{ "id": "ep2vf7nfnt", "slug": "paclitaxel-chemotherapy", "title": "Paclitaxel chemotherapy", "updated": "2026-10-21", "topic_path": [ { "id": "life", "label": "Life and health", "api_url": "https://www.edgepedia.org/api/v1/topics/life" }, { "id": "life.health", "label": "Human health and medicine", "api_url": "https://www.edgepedia.org/api/v1/topics/life.health" }, { "id": "life.health.medicines", "label": "Medicines and therapeutics", "api_url": "https://www.edgepedia.org/api/v1/topics/life.health.medicines" }, { "id": "life.health.medicines.cancer-chemotherapy", "label": "Cancer chemotherapy and regimens", "api_url": "https://www.edgepedia.org/api/v1/topics/life.health.medicines.cancer-chemotherapy" }, { "id": "life.health.medicines.cancer-chemotherapy.taxane-and-anthracycline-regimens", "label": "Taxane and anthracycline regimens", "api_url": "https://www.edgepedia.org/api/v1/topics/life.health.medicines.cancer-chemotherapy.taxane-and-anthracycline-regimens" } ], "geo": [ { "id": "geo.nongeo.t1946.life.health.medicines.cancer-chemotherapy", "label": "Non-geographic · 1946 to 2000: Cancer chemotherapy and regimens", "api_url": "https://www.edgepedia.org/api/v1/geo/geo.nongeo.t1946.life.health.medicines.cancer-chemotherapy", "path": [ { "id": "geo.nongeo", "label": "Non-geographic", "api_url": "https://www.edgepedia.org/api/v1/geo/geo.nongeo" }, { "id": "geo.nongeo.t1946", "label": "Non-geographic · 1946 to 2000", "api_url": "https://www.edgepedia.org/api/v1/geo/geo.nongeo.t1946" }, { "id": "geo.nongeo.t1946.life", "label": "Life and health", "api_url": "https://www.edgepedia.org/api/v1/geo/geo.nongeo.t1946.life" }, { "id": "geo.nongeo.t1946.life.health", "label": "Human health and medicine", "api_url": "https://www.edgepedia.org/api/v1/geo/geo.nongeo.t1946.life.health" }, { "id": "geo.nongeo.t1946.life.health.medicines", "label": "Medicines and therapeutics", "api_url": "https://www.edgepedia.org/api/v1/geo/geo.nongeo.t1946.life.health.medicines" }, { "id": "geo.nongeo.t1946.life.health.medicines.cancer-chemotherapy", "label": "Cancer chemotherapy and regimens", "api_url": "https://www.edgepedia.org/api/v1/geo/geo.nongeo.t1946.life.health.medicines.cancer-chemotherapy" } ] } ], "excerpt": "Paclitaxel chemotherapy is cancer treatment with paclitaxel, a taxane drug originally isolated from the Pacific yew tree, FDA-approved in 1992 and used mainly for ovarian, breast, and lung cancers.", "snippet": "Paclitaxel chemotherapy is cancer treatment with paclitaxel, a taxane drug originally isolated from the Pacific yew tree, FDA-approved in 1992 and used mainly for ovarian, breast, and lung cancers.", "node": "life.health.medicines.cancer-chemotherapy.taxane-and-anthracycline-regimens", "markdown": "# Paclitaxel chemotherapy\n\nPaclitaxel chemotherapy is cancer treatment with paclitaxel, a taxane antimicrotubule cytotoxic drug given by intravenous infusion, used mainly for ovarian, breast, and lung cancers, and AIDS-related Kaposi's sarcoma.[1](https://www.ncbi.nlm.nih.gov/books/NBK536917/) • [2](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6d04b514-c85c-4db1-919e-21dd98172791) Originally isolated from the Pacific yew tree, *Taxus brevifolia*, and initially named taxol, the drug received accelerated FDA approval in 1992 for refractory ovarian cancer, with indications later extending to breast cancer, non-small-cell lung cancer (NSCLC), and Kaposi sarcoma.