{ "id": "epsxskkx0k", "slug": "per-oral-endoscopic-myotomy", "title": "Per-oral endoscopic myotomy", "updated": "2026-10-15", "topic_path": [ { "id": "life", "label": "Life and health", "api_url": "https://www.edgepedia.org/api/v1/topics/life" }, { "id": "life.health", "label": "Human health and medicine", "api_url": "https://www.edgepedia.org/api/v1/topics/life.health" }, { "id": "life.health.clinical", "label": "Clinical assessment and procedures", "api_url": "https://www.edgepedia.org/api/v1/topics/life.health.clinical" }, { "id": "life.health.clinical.clinical-endoscopy-biopsy", "label": "Endoscopy and biopsy procedures", "api_url": "https://www.edgepedia.org/api/v1/topics/life.health.clinical.clinical-endoscopy-biopsy" }, { "id": "life.health.clinical.clinical-endoscopy-biopsy.endoscopic-resection-and-advanced-therapeutic-en", "label": "Endoscopic resection and advanced therapeutic endoscopy", "api_url": "https://www.edgepedia.org/api/v1/topics/life.health.clinical.clinical-endoscopy-biopsy.endoscopic-resection-and-advanced-therapeutic-en" } ], "geo": [ { "id": "geo.asia.t2001.life.health", "label": "Asia (other) · 2001 to 2020: Human health and medicine", "api_url": "https://www.edgepedia.org/api/v1/geo/geo.asia.t2001.life.health", "path": [ { "id": "geo.asia", "label": "Asia (other)", "api_url": "https://www.edgepedia.org/api/v1/geo/geo.asia" }, { "id": "geo.asia.t2001", "label": "Asia (other) · 2001 to 2020", "api_url": "https://www.edgepedia.org/api/v1/geo/geo.asia.t2001" }, { "id": "geo.asia.t2001.life", "label": "Life and health", "api_url": "https://www.edgepedia.org/api/v1/geo/geo.asia.t2001.life" }, { "id": "geo.asia.t2001.life.health", "label": "Human health and medicine", "api_url": "https://www.edgepedia.org/api/v1/geo/geo.asia.t2001.life.health" } ] } ], "excerpt": "Per-oral endoscopic myotomy (POEM) is an endoscopic procedure treating achalasia by dividing the lower esophageal sphincter muscle through a submucosal tunnel, with no skin incisions.", "snippet": "Per-oral endoscopic myotomy (POEM) is an endoscopic procedure treating achalasia by dividing the lower esophageal sphincter muscle through a submucosal tunnel, with no skin incisions.", "node": "life.health.clinical.clinical-endoscopy-biopsy.endoscopic-resection-and-advanced-therapeutic-en", "markdown": "# Per-oral endoscopic myotomy\n\nPer-oral endoscopic myotomy (POEM) is an endoscopic surgical procedure that divides the muscle of the lower esophageal sphincter through a tunnel created beneath the esophageal lining, treating achalasia and related spastic motility disorders without any skin incisions.[1](https://pmc.ncbi.nlm.nih.gov/articles/PMC8130836/) Since the first human procedure in 2008 it has become one of the standard treatments for achalasia, with more than 6,000 cases reported worldwide by 2021.[2](https://www.sages.org/publications/guidelines/update-to-guidelines-for-the-use-of-poem-for-achalasia/)\n\n| Key fact | Detail |\n|---|---|\n| What it does | Divides the circular muscle of the lower esophageal sphincter and gastric cardia via a submucosal tunnel, with no skin incisions[1](https://pmc.ncbi.nlm.nih.gov/articles/PMC8130836/) |\n| Main steps | Mucosotomy, submucosal tunneling, myotomy, closure of the mucosal defect[1](https://pmc.ncbi.nlm.nih.gov/articles/PMC8130836/) |\n| First human procedure | 2008, by Inoue and colleagues; termed POEM in the 2010 publication[1](https://pmc.ncbi.nlm.nih.gov/articles/PMC8130836/) |\n| Short-term success | 98% pooled (Eckardt score ≤3) across 2,373 patients; 94% at 3 months and 91% at 12 months in an updated meta-analysis[3](http://www.thieme-connect.de/products/ejournals/html/10.1055/s-0042-114426) • [4](http://www.ncbi.nlm.nih.gov/pubmed/38523886) |\n| Long-term