{ "id": "epafm8sn5d", "slug": "trifluoromethylation", "title": "Trifluoromethylation", "updated": "2026-10-15", "topic_path": [ { "id": "physical", "label": "Physical world and mathematics", "api_url": "https://www.edgepedia.org/api/v1/topics/physical" }, { "id": "physical.chemistry", "label": "Chemistry", "api_url": "https://www.edgepedia.org/api/v1/topics/physical.chemistry" }, { "id": "physical.chemistry.methods", "label": "Chemical principles and methods", "api_url": "https://www.edgepedia.org/api/v1/topics/physical.chemistry.methods" }, { "id": "physical.chemistry.methods.chemical-synthesis", "label": "Chemical synthesis", "api_url": "https://www.edgepedia.org/api/v1/topics/physical.chemistry.methods.chemical-synthesis" }, { "id": "physical.chemistry.methods.chemical-synthesis.named-preparative-methods", "label": "Named synthetic methods", "api_url": "https://www.edgepedia.org/api/v1/topics/physical.chemistry.methods.chemical-synthesis.named-preparative-methods" }, { "id": "physical.chemistry.methods.chemical-synthesis.named-preparative-methods.alpha-ho-to-z", "label": "Titles Ho to Z", "api_url": "https://www.edgepedia.org/api/v1/topics/physical.chemistry.methods.chemical-synthesis.named-preparative-methods.alpha-ho-to-z" } ], "geo": [ { "id": "geo.nongeo.t1946.physical.chemistry.methods.chemical-synthesis.named-preparative-methods", "label": "Non-geographic · 1946 to 2000: Named synthetic methods", "api_url": "https://www.edgepedia.org/api/v1/geo/geo.nongeo.t1946.physical.chemistry.methods.chemical-synthesis.named-preparative-methods", "path": [ { "id": "geo.nongeo", "label": "Non-geographic", "api_url": "https://www.edgepedia.org/api/v1/geo/geo.nongeo" }, { "id": "geo.nongeo.t1946", "label": "Non-geographic · 1946 to 2000", "api_url": "https://www.edgepedia.org/api/v1/geo/geo.nongeo.t1946" }, { "id": "geo.nongeo.t1946.physical", "label": "Physical world and mathematics", "api_url": "https://www.edgepedia.org/api/v1/geo/geo.nongeo.t1946.physical" }, { "id": "geo.nongeo.t1946.physical.chemistry", "label": "Chemistry", "api_url": "https://www.edgepedia.org/api/v1/geo/geo.nongeo.t1946.physical.chemistry" }, { "id": "geo.nongeo.t1946.physical.chemistry.methods", "label": "Chemical principles and methods", "api_url": "https://www.edgepedia.org/api/v1/geo/geo.nongeo.t1946.physical.chemistry.methods" }, { "id": "geo.nongeo.t1946.physical.chemistry.methods.chemical-synthesis", "label": "Chemical synthesis", "api_url": "https://www.edgepedia.org/api/v1/geo/geo.nongeo.t1946.physical.chemistry.methods.chemical-synthesis" }, { "id": "geo.nongeo.t1946.physical.chemistry.methods.chemical-synthesis.named-preparative-methods", "label": "Named synthetic methods", "api_url": "https://www.edgepedia.org/api/v1/geo/geo.nongeo.t1946.physical.chemistry.methods.chemical-synthesis.named-preparative-methods" } ] } ], "excerpt": "Trifluoromethylation is a chemical reaction that introduces a trifluoromethyl (CF3) group into organic molecules, replacing hydrogen or halogen; 15 of the top 200 drugs of 2018 contain the group.", "snippet": "Trifluoromethylation is a chemical reaction that introduces a trifluoromethyl (CF3) group into organic molecules, replacing hydrogen or halogen; 15 of the top 200 drugs of 2018 contain the group.", "node": "physical.chemistry.methods.chemical-synthesis.named-preparative-methods.alpha-ho-to-z", "markdown": "# Trifluoromethylation\n\nTrifluoromethylation is a chemical reaction method that introduces a trifluoromethyl (CF3) group into organic molecules, replacing a hydrogen, halogen, or other leaving group on an arene, heteroarene, alkene, alkyne, or carbonyl-derived center.