{ "id": "epte0sr42q", "slug": "tricuspid-valve-replacement", "title": "Tricuspid valve replacement", "updated": "2026-10-15", "topic_path": [ { "id": "life", "label": "Life and health", "api_url": "https://www.edgepedia.org/api/v1/topics/life" }, { "id": "life.health", "label": "Human health and medicine", "api_url": "https://www.edgepedia.org/api/v1/topics/life.health" }, { "id": "life.health.clinical", "label": "Clinical assessment and procedures", "api_url": "https://www.edgepedia.org/api/v1/topics/life.health.clinical" }, { "id": "life.health.clinical.clinical-surgery", "label": "Surgery and surgical specialties", "api_url": "https://www.edgepedia.org/api/v1/topics/life.health.clinical.clinical-surgery" }, { "id": "life.health.clinical.clinical-surgery.cardiac-and-thoracic-surgery-procedures", "label": "Cardiac and thoracic surgery procedures", "api_url": "https://www.edgepedia.org/api/v1/topics/life.health.clinical.clinical-surgery.cardiac-and-thoracic-surgery-procedures" }, { "id": "life.health.clinical.clinical-surgery.cardiac-and-thoracic-surgery-procedures.cardiac-valve-procedures", "label": "Cardiac valve procedures", "api_url": "https://www.edgepedia.org/api/v1/topics/life.health.clinical.clinical-surgery.cardiac-and-thoracic-surgery-procedures.cardiac-valve-procedures" } ], "geo": [ { "id": "geo.nongeo.t1946.life.health.clinical.clinical-surgery.cardiac-and-thoracic-surgery-procedures", "label": "Non-geographic · 1946 to 2000: Cardiac and thoracic surgery procedures", "api_url": "https://www.edgepedia.org/api/v1/geo/geo.nongeo.t1946.life.health.clinical.clinical-surgery.cardiac-and-thoracic-surgery-procedures", "path": [ { "id": "geo.nongeo", "label": "Non-geographic", "api_url": "https://www.edgepedia.org/api/v1/geo/geo.nongeo" }, { "id": "geo.nongeo.t1946", "label": "Non-geographic · 1946 to 2000", "api_url": "https://www.edgepedia.org/api/v1/geo/geo.nongeo.t1946" }, { "id": "geo.nongeo.t1946.life", "label": "Life and health", "api_url": "https://www.edgepedia.org/api/v1/geo/geo.nongeo.t1946.life" }, { "id": "geo.nongeo.t1946.life.health", "label": "Human health and medicine", "api_url": "https://www.edgepedia.org/api/v1/geo/geo.nongeo.t1946.life.health" }, { "id": "geo.nongeo.t1946.life.health.clinical", "label": "Clinical assessment and procedures", "api_url": "https://www.edgepedia.org/api/v1/geo/geo.nongeo.t1946.life.health.clinical" }, { "id": "geo.nongeo.t1946.life.health.clinical.clinical-surgery", "label": "Surgery and surgical specialties", "api_url": "https://www.edgepedia.org/api/v1/geo/geo.nongeo.t1946.life.health.clinical.clinical-surgery" }, { "id": "geo.nongeo.t1946.life.health.clinical.clinical-surgery.cardiac-and-thoracic-surgery-procedures", "label": "Cardiac and thoracic surgery procedures", "api_url": "https://www.edgepedia.org/api/v1/geo/geo.nongeo.t1946.life.health.clinical.clinical-surgery.cardiac-and-thoracic-surgery-procedures" } ] } ], "excerpt": "Tricuspid valve replacement is a cardiac surgery procedure in which a diseased tricuspid valve is replaced with a prosthetic valve, used only when repair is not feasible or has failed.", "snippet": "Tricuspid valve replacement is a cardiac surgery procedure in which a diseased tricuspid valve is replaced with a prosthetic valve, used only when repair is not feasible or has failed.", "node": "life.health.clinical.clinical-surgery.cardiac-and-thoracic-surgery-procedures.cardiac-valve-procedures", "markdown": "# Tricuspid valve replacement\n\nTricuspid valve replacement (TVR) is a procedure in cardiac surgery in which a diseased tricuspid valve is replaced with a prosthetic valve, either during open surgery or via a transcatheter system. Repair is considered the intervention of choice, and replacement is indicated only when repair is not feasible or has failed.