": "# Balloon angioplasty\n\nBalloon angioplasty is a minimally invasive procedure in which a catheter-mounted balloon is inflated inside a narrowed artery to press atherosclerotic plaque against the vessel wall and restore luminal diameter.[1](https://www.ncbi.nlm.nih.gov/books/NBK499894/) Unlike stenting, plain balloon angioplasty leaves no permanent implant behind; drug-coated balloons extend this \"leave-nothing-behind\" approach by delivering an antiproliferative drug without a scaffold.[2](https://www.nature.com/articles/s44325-026-00132-7) Today nearly every percutaneous coronary intervention finishes with a stent, so the balloon works mostly as a predilation and lesion-preparation tool, with stand-alone use reserved for selected settings.[3](https://textbooks.pcronline.com/the-pcr-textbook/balloon-angioplasty-technology)\n\n| Key fact | Detail |\n|---|---|\n| Mechanism | Balloon inflation presses intraluminal plaque against the arterial wall and widens the lumen.[1](https://www.ncbi.nlm.nih.gov/books/NBK499894/) |\n| First coronary case | Andreas Grüntzig, September 16, 1977, Zurich; reported in a 1978 Lancet letter and a 1979 NEJM series of 50 patients.[4](https://www.sciencedirect.com/science/article/pii/S0735109799003587) • [5](https://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2803%2912470-1/fulltext) |\n| First-series results | Successful in 32 of 50 patients; mean stenosis fell from 84% to 34%, gradient from 58 to 19 mm Hg.[6](https://www.nejm.org/doi/full/10.1056/NEJM197907123010201) |\n| Restenosis, balloon vs stent | 42.1% vs 31.6% at six months in STRESS; procedural success 89.6% vs 96.1%.[7](https://pubmed.ncbi.nlm.nih.gov/8041414/) |\n| Drug-coated balloons | Used in 7.2% of all coronary interventions; in-stent restenosis is about 10% of PCI.[8](https://www.ahajournals.org/doi/10.1161/JAHA.124.036839) |\n| US regulatory status | The AGENT paclitaxel-coated balloon is the first and, to date, only DCB with FDA approval for coronary in-stent restenosis.[9](https://www.mdpi.com/2077-0383/13/20/6243) |\n\n## How it works\n\nInflation of a balloon-tipped catheter at the stenosed segment compresses the atherosclerotic plaque against the arterial wall and increases luminal diameter.[1](https://www.ncbi.nlm.nih.gov/books/NBK499894/) The dilation also creates a blunt dehiscence effect: the arterial media fractures and separates from the intima, and the media and adventitia are stretched.[10](https://clinicalpub.com/endovascular-therapeutic-technique/) Controlled dissection is part of the mechanism, not only a complication: intravascular ultrasound studies have demonstrated coronary dissection in 50–80% of balloon angioplasty procedures.[11](https://uea-test-2026.eprints-hosting.org/id/eprint/98764/1/Accepted_final_manuscript_Coronary_dissection.pdf) Histological work published in 1983 described the corresponding injuries: intimal tears, cracks, and fractures with variable medial penetration, and dissections propagating antegrade or retrograde.[11](https://uea-test-2026.eprints-hosting.org/id/eprint/98764/1/Accepted_final_manuscript_Coronary_dissection.pdf) Uncomplicated dissections do not by themselves raise restenosis risk; in one analysis, when the final transtenotic pressure gradient exceeded 15 mm Hg, restenosis was 35% with dissection versus 39% without (not significant).[11](https://uea-test-2026.eprints-hosting.org/id/eprint/98764/1/Accepted_final_manuscript_Coronary_dissection.pdf) The principal failure mode of balloon-only dilation is elastic recoil after deflation, which, together with restenosis, motivated the invention of bare metal stents.[1](https://www.ncbi.nlm.nih.gov/books/NBK499894/)\n\n## How it is done\n\nAccess is gained by percutaneous puncture of the femoral, radial, or brachial artery; the radial approach is preferred because it reduces discomfort, speeds ambulation, and lowers bleeding and pseudoaneurysm complications.