[1](https://beilstein-journals.org/bjoc/content/pdf/1860-5397-6-65.pdf) The CF3 group is valued in medicinal chemistry: nearly 20% of human medicines and around 30% of agrochemicals on the market contain at least one fluorine atom,[1](https://beilstein-journals.org/bjoc/content/pdf/1860-5397-6-65.pdf) and the CF3 group specifically promotes electrostatic interactions with biological targets, improves cellular membrane permeability, and increases robustness toward oxidative metabolism.[2](https://www.nature.com/articles/nature10647) Among the top 200 small-molecule pharmaceuticals by retail sales in 2018, 15 drugs contain at least one trifluoromethyl group, mostly (80%) on aryl or heteroaryl scaffolds.[3](https://www.sciencedirect.com/science/article/pii/S2666386420301454) Practice relies on four mechanistic families: nucleophilic, electrophilic, radical, and metal-mediated transfer.[1](https://beilstein-journals.org/bjoc/content/pdf/1860-5397-6-65.pdf) • [4](https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.201404005)\n\n| Key fact | Detail |\n|---|---|\n| Biological value of CF3 | Enhances target binding, membrane permeability, and oxidative metabolic stability; 15 of the top 200 drugs of 2018 carry CF3, 80% on (hetero)aryl rings [2](https://www.nature.com/articles/nature10647) • [3](https://www.sciencedirect.com/science/article/pii/S2666386420301454) |\n| Main reagent classes | TMSCF3 (nucleophilic), Togni/Umemoto salts (electrophilic), NaSO2CF3 and TFA derivatives (radical), CuCF3 (metal-mediated) [1](https://beilstein-journals.org/bjoc/content/pdf/1860-5397-6-65.pdf) • [4](https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.201404005) • [5](https://castjournals.cast.org.cn/joweb/ccl/EN/10.1016/j.cclet.2021.09.005) • [6](https://doi.org/10.1038/ncomms8919) • [7](https://pubs.acs.org/doi/full/10.1021/jo401423h) |\n| Industrial baseline | Trifluoromethylated arenes are mainly produced by the Swarts reaction, radical chlorination of aryl methyl groups followed by fluoride treatment, which lacks functional-group tolerance [8](https://pmc.ncbi.nlm.nih.gov/articles/PMC4380281/) |\n| Representative yield | Fluoroform-derived CuCF3 converts a broad range of iodoarenes at 23–50 °C in nearly quantitative yield [7](https://pubs.acs.org/doi/full/10.1021/jo401423h) |\n| Cost driver | TFAA was estimated in the 2015 study to cost $35 per kg at 1,000 kg scale [6](https://doi.org/10.1038/ncomms8919) |\n| Recent direction | Photoelectrochemical, electrochemical, and enzymatic CF3 transfer now reach 100 g scale or 99:1 e.r. [9](https://www.science.org/doi/10.1126/science.adm8902) • [10](https://www.nature.com/articles/s41467-025-56437-1) |\n\n## How it works\n\n**Nucleophilic transfer** uses trifluoromethyltrimethylsilane (Me3SiCF3, the Ruppert–Prakash reagent).[11](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/chemistry-and-synthesis/fluorination/trimethyl-trifluoromethyl) Anion-initiated addition to aldehydes and ketones proceeds through a dissociative CF3 carbanion pathway, not direct transfer from a pentacoordinate siliconate: calculations place the barrier for direct CF3 transfer from silicon above 100 kcal/mol.[12](https://pmc.ncbi.nlm.nih.gov/articles/PMC6133236/)\n\n**Electrophilic transfer** delivers a formal CF3+ species from sulfonium or iodine(III) reagents to nucleophiles.