[1](https://link.springer.com/article/10.1186/s13019-024-03014-0) [Isolated tricuspid valve surgery](https://www.edgepedia.org/isolated-tricuspid-valve-surgery) carries an operative mortality of roughly 9%.[2](https://openheart.bmj.com/content/7/1/e001227) Transcatheter replacement (TTVR) has changed this landscape: on February 1, 2024, the Edwards EVOQUE system became the first and currently only FDA-approved TTVR device in the United States,[3](https://www.fda.gov/medical-devices/recently-approved-devices/edwards-evoque-tricuspid-valve-replacement-system-p230013) and the pivotal TRISCEND II trial later reported a win ratio of 2.02 favoring TTVR over medical therapy alone at 1 year.[4](https://www.nejm.org/doi/full/10.1056/NEJMoa2401918)\n\n| Key fact | Value |\n|---|---|\n| When replacement is chosen | Only when tricuspid repair is not feasible or has failed[1](https://link.springer.com/article/10.1186/s13019-024-03014-0) |\n| Surgical TVR operative mortality | 9.9% pooled for replacement vs 8.4% for repair; early mortality 9% across 27 studies[2](https://openheart.bmj.com/content/7/1/e001227) • [5](https://www.ajconline.org/article/S0002-9149%2823%2900536-2/abstract) |\n| Mechanical vs bioprosthesis | Mechanical valves: six-fold higher thrombotic risk (RR 6.29) but 34% lower pacemaker risk[1](https://link.springer.com/article/10.1186/s13019-024-03014-0) |\n| EVOQUE device | Bovine pericardial valve, nitinol frame, 9 anchors, 28-F transfemoral delivery, sizes 44–56 mm[6](https://www.jacc.org/doi/10.1016/j.jacc.2024.10.071) |\n| TRISCEND II 1-year result | Win ratio 2.02 favoring TTVR; new pacemaker 17.4% vs 2.3%; severe bleeding 15.4% vs 5.3%[4](https://www.nejm.org/doi/full/10.1056/NEJMoa2401918) |\n| TR elimination | ≤mild TR at 1 year in 95.3% of valve recipients vs 2.3% on medical therapy[6](https://www.jacc.org/doi/10.1016/j.jacc.2024.10.071) |\n| Regulatory status | EVOQUE FDA-approved February 1, 2024; CE-certified 2023[3](https://www.fda.gov/medical-devices/recently-approved-devices/edwards-evoque-tricuspid-valve-replacement-system-p230013) • [7](https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1562658/full) |\n\n## How it works\n\nIn the transcatheter form, the EVOQUE system is a self-expanding bovine pericardial valve mounted on a nitinol frame with a fabric skirt and 9 right-ventricular anchors designed to stabilize the valve within the annulus and subvalvular apparatus.[8](https://www.ahajournals.org/doi/full/10.1161/CIR.0000000000001232) The intra-annular sealing skirt minimizes paravalvular leak, and the nine ventricular anchors engage the leaflets, subvalvular anatomy, and the annulus.[9](https://www.edwards.com/healthcare-professionals/products-services/transcatheter-mitral-tricuspid-technologies/evoque-tricuspid-valve-replacement-system/features)\n\nRight-sided hemodynamics shape the design problem. Lower systolic closing pressure and lower opening and closing forces on the tricuspid valve increase thrombosis risk compared with left-sided valves, which is why right-sided prostheses require anticoagulation.[6](https://www.jacc.org/doi/10.1016/j.jacc.2024.10.071) Anchoring is the second design constraint; currently used mechanisms fall into four types: multiple subannular anchors engaging the subvalvular apparatus and leaflets (Evoque, Cardiovalve, Trisol, MonarQ); annular anchoring with radial strength and leaflet tines (Intrepid, Topaz); an intraventricular septal anchor combined with subleaflet anchoring (LuX-Valve); and radial strength with RVOT anchoring (V-dyne).[6](https://www.jacc.org/doi/10.1016/j.jacc.2024.10.071)\n\n## How it is done\n\nSurgical TVR uses either a mechanical or a bioprosthetic valve.