[1](https://www.ncbi.nlm.nih.gov/books/NBK536917/)\n\n| Key fact | Detail |\n| --- | --- |\n| Mechanism | Binds β-tubulin, stabilizes microtubules against depolymerization, and arrests cells at the G2/M phase[1](https://www.ncbi.nlm.nih.gov/books/NBK536917/) • [2](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6d04b514-c85c-4db1-919e-21dd98172791) |\n| Approved indications (paclitaxel injection) | Advanced ovarian carcinoma; breast cancer after failure or relapse; first-line NSCLC with cisplatin; second-line AIDS-related Kaposi's sarcoma[2](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6d04b514-c85c-4db1-919e-21dd98172791) |\n| Aqueous solubility | 0.7–2 μg/mL, requiring a 1:1 Cremophor EL/ethanol vehicle[3](https://link.springer.com/article/10.1007/s12272-026-01609-w) |\n| Premedication (solvent-based) | Dexamethasone 20 mg orally 12 and 6 hours before; diphenhydramine 50 mg IV and cimetidine 300 mg or ranitidine 50 mg IV 30–60 minutes before[4](https://www.pfizermedical.com/paclitaxel) |\n| nab-paclitaxel US approvals | January 7, 2005 (metastatic breast cancer); October 11, 2012 (NSCLC with carboplatin); September 6, 2013 (pancreatic cancer with gemcitabine)[5](https://www.fda.gov/media/133815/download?attachment=) |\n| nab vs solvent-based paclitaxel (metastatic breast, phase III) | Response 33% vs 19%; grade 4 neutropenia 9% vs 22%; grade 3 sensory neuropathy 10% vs 2%[6](https://doi.org/10.1200/jco.2005.04.937) |\n| Severe hypersensitivity (solvent-based) | 2–4% of patients in trials, with fatal reactions despite premedication[2](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6d04b514-c85c-4db1-919e-21dd98172791) |\n\n## How it works\n\nPaclitaxel binds the inner surface of microtubules near the nucleotide-binding site on β-tubulin, promotes microtubule assembly from tubulin dimers, and prevents depolymerization, inducing abnormal microtubule bundles and multiple asters during mitosis.[1](https://www.ncbi.nlm.nih.gov/books/NBK536917/) • [2](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6d04b514-c85c-4db1-919e-21dd98172791) Stabilization activates the spindle assembly checkpoint and arrests the cell cycle at the G2/M phase.[1](https://www.ncbi.nlm.nih.gov/books/NBK536917/) The compound has the formula \\(C\\_{47}H\\_{51}NO\\_{14}\\) and a molecular weight of 853.9 g/mol; docetaxel binds β-tubulin with greater affinity and is roughly twice as potent.[7](https://link.springer.com/article/10.1186/s12935-024-03415-0)\n\nClinical use is shaped by the drug's chemistry. Aqueous solubility is only 0.7–2 μg/mL, so the injectable formulation uses a 1:1 Cremophor EL (polyoxyl 35 castor oil) and ethanol vehicle.[3](https://link.springer.com/article/10.1007/s12272-026-01609-w) • [2](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6d04b514-c85c-4db1-919e-21dd98172791) Cremophor EL is eliminated slowly, with a terminal half-life of approximately 84 hours, and activates the complement cascade, the primary mechanism of vehicle-related hypersensitivity.[3](https://link.springer.com/article/10.1007/s12272-026-01609-w) Only 1–2% or less of circulating paclitaxel is unbound and pharmacologically active with this vehicle, contributing to nonlinear pharmacokinetics: a 30% dose increase from 135 to 175 mg/m² raised \\( C_{\\mathrm{max}} \\) by 75% and AUC by 81%.[3](https://link.springer.com/article/10.1007/s12272-026-01609-w) • [8](https://www.medicines.org.uk/emc/medicine/15842/spc) [Metabolism](https://www.edgepedia.org/metabolism) is primarily hepatic: CYP2C8 converts paclitaxel mainly to 6α-hydroxypaclitaxel, with two minor metabolites from CYP3A4.[2](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6d04b514-c85c-4db1-919e-21dd98172791)\n\n## How it is done\n\nLabel-recommended regimens for paclitaxel injection are: ovarian cancer, 135 or 175 mg/m² over 3 hours every 3 weeks; adjuvant node-positive breast cancer, 175 mg/m² over 3 hours every 3 weeks for 4 courses; NSCLC, 135 mg/m² over 24 hours followed by cisplatin 75 mg/m²; and AIDS-related Kaposi's sarcoma, 135 mg/m² every 3 weeks or 100 mg/m² every 2 weeks (dose intensity 45–50 mg/m²/week).[4](https://www.pfizermedical.com/paclitaxel) Infusion durations range from 3 to 24 hours, and administration uses a 0.22-µm in-line filter with a non-PVC, polyethylene-lined set.