[4](https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.201404005) The mechanism is often suggested to be SN2-type at carbon, although single-electron transfer to give CF3 radicals cannot be ruled out and depends on the reagent and conditions; such electron-transfer processes extend the scope beyond conventional nucleophiles.[1](https://beilstein-journals.org/bjoc/content/pdf/1860-5397-6-65.pdf) • [4](https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.201404005)\n\n**Radical transfer** generates CF3• for attack on electron-rich π systems.[5](https://castjournals.cast.org.cn/joweb/ccl/EN/10.1016/j.cclet.2021.09.005) In the light-promoted trifluoromethylation of pyridones with Langlois' reagent, adding TEMPO suppressed product formation entirely and sparging with oxygen increased conversion, supporting a radical pathway.[13](https://par.nsf.gov/servlets/purl/10427767)\n\n**Metal-mediated transfer** relies on nucleophilic CuCF3. A Hammett study of the flow aryl-halide reaction gave a positive \\( \\rho \\) value, consistent with a nucleophilic [CuCF3] species undergoing oxidative addition with aryl iodides.[14](https://dspace.mit.edu/bitstream/handle/1721.1/93915/Buchwald_Rapid%20and%20Efficient.pdf;sequence=2) Standard Pd/Ni cross-coupling logic fails here because late-transition-metal–CF3 bonds are exceptionally strong and inert.[15](https://science-of-synthesis.thieme.com/app/text/?id=SD-213-00216)\n\n## How it is done\n\n**Copper-mediated aryl halide trifluoromethylation.** Fluoroform-derived \"ligandless\" CuCF3 trifluoromethylates a broad variety of iodoarenes at 23–50 °C in nearly quantitative yield, with high chemoselectivity (no arene, biaryl, or C2F5 side products) and gram-scale isolations up to 20 mmol.[7](https://pubs.acs.org/doi/full/10.1021/jo401423h)\n\n**Continuous-flow variant.** A flow protocol using CF3CO2K (2.0 equiv), CuI (2.0 equiv), and pyridine (2.4 equiv) in NMP at 200 °C with a 16-minute residence time gives 4-trifluoromethylbiphenyl in 87% isolated yield; it tolerates pyridines, indole, pyrimidine, pyrazine, [quinoline](https://www.edgepedia.org/quinoline), isoquinoline, and pyrazoles.[14](https://dspace.mit.edu/bitstream/handle/1721.1/93915/Buchwald_Rapid%20and%20Efficient.pdf;sequence=2)\n\n**Carbonyl addition with TMSCF3.** Ruppert reported addition to aldehydes and ketones with 10 mol % KF; a faster variant with soluble TBAF (0.6 mol %) followed.[12](https://pmc.ncbi.nlm.nih.gov/articles/PMC6133236/) Commonly an additional fluoride source (TBAF, CsF) initiates the reaction.[11](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/chemistry-and-synthesis/fluorination/trimethyl-trifluoromethyl)\n\n**Direct C–H radical trifluoromethylation.** Complex molecules are trifluoromethylated with CF3• generated from NaSO2CF3/tBuOOH or from CF3SO2Cl with Ru(phen)3(2+) under visible light.[8](https://pmc.ncbi.nlm.nih.gov/articles/PMC4380281/)\n\n## Origin\n\nThe modern reagent families emerged over four decades. Trifluoromethyltrimethylsilane was introduced by Ingo Ruppert, Klaus Schlich, and Wolfgang Volbach in 1984 in Tetrahedron Letters.[16](https://doi.org/10.1016/s0040-4039%2801%2980208-2) Sodium trifluoromethanesulfinate under oxidative conditions was reported by Bernard R. Langlois, Eliane Laurent, and Nathalie Roidot in 1991 in Tetrahedron Letters.[17](https://doi.org/10.1016/0040-4039%2891%2980524-a) Teruo Umemoto and Sumi Ishihara reported the power-variable S-, Se-, and Te-(trifluoromethyl)dibenzothio-, -seleno-, and -tellurophenium salt system in 1993 in the [Journal of the American Chemical Society](https://www.edgepedia.org/journal-of-the-american-chemical-society).