[1](https://link.springer.com/article/10.1186/s13019-024-03014-0) Transcatheter replacement requires large-caliber sheaths, up to 45 Fr. Transjugular access gives better alignment, transfemoral access is safer but must traverse an acute IVC–tricuspid angle, and transatrial access requires a minimally invasive right thoracotomy.[10](https://pmc.ncbi.nlm.nih.gov/articles/PMC11571394/)\n\nSizing and guidance are central to the procedure. EVOQUE valve size is based on native annulus size measured by CT, with 44, 48, 52, and 56 mm sizes delivered through a 28-F transfemoral system.[11](https://eifu.edwards.com/eifu/tmtt-production-eifus/DOC-0574379A.pdf) Intraprocedural guidance relies on fluoroscopy and transesophageal echocardiography with live 3D multiplanar reconstruction, targeting a 3D en face view with two orthogonal long-axis planes; real-time 3D intracardiac echocardiography is emerging mainly to visualize leaflet capture by the nine anchors.[12](https://www.sciencedirect.com/science/article/abs/pii/S1936879824010318) Once the capsule is retracted to expose the anchors, the valve cannot be retrieved or recaptured.[11](https://eifu.edwards.com/eifu/tmtt-production-eifus/DOC-0574379A.pdf) In TRISCEND II, all procedures used percutaneous femoral vein access, with median device time 56.5 minutes, median length of stay 3.0 days, 1.2% conversion to surgery, and 93% of patients discharged home.[13](https://assets-us-01.kc-usercontent.com/6239a81e-8f0f-0040-a1df-b4932a10f6ae/9d1e81b7-eae0-4aa9-b466-754f05fccfd9/TRISCEND%20II%201-year%20Clinical%20Data%20Summary%20%281%29.pdf)\n\n## Origin\n\nTranscatheter valve-in-valve implantation in the tricuspid position was performed using a 23 mm SAPIEN valve.[14](https://pmc.ncbi.nlm.nih.gov/articles/PMC9524678/) The NaviGate valve was a TTVR stent implanted in humans worldwide; it was implanted in two patients with a severely dilated tricuspid annulus and failed annuloplasty, both at high surgical risk.[10](https://pmc.ncbi.nlm.nih.gov/articles/PMC11571394/) • [7](https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1562658/full)\n\nThe first-in-human multicenter experience with EVOQUE was reported by [John G. Webb](https://www.edgepedia.org/john-g-webb) and colleagues in *JACC: Cardiovascular Interventions* in 2022.[15](https://doi.org/10.1016/j.jcin.2022.01.280) The orthotopic TTVR concept was reviewed by Adam B. Greenbaum, Vasilis C. Babaliaros, and Marvin H. Eng in *Interventional Cardiology Clinics* in 2021.[16](https://doi.org/10.1016/j.iccl.2021.09.009) The pivotal TRISCEND II trial was reported by [Rebecca T. Hahn](https://www.edgepedia.org/rebecca-t-hahn) and colleagues in the *New England Journal of Medicine* in 2024.[4](https://www.nejm.org/doi/full/10.1056/NEJMoa2401918)\n\n## Variants\n\nTTVR is classified as orthotopic, with the valve placed in the native annulus, or heterotopic, with the valve placed in the superior or inferior vena cava.[10](https://pmc.ncbi.nlm.nih.gov/articles/PMC11571394/) For patients unsuitable for orthotopic procedures, heterotopic replacement with the TricValve system places prostheses in both the superior and inferior vena cava.[17](https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2024.1447411/full)\n\nThe device landscape beyond EVOQUE includes the Medtronic Intrepid, a 35-F system using radial force and leaflet tines in 42 and 48 mm sizes.[6](https://www.jacc.org/doi/10.1016/j.jacc.2024.10.071) The LuX-Valve (Jenscare) uses a self-expanding nitinol stent with an atrial disc, interventricular septal anchor, and two graspers, delivered transatrially or transjugularly via 32 Fr.