[1](https://www.ncbi.nlm.nih.gov/books/NBK536917/)\n\nBecause the Cremophor EL vehicle activates complement and causes hypersensitivity, all patients receive premedication: dexamethasone 20 mg orally approximately 12 and 6 hours before paclitaxel, diphenhydramine 50 mg IV 30–60 minutes before, and cimetidine 300 mg or ranitidine 50 mg IV 30–60 minutes before.[4](https://www.pfizermedical.com/paclitaxel) • [3](https://link.springer.com/article/10.1007/s12272-026-01609-w) For patients with advanced HIV, the dexamethasone dose is reduced to 10 mg.[1](https://www.ncbi.nlm.nih.gov/books/NBK536917/) [Bone marrow](https://www.edgepedia.org/bone-marrow) suppression, primarily neutropenia, is the dose-limiting toxicity, with neutrophil nadirs at a median of 11 days; treatment requires baseline neutrophils of at least 1500 cells/mm³ (1000 cells/mm³ for [Kaposi's sarcoma](https://www.edgepedia.org/kaposis-sarcoma)).[2](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6d04b514-c85c-4db1-919e-21dd98172791)\n\n## Origin\n\nSamples from a single Pacific yew tree were collected by USDA botanist Arthur Barclay in 1962 during an NCI–USDA screening program that tested 115,000 extracts from 15,000 plant species between 1960 and 1981.[9](https://pmc.ncbi.nlm.nih.gov/articles/PMC4161504/) Working under NCI contract at the Research Triangle Institute, colleagues received the samples and had isolated and named taxol; the structure was published in 1971 in the [Journal of the American Chemical Society](https://www.edgepedia.org/journal-of-the-american-chemical-society).[9](https://pmc.ncbi.nlm.nih.gov/articles/PMC4161504/) • [10](https://doi.org/10.1021/ja00738a045) In 1979, Schiff, Fant, and Horwitz of the [Albert Einstein College of Medicine](https://www.edgepedia.org/albert-einstein-college-of-medicine) reported in Nature that taxol promotes microtubule assembly in vitro, establishing its mechanism.[11](https://doi.org/10.1038/277665a0) • [12](https://www.cancer.gov/research/progress/discovery/taxol)\n\nClinical development moved through phase I trials in 1984 and phase II in 1985; a 1989 phase II trial found that 30% of patients with advanced ovarian cancer responded.[9](https://pmc.ncbi.nlm.nih.gov/articles/PMC4161504/) • [12](https://www.cancer.gov/research/progress/discovery/taxol) In 1991 the NCI selected Bristol-Myers Squibb to commercialize the drug; the FDA approved it for ovarian cancer in 1992, followed by breast cancer in 1994.[9](https://pmc.ncbi.nlm.nih.gov/articles/PMC4161504/) • [12](https://www.cancer.gov/research/progress/discovery/taxol) Supply was a constraint: in 1988, manufacturing taxol from yew bark was estimated to cost 10 times the NCI project budget, and bark harvesting killed the trees, prompting the 1992 Pacific Yew Act.[9](https://pmc.ncbi.nlm.nih.gov/articles/PMC4161504/) Semisynthesis from 10-deacetylbaccatin III obtained from yew needles became the standard production route and today accounts for roughly 80% of the market; BMS stopped bark extraction at the end of 1994.[13](https://www.mdpi.com/1420-3049/28/22/7517) [Total synthesis](https://www.edgepedia.org/total-synthesis) was reported in 1994 by Robert A. Holton and colleagues in a route requiring roughly 40 reaction steps.[14](https://doi.org/10.1021/ja00083a066) • [9](https://pmc.ncbi.nlm.nih.gov/articles/PMC4161504/)\n\n## Variants\n\nThe main variant is nab-paclitaxel (paclitaxel protein-bound particles, Abraxane), paclitaxel formulated as albumin-bound nanoparticles with a mean particle size of approximately 130 nm, in which the drug is in a non-crystalline, amorphous state.[15](https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=15ca4829-8fee-45f9-b4bc-b31c15732cd6) A phase III trial reported by William J. Gradishar and colleagues in 2005 compared ABI-007 (nab-paclitaxel) 260 mg/m² without premedication against solvent-based paclitaxel 175 mg/m² with premedication in 454 patients with metastatic breast cancer.