success | 87.1% pooled at median follow-up ≥5 years (16 studies, 2,421 patients)[5](https://link.springer.com/article/10.1007/s00464-026-12618-7) |\n| Main trade-off | Higher reflux than Heller myotomy with fundoplication: esophagitis 57% vs 20% at 3 months in a randomized trial[6](https://www.nejm.org/doi/full/10.1056/NEJMoa1905380) |\n| Guideline position (2024) | Conditional recommendation for POEM or Heller myotomy in achalasia types I and II; POEM favored for type III[2](https://www.sages.org/publications/guidelines/update-to-guidelines-for-the-use-of-poem-for-achalasia/) |\n\n## How it works\n\nCutting the circular muscle of the distal esophagus and gastric cardia lowers the pressure of the lower esophageal sphincter. The effect is measurable: in patients who had undergone a prior endoscopic intervention, the LES pressure fell by 19.74 mm Hg (95% CI 14.10–25.39) after POEM, and the mean Eckardt score, a 0–12 symptom score combining weight loss, dysphagia, regurgitation, and chest pain, fell from 6.65 ± 1.92 to 1.82 ± 1.26 in long-term studies.[7](https://karger.com/dsu/article/38/2/136/118028/The-Effect-of-Peroral-Endoscopic-Myotomy-in) • [5](https://link.springer.com/article/10.1007/s00464-026-12618-7)\n\nSuccess is judged by the Eckardt score, usually with a threshold of ≤3, or ≤2 in stricter definitions.[3](http://www.thieme-connect.de/products/ejournals/html/10.1055/s-0042-114426) • [8](https://onlinelibrary.wiley.com/doi/10.1111/den.13239)\n\n## How it is done\n\nThe standard technique has four sequential steps: mucosotomy, submucosal tunneling, myotomy proper, and closure of the mucosal defect.[1](https://pmc.ncbi.nlm.nih.gov/articles/PMC8130836/)\n\n1. **Mucosotomy.** After lifting the mucosa with a saline and blue dye cushion, a 2 cm incision is made 10–15 cm proximal to the gastroesophageal junction (GEJ) to enter the submucosal plane.[1](https://pmc.ncbi.nlm.nih.gov/articles/PMC8130836/) • [9](https://pmc.ncbi.nlm.nih.gov/articles/PMC5670013/)\n2. **Tunneling.** The submucosal tunnel is dissected distally with electrocautery, extending about 3 cm beyond the GEJ (2–4 cm onto the gastric cardia) so the LES is completely covered.[1](https://pmc.ncbi.nlm.nih.gov/articles/PMC8130836/) • [9](https://pmc.ncbi.nlm.nih.gov/articles/PMC5670013/)\n3. **Myotomy.** Beginning 3–5 cm distal to the mucosotomy, a 6–10 cm myotomy is performed, usually proximal to distal, most commonly as a selective division of the circular muscle; CO₂ insufflation is used throughout.[1](https://pmc.ncbi.nlm.nih.gov/articles/PMC8130836/) • [10](https://www.spg.pt/wp-content/uploads/2023/03/Per-oral-endoscopic-myotomy-ASGE-2016.pdf) In the NEJM trial the myotomy was 6–7 cm above the LES in type I and II achalasia and calibrated to the manometric extent of spasm in type III.[6](https://www.nejm.org/doi/full/10.1056/NEJMoa1905380)\n4. **Closure.** The mucosal defect is closed.[1](https://pmc.ncbi.nlm.nih.gov/articles/PMC8130836/)\n\nPOEM should be performed at experienced centers; an estimated 20–40 procedures are needed to achieve competence.[9](https://pmc.ncbi.nlm.nih.gov/articles/PMC5670013/)\n\n## Origin\n\nThe idea of endoscopic myotomy is old: Ortega, Madureri, and Perez reported a transmucosal endoscopic myotomy series in achalasia in 1980.[11](https://doi.org/10.1016/s0016-5107%2880%2973249-2) The modern precursor came from P. Pasricha and colleagues, who described submucosal endoscopic esophageal myotomy in a porcine survival model in [Endoscopy](https://www.edgepedia.org/endoscopy) in 2007.