[12](https://www.merckmanuals.com/professional/cardiovascular-disorders/coronary-artery-disease/percutaneous-coronary-interventions-pci) A guidewire crosses the lesion, and a balloon-tipped catheter guided by fluoroscopy or intravascular ultrasound is aligned within the stenosis and inflated.[12](https://www.merckmanuals.com/professional/cardiovascular-disorders/coronary-artery-disease/percutaneous-coronary-interventions-pci)\n\nBalloon choice follows lesion and vessel characteristics. Nominal pressure, where the balloon reaches its designed diameter and length, generally lies between 4 and 10 atm; rated burst pressure, below which fewer than 1% of tested balloons burst, typically ranges from 6 to 20 atm.[10](https://clinicalpub.com/endovascular-therapeutic-technique/) Semi-compliant balloons use soft materials such as PEBAX and show a non-uniform \"dog-bone\" dilation with lower burst pressures; non-compliant balloons made of nylon or PET grow minimally in diameter, tolerate higher pressure, and suit calcified lesions.[13](https://pmc.ncbi.nlm.nih.gov/articles/PMC10517552/) For drug-coated balloon work, predilation uses a semi-compliant or non-compliant balloon at a 1:1 balloon-to-reference-vessel ratio, and the DCB should extend at least 2 mm beyond the lesion on each side.[9](https://www.mdpi.com/2077-0383/13/20/6243)\n\nPredilation is judged adequate when residual stenosis is ≤30%, dissection is no worse than type B, and TIMI flow (0–3 scale grading blood flow in heart arteries) is grade 3; the DCB is then inflated to at least nominal pressure for a minimum of 30 seconds.[14](https://www.jacc.org/doi/10.1016/j.jcin.2024.04.014) If the result is unacceptable, bailout stenting follows.[14](https://www.jacc.org/doi/10.1016/j.jcin.2024.04.014)\n\n## Origin\n\nThe percutaneous treatment for peripheral artery disease dilated lower-extremity stenoses with progressively larger coaxial dilators; an accidental recanalization of an iliac artery during an aortogram preceded it.[15](https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2014.00015/full) • [10](https://clinicalpub.com/endovascular-therapeutic-technique/) At the University of Zürich, a balloon-tipped catheter was applied to a severely stenosed femoral artery, calling the procedure \"percutaneous transluminal dilatation\", and published the balloon catheter principle with the first 15 patients in a German-language journal, which delayed international recognition.[15](https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2014.00015/full)\n\nCoronary balloon angioplasty dilates a discrete left anterior descending stenosis in a 38-year-old man.[5](https://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2803%2912470-1/fulltext) Andreas Grüntzig reported the method in a 1978 letter in [The Lancet](https://www.edgepedia.org/the-lancet), describing transluminal dilatation of coronary-artery stenosis in the first five coronary patients.[16](https://doi.org/10.1016/s0140-6736%2878%2990500-7) A 50-patient series followed in the New England Journal of Medicine in 1979.[6](https://www.nejm.org/doi/full/10.1056/NEJM197907123010201) In the first NHLBI PTCA Registry (631 patients from September 1977 onward), dilation succeeded in 59% of stenosed arteries, mean stenosis fell from 83% to 31%, and emergency bypass was required in 6%.[4](https://www.sciencedirect.com/science/article/pii/S0735109799003587) Steerable guidewires (1982) and coronary stents followed, converting balloon angioplasty into today's stent-centered PCI.