[18](https://doi.org/10.1021/ja00059a009) Patrick Eisenberger, Sebastian Gischig, and Antonio Togni reported the hypervalent iodine(III)-CF3 reagents in 2006 in Chemistry – A European Journal.[19](https://doi.org/10.1002/chem.200501052) In 2011, [David A. Nagib](https://www.edgepedia.org/david-a-nagib) and David W. C. MacMillan reported photoredox trifluoromethylation of arenes and heteroarenes in Nature,[20](https://doi.org/10.1038/nature10647) and Yining Ji and colleagues reported innate [C–H trifluoromethylation](https://www.edgepedia.org/c-h-trifluoromethylation) of heterocycles in the Proceedings of the National Academy of Sciences.[21](https://doi.org/10.1073/pnas.1109059108) G. K. Surya Prakash and colleagues reported direct nucleophilic trifluoromethylation from fluoroform in 2012 in Science.[22](https://doi.org/10.1126/science.1227859) Joel W. Beatty, James J. Douglas, Kevin P. Cole, and Corey R. J. Stephenson reported the scalable TFAA-based radical method in 2015 in Nature Communications.[6](https://doi.org/10.1038/ncomms8919) Teruo Umemoto and colleagues reported the second-generation fluorinated dibenzothiophenium salts in 2017 in The Journal of Organic Chemistry,[23](https://doi.org/10.1021/acs.joc.7b00669) Hao Jia, Andreas P. Häring, Florian Berger, Li Zhang, and Tobias Ritter the trifluoromethyl thianthrenium triflate in 2021 in the Journal of the American Chemical Society,[24](https://doi.org/10.1021/jacs.1c02606) and Jing Qi and colleagues, working with Jie Wu, the electrophotochemical TFA method in 2023 in the Journal of the American Chemical Society.[25](https://doi.org/10.1021/jacs.3c10148)\n\n## Variants\n\n**Electrophilic reagents** include Togni's 1-trifluoromethyl-1,2-benziodoxol-3-(1H)-one, Umemoto's S-(trifluoromethyl)dibenzothiophenium salts, diarylsulfonium salts, and Shibata's trifluoromethylsulfoximine salts; several are commercially available.[4](https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.201404005) • [1](https://beilstein-journals.org/bjoc/content/pdf/1860-5397-6-65.pdf) The 2017 fluorinated Umemoto salts (2,8-difluoro and 2,3,7,8-tetrafluoro) are thermally stable, one-pot-preparable, and recyclable, and trifluoromethylate carbanions, (hetero)aromatics, alkenes, alkynes, thiols, sulfinates, and phosphines.[23](https://doi.org/10.1021/acs.joc.7b00669)\n\n**Radical sources** trade selectivity for cost and stability. Langlois' reagent (NaSO2CF3) provides an electrophilic CF3 radical to electron-rich double bonds and arenes and is more stable, commercially available, and less expensive than the Togni and Umemoto-type reagents.[5](https://castjournals.cast.org.cn/joweb/ccl/EN/10.1016/j.cclet.2021.09.005) The TFAA/pyridine N-oxide/Ru(bpy)3Cl2 system costs $35 per kg (TFAA at 1,000 kg) plus $40–70 per kg for pyridine N-oxide, tolerates air and moisture, trifluoromethylates benzene in 45% yield, and was demonstrated on 100 g batch scale (35% yield, 62 h).[6](https://doi.org/10.1038/ncomms8919) Togni-type reagents are shelf-stable and non-explosive at ambient conditions but should not be heated as solids.[1](https://beilstein-journals.org/bjoc/content/pdf/1860-5397-6-65.pdf) The trifluoromethyl thianthrenium triflate shows formal CF3+, CF3•, and CF3− reactivity from one reagent.