# Calibrate Health
Calibrate (Calibrate Health) is a New York City-based telehealth weight-management company founded in 2020 by Isabelle Kenyon, which treats obesity with physician-prescribed GLP-1 medications combined with coaching and a lifestyle program. It was one of the first startups built to treat obesity by prescribing weight-loss drugs online, in combination with coaching.[1](https://www.businessinsider.com/weight-loss-startup-calibrate-patient-complaints-refunds-2023-9) After a distressed 2023 restructuring that left its lender in control, the company pivoted to selling obesity management to employers and health plans, and remains active as of 2026.[2](https://www.businessinsider.com/calibrate-deal-madryn-asset-management-bankruptcy-2023-11)
| Fact | Detail |
|---|---|
| Founded | 2020, by Isabelle Kenyon, out of stealth June 2020[3](https://www.forbes.com/sites/maggiemcgrath/2021/08/25/exclusive-telehealth-startup-calibrate-notches-a-100-million-series-b-from-founders-fund-and-tiger-global/) |
| Headquarters | New York City[4](https://medcitynews.com/2023/10/calibrate-obesity-ozempic-weight-loss-healthcare/) |
| Sector | Telehealth weight management (GLP-1 plus behavior change) |
| Largest funding round | $100 million Series B, August 2021, co-led by Founders Fund and Tiger Global[3](https://www.forbes.com/sites/maggiemcgrath/2021/08/25/exclusive-telehealth-startup-calibrate-notches-a-100-million-series-b-from-founders-fund-and-tiger-global/) |
| Total raised | $127.6 million as of August 2021; about $170 million per Pitchbook by late 2023 (sources disagree)[3](https://www.forbes.com/sites/maggiemcgrath/2021/08/25/exclusive-telehealth-startup-calibrate-notches-a-100-million-series-b-from-founders-fund-and-tiger-global/) • [2](https://www.businessinsider.com/calibrate-deal-madryn-asset-management-bankruptcy-2023-11) |
| 2023 restructuring | Madryn Asset Management took a 70% stake for $20 million on October 17, 2023; founder-CEO departed[2](https://www.businessinsider.com/calibrate-deal-madryn-asset-management-bankruptcy-2023-11) |
| Status (2026) | Active, enterprise-focused; company says 2026 brings first profitability[5](https://www.prnewswire.com/news-releases/calibrate-completes-transition-to-enterprise-focused-obesity-management-more-than-doubles-client-roster-302692378.html) |
## Founding and early funding
Isabelle Kenyon took Calibrate out of stealth in June 2020 with a team of ten.[3](https://www.forbes.com/sites/maggiemcgrath/2021/08/25/exclusive-telehealth-startup-calibrate-notches-a-100-million-series-b-from-founders-fund-and-tiger-global/) By January 2021 Kenyon had raised a $22.5 million Series A and grown the team to 52 people.[3](https://www.forbes.com/sites/maggiemcgrath/2021/08/25/exclusive-telehealth-startup-calibrate-notches-a-100-million-series-b-from-founders-fund-and-tiger-global/)
In August 2021 Calibrate raised a $100 million Series B co-led by [Founders Fund](https://www.edgepedia.org/founders-fund) and Tiger Global, with Optum Ventures also participating, alongside existing investors Forerunner Ventures, Threshold Ventures, and Redesign Health.[3](https://www.forbes.com/sites/maggiemcgrath/2021/08/25/exclusive-telehealth-startup-calibrate-notches-a-100-million-series-b-from-founders-fund-and-tiger-global/)
## The program
Calibrate sold a year-long "metabolic reset" program for $1,749, not including the cost of the medications.[1](https://www.businessinsider.com/weight-loss-startup-calibrate-patient-complaints-refunds-2023-9) • [4](https://medcitynews.com/2023/10/calibrate-obesity-ozempic-weight-loss-healthcare/) The program combines personalized video coaching with doctor-prescribed GLP-1 drugs such as Ozempic or Wegovy.[4](https://medcitynews.com/2023/10/calibrate-obesity-ozempic-weight-loss-healthcare/) At the time of the Series B it included FDA-approved medication, doctor visits, and app-based coaching, and curriculum.[6](https://www.fiercehealthcare.com/finance/telehealth-startup-calibrate-closes-100m-funding-round-to-expand-its-weight-loss-platform) According to the company's own 2026 Results Report, Calibrate-employed clinicians provide structured GLP-1 oversight paired with member lifestyle coaching.[7](https://go.calibratehealth.com/hubfs/2026%20Results%20Report/2026_Calibrate%20Results%20Report.pdf)