[4](https://www.sciencedirect.com/science/article/pii/S0735109799003587)\n\n## Variants\n\n**Plain old balloon angioplasty (POBA)** is uncoated balloon dilation alone, now mainly a predilation step or a bailout-grade therapy. **Cutting balloons** carry 3–4 longitudinally bonded microtomes that score plaque; the concept was described by Peter Barath, Michael C. Fishbein, Sandor Vari, and [James S. Forrester](https://www.edgepedia.org/james-s-forrester-cardiologist) in 1991 in The American Journal of Cardiology,[17](https://doi.org/10.1016/0002-9149%2891%2990207-2) with first clinical experience reported by C. Unterberg and colleagues in 1993 in Clinical Cardiology.[18](https://doi.org/10.1002/clc.4960160907) In a 1,238-patient randomized trial, six-month restenosis was 31.4% for the cutting balloon versus 30.4% for POBA, and all five coronary perforations occurred in the cutting-balloon arm.[19](https://orbi.uliege.be/bitstream/2268/168534/1/cutting%20balloon.pdf) **Scoring balloons** score the neointima before drug-coated balloon therapy; the ISAR-DESIRE 4 trial by Sebastian Kufner and colleagues (2017) tested scoring-balloon neointimal modification in DES restenosis.[20](https://doi.org/10.1016/j.jcin.2017.04.024) A pooled analysis of 2,128 in-stent-restenosis lesions found specialty-balloon predilation before DCB was associated with lower MACE than conventional balloons (8.0% vs 18.0%; adjusted HR 0.45).[21](https://recintervcardiol.org/images/pdf-files/RECIC-26-047-L-ENG-RECICEM26000594.pdf)\n\n**Drug-coated balloons** are semi-compliant balloons coated with an antirestenotic drug released on wall contact. The paclitaxel-coated Paccocath balloon was described by Bruno Scheller and colleagues in Circulation in 2004,[22](https://doi.org/10.1161/01.cir.0000138929.71660.e0) and recommendations by Franz Kleber, Detlef Mathey, Harald Rittger, and Bruno Scheller on DCB use followed in 2011 in EuroIntervention.[23](https://doi.org/10.4244/eijv7ska21) In the first-in-human PACCOCATH-ISR trial, DCB reduced late lumen loss (0.03 vs 0.74 mm), binary restenosis (5% vs 43%), and TLR (0% vs 23%) at six months versus uncoated balloons.[24](https://eurointervention.pcronline.com/article/the-current-status-of-drug-coated-balloon) [Paclitaxel](https://www.edgepedia.org/paclitaxel) and sirolimus are the only antiproliferative drugs in current DCBs; paclitaxel is highly lipophilic and transfers rapidly, while sirolimus's low lipophilicity limits vessel-wall penetration and retention.[25](https://www.asiaintervention.org/wp-content/uploads/2024/02/003_AIJ-D-23-00010_Lazar.pdf) • [26](https://link.springer.com/article/10.1007/s12928-026-01248-4)\n\n## Applications\n\nIn the coronary setting, ESC guidelines recommend DCBs solely for in-stent restenosis (Class 1A since 2014), though European operators use them off-guideline for small-vessel de novo lesions and diffuse disease.[26](https://link.springer.com/article/10.1007/s12928-026-01248-4) • [9](https://www.mdpi.com/2077-0383/13/20/6243) In small-vessel disease, the BASKET-SMALL 2 trial by Raban V Jeger and colleagues (2018) found DCBs non-inferior to DES.[27](https://doi.org/10.1016/s0140-6736%2818%2931719-7) Coronary bifurcation lesions account for 15–20% of PCI cases, where DCB treatment of the side branch is an alternative to POBA or stenting.[9](https://www.mdpi.com/2077-0383/13/20/6243) The AGENT IDE trial (2024) showed paclitaxel-coated balloons reduced one-year target-lesion failure versus uncoated balloons in coronary in-stent restenosis (17.9% vs 28.6%; HR 0.59),[28](https://jamanetwork.com/journals/jama/fullarticle/2816073) and the AGENT balloon subsequently became the first DCB with FDA approval for coronary ISR in the United States.[9](https://www.mdpi.com/2077-0383/13/20/6243) ULTIMATE III (2024) showed IVUS-guided DCB angioplasty reduced seven-month late lumen loss versus angiography guidance in de novo lesions among high-bleeding-risk patients.[14](https://www.jacc.org/doi/10.1016/j.jcin.2024.04.014)\n\nIn peripheral arteries, balloon angioplasty is a primary therapy. In Grüntzig's early Zürich series, initial success was 84% for femoropopliteal occlusions and 92% for iliac stenoses, with two-year patency of 72% and 87% respectively.