[12](https://doi.org/10.1055/s-2007-966764) • [13](https://doi.org/10.1055/s-0029-1244080) • [14](https://doi.org/10.1016/j.gie.2009.03.133) • [10](https://www.spg.pt/wp-content/uploads/2023/03/Per-oral-endoscopic-myotomy-ASGE-2016.pdf) The technique grew out of endoscopic submucosal dissection experience.[10](https://www.spg.pt/wp-content/uploads/2023/03/Per-oral-endoscopic-myotomy-ASGE-2016.pdf) Lee L. Swanström, Erwin Rieder, and Christy M. Dunst published a stepwise approach and early clinical experience in the [Journal of the American College of Surgeons](https://www.edgepedia.org/journal-of-the-american-college-of-surgeons) in 2011.[15](https://doi.org/10.1016/j.jamcollsurg.2011.09.001) Adoption was rapid, with over 6,000 cases reported worldwide by 2021.[2](https://www.sages.org/publications/guidelines/update-to-guidelines-for-the-use-of-poem-for-achalasia/)\n\n## Variants\n\n**Orientation and length.** In a survey of 16 centers, 14 favored the anterior approach (11–3 o'clock) as in Inoue's original description, with 2 using a posterior approach (5–6 o'clock).[10](https://www.spg.pt/wp-content/uploads/2023/03/Per-oral-endoscopic-myotomy-ASGE-2016.pdf) A 200-patient randomized trial found a short myotomy (8 cm) noninferior to a long one (13 cm) for clinical success at 24 months (98.0% vs 89.1% in the intention-to-treat analysis), and it shortened procedure time (40 vs 50 minutes) but did not reduce GERD.[16](https://gut.bmj.com/content/72/8/1442) A retrograde myotomy variation was described by Ponsky, Marks, and Orenstein in 2014.[17](https://doi.org/10.1007/s00464-014-3568-9)\n\n**Depth.** Full-thickness myotomy cuts the longitudinal as well as the circular muscle. Across 9 studies (1,226 patients) it carried more symptomatic reflux than modified myotomy (OR 1.58; 95% CI 1.12–2.23), and oblique fiber-sparing myotomy, tested in a randomized trial by Nabi and colleagues published in 2023, was associated with less symptomatic reflux than full-thickness POEM.[18](https://www.giejournal.org/article/S0016-5107%2825%2901837-1/abstract) • [19](https://doi.org/10.1016/j.gie.2023.08.007)\n\n**Tunnel-family extensions.** The same submucosal-tunnel approach extends to other targets. G-POEM, the first human [endoscopic pyloromyotomy](https://www.edgepedia.org/endoscopic-pyloromyotomy) for refractory gastroparesis, was reported by Khashab and colleagues in 2013.[20](https://doi.org/10.1016/j.gie.2013.07.019) Z-POEM divides the septum for [Zenker's diverticulum](https://www.edgepedia.org/zenkers-diverticulum), an approach published as a reproducible procedure for POEM endoscopists by Brieau and colleagues in 2017; pooled data show technical success 96.3% and clinical success 93.0%.[21](https://doi.org/10.1055/s-0043-105574) • [22](https://link.springer.com/article/10.1007/s11894-025-01016-z) D-POEM, per-oral endoscopic myotomy with septotomy for distal esophageal diverticula, was reported by Basile and colleagues in 2020, with technical and clinical success of 95–100% and 86–97%.[23](https://doi.org/10.1007/s00464-019-07354-0) • [22](https://link.springer.com/article/10.1007/s11894-025-01016-z) POEM-F, endoscopic myotomy combined with fundoplication as a NOTES procedure, was reported by Inoue and colleagues in 2019.[24](https://doi.org/10.1055/a-0820-2731)\n\n## Applications\n\nPooled short-term clinical success is high: 98% (95% CI 97–100%) in the Akintoye meta-analysis of 2,373 patients, 94% at 3 months and 91% at 12 months in an updated analysis of 1,753 patients.[3](http://www.thieme-connect.de/products/ejournals/html/10.1055/s-0042-114426) • [4](http://www.ncbi.nlm.nih.gov/pubmed/38523886) Long-term data show gradual attrition: pooled success of 87.1% at median follow-up ≥5 years,[5](https://link.springer.com/article/10.1007/s00464-026-12618-7) Kaplan-Meier success of 90.2% at 3 years, 82.3% at 6 years, and 73.5% at 8 years in 496 patients at a European center,[25](https://www.em-consulte.com/article/1733851/tableaux/long-term-clinical-evaluation-of-a-decade-with-per) and 74% at a median 10-year follow-up in a Danish cohort, where most failures occurred within three months and no new failures appeared after 5 years.