[10](https://pmc.ncbi.nlm.nih.gov/articles/PMC11571394/) A LuX-Valve Plus compassionate-use study of 76 patients showed lower rates of new pacemaker implantation (5.7%) and major bleeding (6.6%) than previous TTVR trials, possibly due to transjugular access and an anchoring mechanism exerting less radial force on the annulus.[18](https://link.springer.com/article/10.1007/s11936-025-01112-3) The Cardiovalve is a three-leaflet bovine pericardium system for a 32-F transfemoral approach with a dual self-expanding nitinol frame, 24 grasping points, and a Dacron-covered atrial flange.[19](https://journal.hep.com.cn/RCM/EN/10.31083/RCM25712) • [6](https://www.jacc.org/doi/10.1016/j.jacc.2024.10.071)\n\n## Applications\n\nIn the single-arm TRISCEND study of 176 patients with symptomatic ≥moderate tricuspid regurgitation, device and procedure success were 94% and 93%, and 1-year all-cause mortality was 9.4%.[6](https://www.jacc.org/doi/10.1016/j.jacc.2024.10.071) TR was reduced to mild or none/trace in 98.7% at discharge and maintained through 1 year, when 93.3% were NYHA class I/II with a 25.7-point KCCQ improvement.[6](https://www.jacc.org/doi/10.1016/j.jacc.2024.10.071)\n\nTRISCEND II randomized 400 patients with severe symptomatic TR 2:1 to EVOQUE plus medical therapy (n=267) or medical therapy alone (n=133).[4](https://www.nejm.org/doi/full/10.1056/NEJMoa2401918) At 1 year, all-cause mortality was 12.6% vs 15.2% and heart failure hospitalization 20.9% vs 26.1% (both p>0.05); the benefit was driven by symptoms and quality of life, with a KCCQ-OS between-group difference of 17.8 points (95% CI 13.0–22.5).[20](https://www.acc.org/latest-in-cardiology/clinical-trials/2024/10/29/03/32/triscend-ii) • [4](https://www.nejm.org/doi/full/10.1056/NEJMoa2401918) In the mITT analysis at 2 years, there was no significant difference between TTVR and control in all-cause mortality (19.1% vs 25.3%; p=0.192), heart failure hospitalization (26.8% vs 32.2%; p=0.312), or the composite of all-cause mortality or heart failure hospitalization (36.0% vs 43.7%; p=0.161); the investigators noted that interpretation of these 2-year comparisons is limited by the high crossover rate.[21](https://www.pcronline.com/News/Congress-coverages/ACC/2026/TRISCEND-II-Two-Year-OutcomesTranscatheter-Tricuspid-Valve-Replacement-Severe-Tricuspid-Regurgitation) Trial patients had a mean age of 79 years and were about 76% female, over 90% with atrial fibrillation; severe pulmonary hypertension and severe right ventricular dysfunction were exclusions.[18](https://link.springer.com/article/10.1007/s11936-025-01112-3) • [22](https://clinicaltrials.gov/study/NCT04482062)\n\n## Limitations and alternatives\n\nConduction injury is the dominant procedural risk. In TRISCEND II, new permanent pacemakers were implanted in 17.4% of the valve group vs 2.3% of controls at 1 year,[4](https://www.nejm.org/doi/full/10.1056/NEJMoa2401918) and 24.7% of pacemaker-naïve patients at 30 days,[6](https://www.jacc.org/doi/10.1016/j.jacc.2024.10.071) attributed partly to subvalvular anchors and annular oversizing.[18](https://link.springer.com/article/10.1007/s11936-025-01112-3) Severe bleeding occurred in 15.4% vs 5.3% of controls.[4](https://www.nejm.org/doi/full/10.1056/NEJMoa2401918) In the TRISCEND trial, all nine patients with pre-existing pacemakers had their RV leads trapped by the Evoque valved stent, and trapped trans-tricuspid leads cannot be fully removed in case of device infection; jailing leads may be harmful in pacer-dependent or ICD patients.