[6](https://doi.org/10.1200/jco.2005.04.937) nab-[Paclitaxel](https://www.edgepedia.org/paclitaxel) was approved in the US on January 7, 2005 for metastatic breast cancer, on October 11, 2012 for first-line locally advanced or metastatic NSCLC with carboplatin, and on September 6, 2013 for first-line metastatic pancreatic adenocarcinoma with gemcitabine.[5](https://www.fda.gov/media/133815/download?attachment=) Its infusions run 30 minutes instead of 3 hours and premedication is eliminated.[3](https://link.springer.com/article/10.1007/s12272-026-01609-w) Recommended dosages are 260 mg/m² every 3 weeks for breast cancer, 100 mg/m² on days 1, 8, and 15 of each 21-day cycle for NSCLC, and 125 mg/m² on days 1, 8, and 15 of each 28-day cycle for pancreatic cancer.[16](https://www.accessdata.fda.gov/Drugsatfda_docs/Label/2020/021660s047lbl.Pdf) nab-Paclitaxel is thought to act partly through Gp60 albumin receptors on endothelial cells, increasing transcytosis and tumor drug concentration.[17](https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1157306/full)\n\nOther Cremophor-free platforms exist: the EMA authorized Apealea, a water-soluble micellar paclitaxel, on November 20, 2018, for first relapse of platinum-sensitive ovarian, peritoneal, or fallopian tube cancer with carboplatin, and Genexol-PM is also approved; these formulations remove the need for steroid premedication, but severe myelosuppression remains an intrinsic dose-limiting toxicity of paclitaxel.[3](https://link.springer.com/article/10.1007/s12272-026-01609-w) Related taxanes include docetaxel, marketed in 1996, and cabazitaxel, FDA-approved in 2010 for advanced prostate cancer.[13](https://www.mdpi.com/1420-3049/28/22/7517) A 2026 review of formulation strategies concludes that solvent-free albumin-bound paclitaxel mitigates Cremophor EL-related toxicity and nonlinear pharmacokinetics, that liposomal and micellar formulations have shown inconsistent clinical translation, and that actively targeted platforms remain largely preclinical.[3](https://link.springer.com/article/10.1007/s12272-026-01609-w)\n\n## Applications\n\nIn ovarian cancer, the pivotal first-line evidence is an EORTC-led Intergroup trial in which 680 patients received paclitaxel 175 mg/m² over 3 hours plus cisplatin 75 mg/m² or cyclophosphamide/cisplatin; the paclitaxel arm had a significantly higher response rate and longer time to progression and survival.[2](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6d04b514-c85c-4db1-919e-21dd98172791) In the GOG-111 trial, paclitaxel/cisplatin improved overall response rate (73% vs 60%) and overall survival (38 vs 24 months) over cisplatin/cyclophosphamide in advanced ovarian cancer.[3](https://link.springer.com/article/10.1007/s12272-026-01609-w)\n\nIn breast cancer, doxorubicin 50 mg/m² followed 24 hours later by paclitaxel 220 mg/m² gave response rates of 68% vs 55% against FAC, time to progression 8.2 vs 6.2 months, and median survival 23.0 vs 18.3 months.[8](https://www.medicines.org.uk/emc/medicine/15842/spc) In 188 patients with HER2-overexpressing disease, adding trastuzumab to paclitaxel 175 mg/m² improved time to progression (6.9 vs 3.0 months), response rate (41% vs 17%), and duration of response (10.5 vs 4.5 months).[8](https://www.medicines.org.uk/emc/medicine/15842/spc) In pancreatic cancer, nab-paclitaxel plus gemcitabine improved overall survival (8.5 vs 6.7 months) and response rate (23% vs 7%) over gemcitabine alone, and the FDA approved the combination in 2013 based on the MPACT trial.[3](https://link.springer.com/article/10.1007/s12272-026-01609-w) • [12](https://www.cancer.gov/research/progress/discovery/taxol)\n\n## Limitations and alternatives\n\nHypersensitivity is the signature risk of solvent-based paclitaxel: anaphylaxis and severe reactions occurred in 2 to 4% of patients in trials, with fatal reactions despite premedication.