[26](https://www.springermedizin.de/peroral-endoscopic-myotomy-a-danish-single-center-10-year-follow/51111652)\n\nSafety is good: in 1,826 patients, mild, moderate, and severe adverse events occurred at 6.4%, 1.7%, and 0.5%.[9](https://pmc.ncbi.nlm.nih.gov/articles/PMC5670013/)\n\n**Patient selection.** For balloon dilation, surgery, or botulinum toxin, success varies strongly by Chicago type (type II 91–100%, type I 56–85%, type III 29–86%), whereas POEM showed no difference in success by type; beginners are nonetheless advised to start with straight-type achalasia rather than type III.[8](https://onlinelibrary.wiley.com/doi/10.1111/den.13239) In type III achalasia, POEM outperformed [Heller myotomy](https://www.edgepedia.org/heller-myotomy) in a multicenter comparison: clinical response 98% vs 80%, procedure time 102 vs 264 minutes, myotomy length 16 vs 8 cm, adverse events 6% vs 27%.[1](https://pmc.ncbi.nlm.nih.gov/articles/PMC8130836/) For spastic disorders, pooled clinical success is about 90%, with diffuse esophageal spasm at 88% and hypercontractile (jackhammer) esophagus at 72%.[22](https://link.springer.com/article/10.1007/s11894-025-01016-z)\n\n## Limitations and alternatives\n\nReflux is POEM's main trade-off. In the 221-patient NEJM randomized trial, clinical success at 2 years was 83.0% after POEM versus 81.7% after laparoscopic Heller myotomy (LHM) with Dor fundoplication (noninferiority P=0.007), but reflux esophagitis was more frequent after POEM at 3 months (57% vs 20%) and 24 months (44% vs 29%).[6](https://www.nejm.org/doi/full/10.1056/NEJMoa1905380) At 5 years, success was 75.0% vs 70.8%, esophagitis 41% vs 31%, and abnormal acid exposure (>4.5%) 62% vs 31%; peptic stricture, [Barrett's esophagus](https://www.edgepedia.org/barretts-esophagus), and adenocarcinoma were not reported in that follow-up.[27](https://www.thelancet.com/journals/langas/article/PIIS2468-1253%2825%2900012-3/abstract) The mechanistic difference is that Heller requires division of the phrenoesophageal ligament and short gastric vessels and is paired with a fundoplication, while POEM leaves no anti-reflux wrap; POEM's advantages include no abdominal incisions, faster recovery, easier longer myotomy, and avoidance of vagal injury.[9](https://pmc.ncbi.nlm.nih.gov/articles/PMC5670013/)\n\nAgainst pneumatic dilation, a randomized trial in treatment-naïve achalasia found 92% of POEM patients in remission at 1 year versus 70% after dilation, with esophagitis in 48% vs 13%.[9](https://pmc.ncbi.nlm.nih.gov/articles/PMC5670013/) Pooled 5-year success is about 87.1% for POEM, roughly 82.6% for Heller myotomy, and about 53% for pneumatic dilation in one report.[5](https://link.springer.com/article/10.1007/s00464-026-12618-7) Heller without fundoplication itself produces reflux in roughly 30% or more when objectively diagnosed.[2](https://www.sages.org/publications/guidelines/update-to-guidelines-for-the-use-of-poem-for-achalasia/)\n\nThe 2024 SAGES guideline conditionally recommends either POEM with appropriate [proton-pump inhibitor](https://www.edgepedia.org/proton-pump-inhibitor) use or Heller myotomy with fundoplication for achalasia subtypes I and II, favors POEM for subtype III, and conditionally recommends POEM over pneumatic dilation in adults.[2](https://www.sages.org/publications/guidelines/update-to-guidelines-for-the-use-of-poem-for-achalasia/) Anti-reflux adjuncts such as transoral incisionless fundoplication combined with POEM, POEM-F, and cTIF remain investigational.