[24](https://doi.org/10.1021/jacs.1c02606)\n\n## Applications\n\nBeyond the property effects noted above, direct trifluoromethylation serves late-stage functionalization. Photoredox C–H trifluoromethylation was demonstrated on pharmaceutical agents including a uracil analog, a donepezil precursor, and flavone.[2](https://www.nature.com/articles/nature10647) Light-promoted pyridone trifluoromethylation with Langlois' reagent, DMSO, and 390 nm LEDs (no photocatalyst or additive) gave 56–93% yields across pyridones; perfluoroalkylated pyridones are pharmaceutically relevant, including the FDA-approved HIV-1 drug Pifeltro.[13](https://par.nsf.gov/servlets/purl/10427767) Fluoroform-derived CuCF3 supports gram-scale preparation of benzotrifluoride building blocks up to 20 mmol.[7](https://pubs.acs.org/doi/full/10.1021/jo401423h)\n\n## Limitations and alternatives\n\n**Intrinsic constraints.** CF3 halides (CF3I, CF3Br, CF3Cl) resist nucleophilic displacement of the heavier halogen; trifluoromethyl derivatives of Mg and Li are unstable or nonexistent because of facile α-fluoro-elimination to metal fluorides and difluorocarbene; and conventional organometallic cross-coupling strategies are challenging because the strength and stability of late-transition-metal–CF3 bonds impede transfer, although Pd- and Ni-mediated trifluoromethylation methods are known.[15](https://science-of-synthesis.thieme.com/app/text/?id=SD-213-00216)\n\n**Method-specific failure modes.** The fluoroform-derived CuCF3 reagent is destabilized by coproduced CuX in the order CuCl > CuBr > CuI; an ortho effect enhances reactivity of ortho-substituted aryl halides for R = NO2, COOH, CHO, COOEt, COCH3, OCH3, and CH3 but not CN; and aryl bromides and chlorides react only reluctantly.[7](https://pubs.acs.org/doi/full/10.1021/jo401423h) Original Umemoto salts required many synthetic steps and produced large amounts of [dibenzothiophene](https://www.edgepedia.org/dibenzothiophene) waste.[23](https://doi.org/10.1021/acs.joc.7b00669) In TMSCF3 chemistry, the bis(trifluoromethyl) siliconate inhibits the chain reaction, and traces of TMSCl raise the required initiator loading.[12](https://pmc.ncbi.nlm.nih.gov/articles/PMC6133236/) TFA's high oxidation potential complicates mild decarboxylation, and conventional reagents (Togni, Umemoto, TMSCF3, Langlois, Zn(SO2CF3)2) suffer low atom utilization and hazardous byproducts.[26](https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2025.1602003/full) With NaSO2CF3, C(sp3)–H trifluoromethylation of alkanes and asymmetric C–H trifluoromethylation had not been reported as of the review covering that reagent.[5](https://castjournals.cast.org.cn/joweb/ccl/EN/10.1016/j.cclet.2021.09.005)\n\n**Alternatives.** The industrial Swarts route (radical chlorination of aryl methyl groups followed by high-pressure hydrofluoric acid treatment) is effective but lacks functional-group tolerance, which motivates direct CF3 transfer.[6](https://doi.org/10.1038/ncomms8919) • [8](https://pmc.ncbi.nlm.nih.gov/articles/PMC4380281/) Fluoroform, a potent waste greenhouse gas, can also be upcycled to trifluorovinylamine, a C2 building block for difluoromethylated (not trifluoromethylated) products.[27](https://link.springer.com/article/10.1038/s44160-026-01001-y)\n\n**Recent developments.** An ion-shielding photoelectrocatalysis strategy adsorbs trifluoroacetate anions on a positive molybdenum-doped WO3 photoanode to prevent undesired substrate–hole electron transfer, enabling decarboxylative trifluoromethylation of sensitive (hetero)arenes with ~380 hours of photoanode stability and 100-gram synthesis in flow cells.