[29](https://ajronline.org/doi/pdf/10.2214/ajr.132.4.547?download=true) In the LEVANT 2 trial of femoropopliteal disease, a paclitaxel DCB achieved primary patency of 65.2% versus 52.6% for standard PTA.[10](https://clinicalpub.com/endovascular-therapeutic-technique/)\n\n## Limitations and alternatives\n\nBalloon-only dilation fails by elastic recoil after deflation, flow-limiting dissection, acute closure, and restenosis. Acute thrombosis risk with balloon angioplasty alone is 1–2%, and catheter-induced coronary dissection occurs in <0.1% to about 2% of PCI; iatrogenic coronary perforation occurs in 0.1–0.8% of cases.[12](https://www.merckmanuals.com/professional/cardiovascular-disorders/coronary-artery-disease/percutaneous-coronary-interventions-pci) • [1](https://www.ncbi.nlm.nih.gov/books/NBK499894/) Published restenosis figures differ by source: the Merck Manual gives approximately 20–30% within months, while CAVEAT-I states 30 to 50 percent.[12](https://www.merckmanuals.com/professional/cardiovascular-disorders/coronary-artery-disease/percutaneous-coronary-interventions-pci) • [30](https://www.nejm.org/doi/full/10.1056/NEJM199307223290401)\n\nAgainst stenting, randomized trials consistently favor stents. In STRESS, reported by David L. Fischman and colleagues in 1994 in the New England Journal of Medicine, procedural success was 89.6% versus 96.1% and six-month restenosis 42.1% versus 31.6%.[7](https://pubmed.ncbi.nlm.nih.gov/8041414/) In Benestent II, reported by Patrick W Serruys and colleagues in 1998 in The Lancet, six-month restenosis was 31% after balloon angioplasty versus 16% after heparin-coated stenting.[31](https://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2897%2911128-X/abstract) Against atherectomy, CAVEAT-I found six-month restenosis of 57% for angioplasty versus 50% for directional atherectomy, but atherectomy caused more early complications and worse death or MI at six months (8.6% vs 4.6%).[30](https://www.nejm.org/doi/full/10.1056/NEJM199307223290401) A 2026 meta-analysis of atherectomy versus balloon preparation before DES in severely calcified lesions found no MACE difference, supporting a balloon-first strategy with atherectomy reserved for undilatable or uncrossable lesions.[32](https://sage.cnpereading.com/doi/10.1177/20480040261446478) [Stenting](https://www.edgepedia.org/stenting) rivals coronary artery bypass grafting for single- and double-vessel disease with less morbidity than open surgery.[1](https://www.ncbi.nlm.nih.gov/books/NBK499894/)\n\nAgainst drug-eluting stents, in-stent restenosis ran at 32–55% of PCI in the pre-stent era, 17–41% with bare metal stents, and below 10% with second-generation drug-eluting stents and drug-eluting balloons.[1](https://www.ncbi.nlm.nih.gov/books/NBK499894/) The REC-CAGEFREE I trial tested DCB angioplasty with rescue stenting against intended stenting for de novo lesions,[33](https://www.jacc.org/doi/10.1016/j.jacc.2025.07.049) and a 2025 pooled analysis of 4,621 all-comers found the DCB-only strategy carried higher risk of device-oriented endpoints and revascularization than DES at three years, in line with that trial. A 2026 meta-analysis of 23 RCTs (8,123 patients) likewise found higher TLR with DCB versus DES overall (OR 2.22, 95% CI 1.49–3.33), with the small-vessel subgroup the main exception.[34](https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2026.1843262/full) Balloon-only therapy stands on firmest ground in in-stent restenosis, small vessels, and bleeding-risk-sensitive patients, and remains adjunctive elsewhere.