[2](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6d04b514-c85c-4db1-919e-21dd98172791) Severe neutropenia (below 500 cells/mm³) occurred in 27% of patients treated at 175 mg/m², lasting 7 days or more in only 1%.[18](https://sandoz-ca.cms.sandoz.com/sites/default/files/Media%20Documents/Paclitaxel%20Injection%20PMe%202021-10-18.pdf) [Peripheral neuropathy](https://www.edgepedia.org/peripheral-neuropathy) affected 60% of all patients (3% severe), increasing with cumulative dose.[18](https://sandoz-ca.cms.sandoz.com/sites/default/files/Media%20Documents/Paclitaxel%20Injection%20PMe%202021-10-18.pdf) Paclitaxel carries boxed warnings for hypersensitivity and bone marrow suppression.[1](https://www.ncbi.nlm.nih.gov/books/NBK536917/)\n\nResistance limits sequential taxane use. Mechanisms include efflux pump activation (MDR1/[P-glycoprotein](https://www.edgepedia.org/p-glycoprotein), ABCB1, MRP1), altered apoptosis regulation, TRAG-3/CSAG2 upregulation, and the βIII-tubulin isoform, which has low affinity for paclitaxel.[7](https://link.springer.com/article/10.1186/s12935-024-03415-0) • [17](https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1157306/full) Cross-resistance is substantial: among 484 metastatic gastric cancer patients who received both taxanes sequentially, the second taxane achieved a 5% response rate and 17.9% disease control rate, while docetaxel showed 25% activity in paclitaxel-pretreated breast cancer.[7](https://link.springer.com/article/10.1186/s12935-024-03415-0) Against docetaxel directly, a Cochrane review of seven RCTs (1,694 participants) in metastatic breast cancer found no statistically significant difference in overall survival, progression-free survival, or response rate; grade 3–4 hematologic toxicity, mucositis, diarrhea, and fatigue were more common with docetaxel, and in first-line trials paclitaxel-based regimens improved overall survival (HR 0.73, 95% CI 0.56 to 0.94).[19](https://www.ncbi.nlm.nih.gov/books/NBK126894/)\n\nFor nab-paclitaxel versus solvent-based paclitaxel, the 2005 phase III trial found a higher response rate (33% vs 19%; P=.001), longer time to progression (23.0 vs 16.9 weeks; HR 0.75), lower grade 4 neutropenia (9% vs 22%) despite a 49% higher paclitaxel dose, more grade 3 sensory neuropathy (10% vs 2%) that improved with a median of 22 days, and no hypersensitivity despite no premedication and 30-minute administration.[6](https://doi.org/10.1200/jco.2005.04.937) The FDA label, using a reconciled target-lesion endpoint for the same trial, reports 21.5% vs 11.1% response and no statistically significant overall survival difference, so the size of the efficacy advantage depends on the endpoint chosen.[15](https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=15ca4829-8fee-45f9-b4bc-b31c15732cd6)\n\n## References\n\n1. [Paclitaxel, StatPearls (NCBI Bookshelf)](https://www.ncbi.nlm.nih.gov/books/NBK536917/)\n2. [DailyMed - PACLITAXEL injection (FDA label)](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6d04b514-c85c-4db1-919e-21dd98172791)\n3. [Recent paclitaxel formulation strategies: expanding the therapeutic index (Archives of Pharmacal Research, 2026)](https://link.springer.com/article/10.1007/s12272-026-01609-w)\n4. [Paclitaxel Injection, USP, Pfizer Medical (US prescribing information)](https://www.pfizermedical.com/paclitaxel)\n5. [FDA Multi-discipline Review: Abraxane (nab-paclitaxel) pediatric indication](https://www.fda.gov/media/133815/download?attachment=)\n6. [William J. Gradishar and colleagues (2005). Phase III Trial of Nanoparticle Albumin-Bound Paclitaxel Compared With Polyethylated Castor Oil–Based Paclitaxel in Women With Breast Cancer. Journal of Clinical Oncology.](https://doi.org/10.1200/jco.2005.04.937)\n7. [Key genes