[7](https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1562658/full) • [10](https://pmc.ncbi.nlm.nih.gov/articles/PMC11571394/)\n\nAnticoagulation is required because low-velocity right-sided flow favors prosthetic thrombosis. The TRISCEND II protocol requires up to 6 months of warfarin targeting an INR of 2–3 plus daily 81 mg aspirin;[19](https://journal.hep.com.cn/RCM/EN/10.31083/RCM25712) in the absence of another indication for long-term oral anticoagulation, vitamin K antagonists for 6 months after TTVR are considered reasonable.[7](https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1562658/full)\n\nCompared with transcatheter edge-to-edge repair (T-TEER, TriClip), TTVR achieves more complete regurgitation reduction: pooled 1-year TR of moderate or less in 98.1% of TTVR vs 69.2% of TEER patients, with similar 30-day mortality (2.0% vs 1.2%) but more severe bleeding (23.8% vs 5.4%) and pacemaker implants (9.3% vs 1.1%).[23](https://www.annalscts.com/article/view/17468/18224) T-TEER is limited in patients with large annuli, coaptation gaps, excessive leaflet tethering, or lead-induced TR, who may require orthotopic TTVR; a coaptation gap >6–8 mm and eccentric jets predict poor TEER success.[6](https://www.jacc.org/doi/10.1016/j.jacc.2024.10.071) • [19](https://journal.hep.com.cn/RCM/EN/10.31083/RCM25712) Surgical annuloplasty remains the reference repair, and the transcatheter Cardioband, analogous to the surgical ring, was the first CE mark-approved (2018) transcatheter therapy for TR.[8](https://www.ahajournals.org/doi/full/10.1161/CIR.0000000000001232) Neither TRILUMINATE nor TRISCEND II showed a significant mortality difference vs medical therapy at 1 year.[23](https://www.annalscts.com/article/view/17468/18224)\n\n## References\n\n1. [Tricuspid valve replacement with mechanical versus biological prostheses: a systematic review and meta-analysis (Journal of Cardiothoracic Surgery, 2024)](https://link.springer.com/article/10.1186/s13019-024-03014-0)\n2. [Isolated surgical tricuspid repair versus replacement: meta-analysis of 15,069 patients (Open Heart, 2020)](https://openheart.bmj.com/content/7/1/e001227)\n3. [FDA: Edwards EVOQUE Tricuspid Valve Replacement System – P230013](https://www.fda.gov/medical-devices/recently-approved-devices/edwards-evoque-tricuspid-valve-replacement-system-p230013)\n4. [Transcatheter Valve Replacement in Severe Tricuspid Regurgitation (TRISCEND II)](https://www.nejm.org/doi/full/10.1056/NEJMoa2401918)\n5. [abstract (ajconline.org)](https://www.ajconline.org/article/S0002-9149%2823%2900536-2/abstract)\n6. [Transcatheter Tricuspid Valve Replacement (JACC State-of-the-Art Review, 2024)](https://www.jacc.org/doi/10.1016/j.jacc.2024.10.071)\n7. [Transcatheter tricuspid valve replacement: will it prevail? (Frontiers in Cardiovascular Medicine, 2025)](https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1562658/full)\n8. [The Tricuspid Valve: A Review of Pathology, Imaging, and Current Treatment Options (AHA Scientific Statement, Circulation)](https://www.ahajournals.org/doi/full/10.1161/CIR.0000000000001232)\n9. [EVOQUE System Features | Edwards Lifesciences](https://www.edwards.com/healthcare-professionals/products-services/transcatheter-mitral-tricuspid-technologies/evoque-tricuspid-valve-replacement-system/features)\n10. [Transcatheter Tricuspid Valve Replacement: Case Selection, Technical Considerations, and Procedural Planning](https://pmc.ncbi.nlm.nih.gov/articles/PMC11571394/)\n11. [Edwards EVOQUE Tricuspid Valve Replacement System, Instructions for Use](https://eifu.edwards.com/eifu/tmtt-production-eifus/DOC-0574379A.pdf)\n12. [EVOQUE Tricuspid Valve Replacement System: State-of-the-Art Screening and Intraprocedural Guidance (consensus document)](https://www.sciencedirect.com/science/article/abs/pii/S1936879824010318)\n13. [TRISCEND II 1-year Clinical Data Summary (Edwards