\n\n## References\n\n1. [Angioplasty - StatPearls (NCBI Bookshelf)](https://www.ncbi.nlm.nih.gov/books/NBK499894/)\n2. [Drug-coated balloon angioplasty in coronary artery disease: state of the art review (npj Cardiovascular Health, 2026)](https://www.nature.com/articles/s44325-026-00132-7)\n3. [Balloon angioplasty technology – The PCR Textbook](https://textbooks.pcronline.com/the-pcr-textbook/balloon-angioplasty-technology)\n4. [50th Anniversary Historical Article: Percutaneous transluminal coronary angioplasty (NHLBI PTCA Registry)](https://www.sciencedirect.com/science/article/pii/S0735109799003587)\n5. [fulltext (thelancet.com)](https://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2803%2912470-1/fulltext)\n6. [Nonoperative Dilatation of Coronary-Artery Stenosis, Percutaneous Transluminal Coronary Angioplasty](https://www.nejm.org/doi/full/10.1056/NEJM197907123010201)\n7. [A randomized comparison of coronary-stent placement and balloon angioplasty (Stress Restenosis Study), N Engl J Med 1994](https://pubmed.ncbi.nlm.nih.gov/8041414/)\n8. [Drug-Coated Balloons Versus Drug-Eluting Stents or Plain Old Balloon Angioplasty: A Long-Term In-Stent Restenosis Study (JAHA 2024, SCAAR registry)](https://www.ahajournals.org/doi/10.1161/JAHA.124.036839)\n9. [Contemporary Use of Drug-Coated Balloons for Coronary Angioplasty: A Comprehensive Review (J Clin Med, 2024)](https://www.mdpi.com/2077-0383/13/20/6243)\n10. [Endovascular Therapeutic Technique - Balloon Angioplasty chapter](https://clinicalpub.com/endovascular-therapeutic-technique/)\n11. [Coronary dissection as a mechanism of balloon angioplasty (accepted manuscript)](https://uea-test-2026.eprints-hosting.org/id/eprint/98764/1/Accepted_final_manuscript_Coronary_dissection.pdf)\n12. [Percutaneous Coronary Interventions (PCI) - Merck Manual Professional Edition](https://www.merckmanuals.com/professional/cardiovascular-disorders/coronary-artery-disease/percutaneous-coronary-interventions-pci)\n13. [Design of percutaneous transluminal coronary angioplasty balloon catheters](https://pmc.ncbi.nlm.nih.gov/articles/PMC10517552/)\n14. [Intravascular Ultrasound vs Angiography-Guided Drug-Coated Balloon Angioplasty: The ULTIMATE III Trial](https://www.jacc.org/doi/10.1016/j.jcin.2024.04.014)\n15. [Balloon Angioplasty – The Legacy of Andreas Grüntzig, M.D. (1939–1985)](https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2014.00015/full)\n16. [TRANSLUMINAL DILATATION OF CORONARY-ARTERY STENOSIS (The Lancet, 1978)](https://doi.org/10.1016/s0140-6736%2878%2990500-7)\n17. [Cutting balloon: A novel approach to percutaneous angioplasty (The American Journal of Cardiology, 1991)](https://doi.org/10.1016/0002-9149%2891%2990207-2)\n18. [C. Unterberg and colleagues (1993). Cutting balloon coronary angioplasty, initial clinical experience. Clinical Cardiology.](https://doi.org/10.1002/clc.4960160907)\n19. [Cutting balloon angioplasty for the prevention of restenosis: results of the Cutting Balloon Global Randomized Trial (Am J Cardiol 2002;90:1079–1083)](https://orbi.uliege.be/bitstream/2268/168534/1/cutting%20balloon.pdf)\n20. [Sebastian Kufner and colleagues (2017). Neointimal Modification With Scoring Balloon and Efficacy of Drug-Coated Balloon Therapy in Patients With Restenosis in Drug-Eluting Coronary Stents. JACC: Cardiovascular Interventions.](https://doi.org/10.1016/j.jcin.2017.04.024)\n21. [Lesion preparation before drug-coated balloon angioplasty for in-stent restenosis: comparison between specialty and conventional balloons (REC: Interventional Cardiology, 2026)](https://recintervcardiol.org/images/pdf-files/RECIC-26-047-L-ENG-RECICEM26000594.pdf)\n22. [Bruno Scheller and colleagues (2004). Paclitaxel Balloon Coating, a Novel Method for Prevention and Therapy of Restenosis. Circulation.](https://doi.org/10.1161/01.cir.0000138929.71660.e0)\n23. [Franz Kleber and colleagues (2011). How to use the drug-eluting balloon: recommendations by the German consensus group. EuroIntervention.](https://doi.org/10.4244/eijv7ska21)\n24. [The