[22](https://link.springer.com/article/10.1007/s11894-025-01016-z) The SAGES panel found no indication for long-term surveillance after POEM because squamous cell carcinoma reports are low, but no meaningful data exist on long-term adenocarcinoma rates.[2](https://www.sages.org/publications/guidelines/update-to-guidelines-for-the-use-of-poem-for-achalasia/)\n\n## References\n\n1. [Peroral endoscopic myotomy: techniques and outcomes](https://pmc.ncbi.nlm.nih.gov/articles/PMC8130836/)\n2. [2024 Update to SAGES Guidelines for the Use of Peroral Endoscopic Myotomy (POEM) in the Treatment of Achalasia](https://www.sages.org/publications/guidelines/update-to-guidelines-for-the-use-of-poem-for-achalasia/)\n3. [Peroral endoscopic myotomy: a meta-analysis (Endoscopy 2016, Akintoye et al.)](http://www.thieme-connect.de/products/ejournals/html/10.1055/s-0042-114426)\n4. [Efficacy and Safety of POEM in Achalasia: An Updated Meta-analysis (Middle East J Dig Dis 2023)](http://www.ncbi.nlm.nih.gov/pubmed/38523886)\n5. [Long-term outcomes of peroral endoscopic myotomy for achalasia: a systematic review and meta-analysis with median follow-up ≥ 5 years (Surg Endosc 2026)](https://link.springer.com/article/10.1007/s00464-026-12618-7)\n6. [Endoscopic or Surgical Myotomy in Patients with Idiopathic Achalasia (NEJM 2019, randomized noninferiority trial)](https://www.nejm.org/doi/full/10.1056/NEJMoa1905380)\n7. [The Effect of POEM in Achalasia Patients with Prior Endoscopic Intervention: A Systematic Review and Meta-Analysis (Dig Surg 2021)](https://karger.com/dsu/article/38/2/136/118028/The-Effect-of-Peroral-Endoscopic-Myotomy-in)\n8. [Clinical practice guidelines for peroral endoscopic myotomy (Japan Gastroenterological Endoscopy Society)](https://onlinelibrary.wiley.com/doi/10.1111/den.13239)\n9. [Clinical Practice Update: The Use of Per-Oral Endoscopic Myotomy in Achalasia (AGA Expert Review)](https://pmc.ncbi.nlm.nih.gov/articles/PMC5670013/)\n10. [Per-oral endoscopic myotomy (with video), ASGE technology review, Gastrointestinal Endoscopy 2016](https://www.spg.pt/wp-content/uploads/2023/03/Per-oral-endoscopic-myotomy-ASGE-2016.pdf)\n11. [Endoscopic myotomy in the treatment of achalasia (Gastrointestinal Endoscopy, 1980)](https://doi.org/10.1016/s0016-5107%2880%2973249-2)\n12. [P. Pasricha and colleagues (2007). Submucosal endoscopic esophageal myotomy: a novel experimental approach for the treatment of achalasia. Endoscopy.](https://doi.org/10.1055/s-2007-966764)\n13. [H. Inoue and colleagues (2010). Peroral endoscopic myotomy (POEM) for esophageal achalasia. Endoscopy.](https://doi.org/10.1055/s-0029-1244080)\n14. [Haruhiro Inoue and colleagues (2009). First Clinical Experience of Submucosal Endoscopic Esophageal Myotomy for Esophageal Achalasia with No Skin Incision. Gastrointestinal Endoscopy.](https://doi.org/10.1016/j.gie.2009.03.133)\n15. [Lee L. Swanström, Erwin Rieder, Christy M. Dunst (2011). A Stepwise Approach and Early Clinical Experience in Peroral Endoscopic Myotomy for the Treatment of Achalasia and Esophageal Motility Disorders. Journal of the American College of Surgeons.](https://doi.org/10.1016/j.jamcollsurg.2011.09.001)\n16. [Long versus short peroral endoscopic myotomy for the treatment of achalasia: results of a non-inferiority randomised controlled trial (Gut)](https://gut.bmj.com/content/72/8/1442)\n17. [Jeffrey L. Ponsky, Jeffrey M. Marks, Sean B. Orenstein (2014). Retrograde myotomy: a variation in per oral endoscopic myotomy (POEM) technique. Surgical Endoscopy.](https://doi.org/10.1007/s00464-014-3568-9)\n18. [abstract (giejournal.org)](https://www.giejournal.org/article/S0016-5107%2825%2901837-1/abstract)\n19. [Zaheer Nabi and colleagues (2023). Conventional versus oblique fiber-sparing endoscopic myotomy for achalasia cardia: a randomized controlled trial (with videos). Gastrointestinal Endoscopy.](https://doi.org/10.1016/j.gie.2023.08.007)\n20. [Mouen A. Khashab and colleagues (2013). Gastric peroral endoscopic myotomy for refractory gastroparesis: first human endoscopic pyloromyotomy (with video). Gastrointestinal Endoscopy.](https://doi.org/10.1016/j.gie.2013.07.019)\n21. [Bertrand Brieau and colleagues (2017). Submucosal tunneling endoscopic septum division for Zenker’s diverticulum: a reproducible procedure for endoscopists who perform peroral endoscopic myotomy. Endoscopy.](https://doi.org/10.1055/s-0043-105574)\n22. [Evolving Indications of Esophageal Peroral Endoscopic Myotomy (E-POEM): A Review of Expanding Applications in Esophageal Pathologies (Curr Gastroenterol Rep 2025)](https://link.springer.com/article/10.1007/s11894-025-01016-z)\n23. [Paul Basile and colleagues (2020). Per-oral endoscopic myotomy with septotomy for the treatment of distal esophageal diverticula (D-POEM). Surgical Endoscopy.](https://doi.org/10.1007/s00464-019-07354-0)\n24. [Haruhiro Inoue and colleagues (2019). Peroral endoscopic myotomy and fundoplication: a novel NOTES procedure. Endoscopy.](https://doi.org/10.1055/a-0820-2731)\n25. [Long-term clinical evaluation of a decade with peroral endoscopic myotomy at a single European tertiary center (Gastrointestinal Endoscopy, 2025)](https://www.em-consulte.com/article/1733851/tableaux/long-term-clinical-evaluation-of-a-decade-with-per)\n26. [Peroral endoscopic myotomy: a Danish single center 10-year follow-up study](https://www.springermedizin.de/peroral-endoscopic-myotomy-a-danish-single-center-10-year-follow/51111652)\n27. [abstract (thelancet.com)](https://www.thelancet.com/journals/langas/article/PIIS2468-1253%2825%2900012-3/abstract)\n\n---\n*Topic: Encyclopedia › Life and health › Human health and medicine › Clinical assessment and procedures › Endoscopy and biopsy procedures › Endoscopic resection and advanced therapeutic endoscopy*\n\n*Initially written Sep 29, 2026 · Edited: Oct 15, 2026*\n\n*Copyright 2026 EdgeChat AI, a subsidiary of Biostate AI.*\n\nLicense: Edgepedia Community License 1.0, https://www.edgepedia.org/edgepedia/license\n", "same_as": [], "url": "https://www.edgepedia.org/per-oral-endoscopic-myotomy", "markdown_url": "https://www.edgepedia.org/per-oral-endoscopic-myotomy.md", "license": { "name": "Edgepedia Community License 1.0", "url": "https://www.edgepedia.org/edgepedia/license", "summary": "Free with credit, commercial use included. AI training is open to everyone. For other uses, organizations over USD 100M in revenue or 100M monthly users license separately.", "spdx": "LicenseRef-Edgepedia-Community-1.0" }, "credit": "\"Per-oral endoscopic myotomy\", Edgepedia (EdgeChat), https://www.edgepedia.org/per-oral-endoscopic-myotomy. Edgepedia Community License 1.0.", "credit_md": "\"[Per-oral endoscopic myotomy](https://www.edgepedia.org/per-oral-endoscopic-myotomy)\", Edgepedia (EdgeChat), [https://www.edgepedia.org/per-oral-endoscopic-myotomy](https://www.edgepedia.org/per-oral-endoscopic-myotomy). [Edgepedia Community License 1.0](https://www.edgepedia.org/edgepedia/license).", "credit_html": "\"Per-oral endoscopic myotomy\", Edgepedia (EdgeChat), https://www.edgepedia.org/per-oral-endoscopic-myotomy. Edgepedia Community License 1.0.", "speakable": "Per-oral endoscopic myotomy is an endoscopic procedure treating achalasia by dividing the lower esophageal sphincter muscle through a submucosal tunnel, with no skin incisions." }