and molecular mechanisms related to Paclitaxel Resistance (Cancer Cell International, 2024)](https://link.springer.com/article/10.1186/s12935-024-03415-0)\n8. [Paclitaxel 6 mg/ml concentrate SmPC (emc)](https://www.medicines.org.uk/emc/medicine/15842/spc)\n9. [How Taxol/paclitaxel kills cancer cells](https://pmc.ncbi.nlm.nih.gov/articles/PMC4161504/)\n10. [Mansukhlal C. Wani and colleagues (1971). Plant antitumor agents. VI. Isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. Journal of the American Chemical Society.](https://doi.org/10.1021/ja00738a045)\n11. [PETER B. SCHIFF, JANE FANT, SUSAN B. HORWITZ (1979). Promotion of microtubule assembly in vitro by taxol. Nature.](https://doi.org/10.1038/277665a0)\n12. [Discovery of Taxol (NCI)](https://www.cancer.gov/research/progress/discovery/taxol)\n13. [Research Advances in Clinical Applications, Anticancer Mechanism, Total Chemical Synthesis, Semi-Synthesis and Biosynthesis of Paclitaxel (Molecules, 2023)](https://www.mdpi.com/1420-3049/28/22/7517)\n14. [Robert A. Holton and colleagues (1994). First total synthesis of taxol. 1. Functionalization of the B ring. Journal of the American Chemical Society.](https://doi.org/10.1021/ja00083a066)\n15. [DailyMed - PACLITAXEL protein-bound particles (albumin-bound) label](https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=15ca4829-8fee-45f9-b4bc-b31c15732cd6)\n16. [ABRAXANE (paclitaxel protein-bound particles) FDA label, 2020](https://www.accessdata.fda.gov/Drugsatfda_docs/Label/2020/021660s047lbl.Pdf)\n17. [Chemotherapeutic properties and side-effects associated with the clinical practice of terpene alkaloids: paclitaxel, docetaxel, and cabazitaxel (Frontiers in Pharmacology, 2023)](https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1157306/full)\n18. [Paclitaxel Injection USP, Sandoz Canada Product Monograph (2021)](https://sandoz-ca.cms.sandoz.com/sites/default/files/Media%20Documents/Paclitaxel%20Injection%20PMe%202021-10-18.pdf)\n19. [Paclitaxel-based versus docetaxel-based regimens in metastatic breast cancer: systematic review and meta-analysis of RCTs (Cochrane)](https://www.ncbi.nlm.nih.gov/books/NBK126894/)\n\n---\n*Topic: Encyclopedia › Life and health › Human health and medicine › Medicines and therapeutics › Cancer chemotherapy and regimens › Taxane and anthracycline regimens*\n\n*Initially written Sep 29, 2026 · Edited: Oct 15, 2026; Oct 21, 2026*\n\n*Copyright 2026 EdgeChat AI, a subsidiary of Biostate AI.*\n\nLicense: Edgepedia Community License 1.0, https://www.edgepedia.org/edgepedia/license\n", "same_as": [], "url": "https://www.edgepedia.org/paclitaxel-chemotherapy", "markdown_url": "https://www.edgepedia.org/paclitaxel-chemotherapy.md", "license": { "name": "Edgepedia Community License 1.0", "url": "https://www.edgepedia.org/edgepedia/license", "summary": "Free with credit, commercial use included. AI training is open to everyone. For other uses, organizations over USD 100M in revenue or 100M monthly users license separately.", "spdx": "LicenseRef-Edgepedia-Community-1.0" }, "credit": "\"Paclitaxel chemotherapy\", Edgepedia (EdgeChat), https://www.edgepedia.org/paclitaxel-chemotherapy. Edgepedia Community License 1.0.", "credit_md": "\"[Paclitaxel chemotherapy](https://www.edgepedia.org/paclitaxel-chemotherapy)\", Edgepedia (EdgeChat), [https://www.edgepedia.org/paclitaxel-chemotherapy](https://www.edgepedia.org/paclitaxel-chemotherapy). [Edgepedia Community License 1.0](https://www.edgepedia.org/edgepedia/license).", "credit_html": "\"Paclitaxel chemotherapy\", Edgepedia (EdgeChat), https://www.edgepedia.org/paclitaxel-chemotherapy. Edgepedia Community License 1.0.", "speakable": "Paclitaxel chemotherapy is cancer treatment with paclitaxel, a taxane drug originally isolated from the Pacific yew tree, FDA-approved in 1992 and used mainly for ovarian, breast, and lung cancers." }