current status of drug-coated balloons in percutaneous coronary and peripheral interventions (EuroIntervention)](https://eurointervention.pcronline.com/article/the-current-status-of-drug-coated-balloon)\n25. [A 2024 scientific update on the clinical performance of drug-coated balloons (AsiaIntervention)](https://www.asiaintervention.org/wp-content/uploads/2024/02/003_AIJ-D-23-00010_Lazar.pdf)\n26. [Drug-coated balloons in coronary in-stent restenosis: systematic review and meta-analysis comparing sirolimus and biolimus with paclitaxel platforms (2026)](https://link.springer.com/article/10.1007/s12928-026-01248-4)\n27. [Drug-coated balloons for small coronary artery disease (BASKET-SMALL 2): an open-label randomised non-inferiority trial (The Lancet, 2018)](https://doi.org/10.1016/s0140-6736%2818%2931719-7)\n28. [Paclitaxel-Coated Balloon vs Uncoated Balloon for Coronary In-Stent Restenosis: The AGENT IDE Randomized Clinical Trial (JAMA 2024)](https://jamanetwork.com/journals/jama/fullarticle/2816073)\n29. [Technique of percutaneous transluminal angioplasty with the Gruntzig balloon catheter (AJR, 1979)](https://ajronline.org/doi/pdf/10.2214/ajr.132.4.547?download=true)\n30. [A Comparison of Directional Atherectomy with Coronary Angioplasty (CAVEAT-I)](https://www.nejm.org/doi/full/10.1056/NEJM199307223290401)\n31. [abstract (thelancet.com)](https://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2897%2911128-X/abstract)\n32. [Coronary atherectomy versus balloon angioplasty before DES implantation in severely calcified lesions: systematic review and meta-analysis (2026)](https://sage.cnpereading.com/doi/10.1177/20480040261446478)\n33. [Indications for Use of Drug-Coated Balloons in Coronary Intervention: Academic Research Consortium Position Statement (JACC 2025)](https://www.jacc.org/doi/10.1016/j.jacc.2025.07.049)\n34. [Drug-coated balloons vs. drug-eluting stents for coronary artery disease: an updated systematic review and meta-analysis of randomized controlled trials (Frontiers, 2026)](https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2026.1843262/full)\n\n---\n*Topic: Encyclopedia › Life and health › Human health and medicine › Clinical assessment and procedures › Surgery and surgical specialties › Vascular and endovascular surgery procedures*\n\n*Initially written Sep 29, 2026 · Edited: Oct 15, 2026*\n\n*Copyright 2026 EdgeChat AI, a subsidiary of Biostate AI.*\n\nLicense: Edgepedia Community License 1.0, https://www.edgepedia.org/edgepedia/license\n", "same_as": [], "url": "https://www.edgepedia.org/balloon-angioplasty", "markdown_url": "https://www.edgepedia.org/balloon-angioplasty.md", "license": { "name": "Edgepedia Community License 1.0", "url": "https://www.edgepedia.org/edgepedia/license", "summary": "Free with credit, commercial use included. AI training is open to everyone. For other uses, organizations over USD 100M in revenue or 100M monthly users license separately.", "spdx": "LicenseRef-Edgepedia-Community-1.0" }, "credit": "\"Balloon angioplasty\", Edgepedia (EdgeChat), https://www.edgepedia.org/balloon-angioplasty. Edgepedia Community License 1.0.", "credit_md": "\"[Balloon angioplasty](https://www.edgepedia.org/balloon-angioplasty)\", Edgepedia (EdgeChat), [https://www.edgepedia.org/balloon-angioplasty](https://www.edgepedia.org/balloon-angioplasty). [Edgepedia Community License 1.0](https://www.edgepedia.org/edgepedia/license).", "credit_html": "\"Balloon angioplasty\", Edgepedia (EdgeChat), https://www.edgepedia.org/balloon-angioplasty. Edgepedia Community License 1.0.", "speakable": "Balloon angioplasty, also called coronary balloon angioplasty, is a minimally invasive procedure that widens narrowed arteries by inflating a catheter-mounted balloon against plaque; first performed on a coronary artery by Andreas Grüntzig in 1977." }