[9](https://www.science.org/doi/10.1126/science.adm8902) Engineered flavin-dependent enzymes catalyze stereoselective hydrotrifluoromethylation and cross-electrophile coupling with the thianthrenium reagent in up to 98% yield and 99:1 e.r. without light.[10](https://www.nature.com/articles/s41467-025-56437-1)\n\n## References\n\n1. [Shelf-stable electrophilic trifluoromethylating reagents: A brief historical perspective](https://beilstein-journals.org/bjoc/content/pdf/1860-5397-6-65.pdf)\n2. [Trifluoromethylation of arenes and heteroarenes by means of photoredox catalysis (Nagib & MacMillan)](https://www.nature.com/articles/nature10647)\n3. [Photoredox Catalytic Trifluoromethylation and Perfluoroalkylation of Arenes Using Trifluoroacetic and Related Carboxylic Acids (Yin/Su/Jin)](https://www.sciencedirect.com/science/article/pii/S2666386420301454)\n4. [Recent Advances in Trifluoromethylation Reactions with Electrophilic Trifluoromethylating Reagents](https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.201404005)\n5. [Application of Langlois' reagent (NaSO2CF3) in C–H functionalisation](https://castjournals.cast.org.cn/joweb/ccl/EN/10.1016/j.cclet.2021.09.005)\n6. [Joel W. Beatty and colleagues (2015). A scalable and operationally simple radical trifluoromethylation. Nature Communications.](https://doi.org/10.1038/ncomms8919)\n7. [Trifluoromethylation of Aryl and Heteroaryl Halides with Fluoroform-Derived CuCF3: Scope, Limitations, and Mechanistic Features (Grushin group)](https://pubs.acs.org/doi/full/10.1021/jo401423h)\n8. [Investigations into Transition Metal Catalyzed Arene Trifluoromethylation Reactions (Sanford Account)](https://pmc.ncbi.nlm.nih.gov/articles/PMC4380281/)\n9. [Scalable decarboxylative trifluoromethylation by ion-shielding heterogeneous photoelectrocatalysis (Chen et al.)](https://www.science.org/doi/10.1126/science.adm8902)\n10. [Ground-state flavin-dependent enzymes catalyzed enantioselective radical trifluoromethylation](https://www.nature.com/articles/s41467-025-56437-1)\n11. [Trimethyl(trifluoromethyl)silane (Ruppert–Prakash Reagent)](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/chemistry-and-synthesis/fluorination/trimethyl-trifluoromethyl)\n12. [Anion-Initiated Trifluoromethylation by TMSCF3: Deconvolution of the Siliconate–Carbanion Dichotomy by Stopped-Flow NMR/IR](https://pmc.ncbi.nlm.nih.gov/articles/PMC6133236/)\n13. [A Light-Promoted Innate Trifluoromethylation of Pyridones and Related N-Heteroarenes](https://par.nsf.gov/servlets/purl/10427767)\n14. [Rapid and Efficient Trifluoromethylation of Aryl and Heteroaryl Halides in Flow (Buchwald group)](https://dspace.mit.edu/bitstream/handle/1721.1/93915/Buchwald_Rapid%20and%20Efficient.pdf;sequence=2)\n15. [Science of Synthesis: Trifluoromethylation (Lishchynskyi, Novák, Grushin, 2014)](https://science-of-synthesis.thieme.com/app/text/?id=SD-213-00216)\n16. [Die ersten CF3-substituierten organyl(chlor)silane (Tetrahedron Letters, 1984)](https://doi.org/10.1016/s0040-4039%2801%2980208-2)\n17. [Trifluoromethylation of aromatic compounds with sodium trifluoromethanesulfinate under oxidative conditions (Tetrahedron Letters, 1991)](https://doi.org/10.1016/0040-4039%2891%2980524-a)\n18. [Teruo Umemoto, Sumi Ishihara (1993). Power-variable electrophilic trifluoromethylating agents. S-, Se-, and Te-(trifluoromethyl)dibenzothio-, -seleno-, and -tellurophenium salt system. Journal of the American Chemical Society.](https://doi.org/10.1021/ja00059a009)\n19. [Patrick Eisenberger, Sebastian Gischig, Antonio Togni (2006). Novel 10‐I‐3 Hypervalent Iodine‐Based Compounds for Electrophilic Trifluoromethylation. Chemistry - A European Journal.](https://doi.org/10.1002/chem.200501052)\n20. [David A. Nagib, David W. C. MacMillan (2011). Trifluoromethylation of arenes and heteroarenes by means of photoredox catalysis. Nature.](https://doi.org/10.1038/nature10647)\n21. [Yining Ji and colleagues (2011). Innate C-H trifluoromethylation of heterocycles. Proceedings of the National Academy of Sciences.](https://doi.org/10.1073/pnas.1109059108)\n22. [G. K. Surya Prakash and colleagues (2012). Taming of Fluoroform: Direct Nucleophilic Trifluoromethylation of Si, B, S, and C Centers. Science.](https://doi.org/10.1126/science.1227859)\n23. [Teruo Umemoto and colleagues (2017). Powerful, Thermally Stable, One-Pot-Preparable, and Recyclable Electrophilic Trifluoromethylating Agents: 2,8-Difluoro- and 2,3,7,8-Tetrafluoro-S-(trifluoromethyl)dibenzothiophenium Salts. The Journal of Organic Chemistry.](https://doi.org/10.1021/acs.joc.7b00669)\n24. [Hao Jia and colleagues (2021). Trifluoromethyl Thianthrenium Triflate: A Readily Available Trifluoromethylating Reagent with Formal CF3+, CF3•, and CF3– Reactivity. Journal of the American Chemical Society.](https://doi.org/10.1021/jacs.1c02606)\n25. [Jing Qi and colleagues (2023). Electrophotochemical Synthesis Facilitated Trifluoromethylation of Arenes Using Trifluoroacetic Acid. Journal of the American Chemical Society.](https://doi.org/10.1021/jacs.3c10148)\n26. [Advances in photocatalytic research on decarboxylative trifluoromethylation of trifluoroacetic acid and derivatives](https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2025.1602003/full)\n27. [Fluoroform upcycling to trifluorovinylamine as a C2 reagent to prepare difluoromethylated molecules](https://link.springer.com/article/10.1038/s44160-026-01001-y)\n\n---\n*Topic: Encyclopedia › Physical world and mathematics › Chemistry › Chemical principles and methods › Chemical synthesis › Named synthetic methods › Titles Ho to Z*\n\n*Initially written Sep 29, 2026 · Edited: Oct 15, 2026*\n\n*Copyright 2026 EdgeChat AI, a subsidiary of Biostate AI.*\n\nLicense: Edgepedia Community License 1.0, https://www.edgepedia.org/edgepedia/license\n", "same_as": [], "url": "https://www.edgepedia.org/trifluoromethylation", "markdown_url": "https://www.edgepedia.org/trifluoromethylation.md", "license": { "name": "Edgepedia Community License 1.0", "url": "https://www.edgepedia.org/edgepedia/license", "summary": "Free with credit, commercial use included. AI training is open to everyone. For other uses, organizations over USD 100M in revenue or 100M monthly users license separately.", "spdx": "LicenseRef-Edgepedia-Community-1.0" }, "credit": "\"Trifluoromethylation\", Edgepedia (EdgeChat), https://www.edgepedia.org/trifluoromethylation. Edgepedia Community License 1.0.", "credit_md": "\"[Trifluoromethylation](https://www.edgepedia.org/trifluoromethylation)\", Edgepedia (EdgeChat), [https://www.edgepedia.org/trifluoromethylation](https://www.edgepedia.org/trifluoromethylation). [Edgepedia Community License 1.0](https://www.edgepedia.org/edgepedia/license).", "credit_html": "\"Trifluoromethylation\", Edgepedia (EdgeChat), https://www.edgepedia.org/trifluoromethylation. Edgepedia Community License 1.0.", "speakable": "Trifluoromethylation is a chemical reaction that introduces a trifluoromethyl group into organic molecules, replacing hydrogen or halogen; 15 of the top 200 drugs of 2018 contain the group." }