Lifesciences)](https://assets-us-01.kc-usercontent.com/6239a81e-8f0f-0040-a1df-b4932a10f6ae/9d1e81b7-eae0-4aa9-b466-754f05fccfd9/TRISCEND%20II%201-year%20Clinical%20Data%20Summary%20%281%29.pdf)\n14. [Current Status of Transcatheter Tricuspid Valve Therapies](https://pmc.ncbi.nlm.nih.gov/articles/PMC9524678/)\n15. [John G. Webb and colleagues (2022). Transcatheter Tricuspid Valve Replacement With the EVOQUE System. JACC: Cardiovascular Interventions.](https://doi.org/10.1016/j.jcin.2022.01.280)\n16. [Adam B. Greenbaum, Vasilis C. Babaliaros, Marvin H. Eng (2021). Orthotopic Transcatheter Tricuspid Valve Replacement. Interventional Cardiology Clinics.](https://doi.org/10.1016/j.iccl.2021.09.009)\n17. [Time to assess more than prognosis: advancements and challenges in transcatheter tricuspid valve interventions (Front Cardiovasc Med, 2024)](https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2024.1447411/full)\n18. [Percutaneous Treatment Options for Tricuspid Regurgitation Therapy (Curr Treat Options Cardiovasc Med, 2025)](https://link.springer.com/article/10.1007/s11936-025-01112-3)\n19. [Transcatheter Tricuspid Valve Replacement: Current Options and Future Perspectives (Rev Cardiovasc Med)](https://journal.hep.com.cn/RCM/EN/10.31083/RCM25712)\n20. [TRISCEND II trial summary (American College of Cardiology)](https://www.acc.org/latest-in-cardiology/clinical-trials/2024/10/29/03/32/triscend-ii)\n21. [TRISCEND II: Two-year outcomes of TTVR for severe tricuspid regurgitation (PCR congress coverage, ACC 2026)](https://www.pcronline.com/News/Congress-coverages/ACC/2026/TRISCEND-II-Two-Year-OutcomesTranscatheter-Tricuspid-Valve-Replacement-Severe-Tricuspid-Regurgitation)\n22. [TRISCEND II Pivotal Trial (ClinicalTrials.gov NCT04482062)](https://clinicaltrials.gov/study/NCT04482062)\n23. [Short-term outcomes of commercial transcatheter tricuspid valve intervention: a systematic review and meta-analysis (Annals of Cardiothoracic Surgery)](https://www.annalscts.com/article/view/17468/18224)\n\n---\n*Topic: Encyclopedia › Life and health › Human health and medicine › Clinical assessment and procedures › Surgery and surgical specialties › Cardiac and thoracic surgery procedures › Cardiac valve procedures*\n\n*Initially written Sep 29, 2026 · Edited: Oct 15, 2026*\n\n*Copyright 2026 EdgeChat AI, a subsidiary of Biostate AI.*\n\nLicense: Edgepedia Community License 1.0, https://www.edgepedia.org/edgepedia/license\n", "same_as": [], "url": "https://www.edgepedia.org/tricuspid-valve-replacement", "markdown_url": "https://www.edgepedia.org/tricuspid-valve-replacement.md", "license": { "name": "Edgepedia Community License 1.0", "url": "https://www.edgepedia.org/edgepedia/license", "summary": "Free with credit, commercial use included. AI training is open to everyone. For other uses, organizations over USD 100M in revenue or 100M monthly users license separately.", "spdx": "LicenseRef-Edgepedia-Community-1.0" }, "credit": "\"Tricuspid valve replacement\", Edgepedia (EdgeChat), https://www.edgepedia.org/tricuspid-valve-replacement. Edgepedia Community License 1.0.", "credit_md": "\"[Tricuspid valve replacement](https://www.edgepedia.org/tricuspid-valve-replacement)\", Edgepedia (EdgeChat), [https://www.edgepedia.org/tricuspid-valve-replacement](https://www.edgepedia.org/tricuspid-valve-replacement). [Edgepedia Community License 1.0](https://www.edgepedia.org/edgepedia/license).", "credit_html": "\"Tricuspid valve replacement\", Edgepedia (EdgeChat), https://www.edgepedia.org/tricuspid-valve-replacement. Edgepedia Community License 1.0.", "speakable": "Tricuspid valve replacement is a cardiac surgery procedure in which a diseased tricuspid valve is replaced with a prosthetic valve, used only when repair is not feasible or has failed." }