## Funding by the numbers
By January 2021 Calibrate had raised a $22.5 million Series A, and in August 2021 it raised a $100 million Series B.[3](https://www.forbes.com/sites/maggiemcgrath/2021/08/25/exclusive-telehealth-startup-calibrate-notches-a-100-million-series-b-from-founders-fund-and-tiger-global/) Forbes reported total funding of $127.6 million after the Series B.[3](https://www.forbes.com/sites/maggiemcgrath/2021/08/25/exclusive-telehealth-startup-calibrate-notches-a-100-million-series-b-from-founders-fund-and-tiger-global/) Later reporting gives higher totals: MedCity News said more than $160 million in October 2023,[4](https://medcitynews.com/2023/10/calibrate-obesity-ozempic-weight-loss-healthcare/) and [Business Insider](https://www.edgepedia.org/business-insider), citing Pitchbook, put it at about $170 million.[2](https://www.businessinsider.com/calibrate-deal-madryn-asset-management-bankruptcy-2023-11) The discrepancy is unresolved in the sources.
## Crisis: shortages, refunds and layoffs, 2022 to 2023
From 2022 Calibrate struggled to get its members timely access to GLP-1 drugs, which were expensive and in short supply, and health insurers became increasingly reluctant to pay for them.[1](https://www.businessinsider.com/weight-loss-startup-calibrate-patient-complaints-refunds-2023-9) The company paid out millions of dollars in refunds in the first half of 2023 to frustrated customers, and lacked staff in crucial roles.[1](https://www.businessinsider.com/weight-loss-startup-calibrate-patient-complaints-refunds-2023-9) It fired about 250 workers in two rounds of layoffs: one in July 2022 affecting about 150 roles, and one in April 2023 affecting about 100.[1](https://www.businessinsider.com/weight-loss-startup-calibrate-patient-complaints-refunds-2023-9) • [4](https://medcitynews.com/2023/10/calibrate-obesity-ozempic-weight-loss-healthcare/)
## The 2023 restructuring
On October 17, 2023, Calibrate completed a restructuring in which Madryn Asset Management, which had already lent the startup more than $60 million, took a 70% stake in exchange for $20 million; the deal let Calibrate avoid bankruptcy.[2](https://www.businessinsider.com/calibrate-deal-madryn-asset-management-bankruptcy-2023-11) Founder Isabelle Kenyon stepped down as CEO and was left with a 2.5% stake, per the merger documents.[2](https://www.businessinsider.com/calibrate-deal-madryn-asset-management-bankruptcy-2023-11)
## Controversies and criticism
The sourced criticism concerns operations rather than litigation or regulators: a "mountain" of patient complaints and refund disputes tied to delayed drug access, understaffing in crucial roles, and the layoffs described above.[1](https://www.businessinsider.com/weight-loss-startup-calibrate-patient-complaints-refunds-2023-9) The company's direct-to-consumer model also depended on drug supply and payer coverage it did not control; the sources attribute its difficulties to drug shortages and insurers' reluctance to pay for weight-loss drugs.[1](https://www.businessinsider.com/weight-loss-startup-calibrate-patient-complaints-refunds-2023-9) No lawsuit or regulatory action appears in the record.
## Recent developments
In February 2026 Calibrate announced it had completed its transition from a direct-to-consumer model to an enterprise-focused solution serving employers, health plans, and channel partners, and said the year would result in profitability for the first time in the company's history. These are company claims.[5](https://www.prnewswire.com/news-releases/calibrate-completes-transition-to-enterprise-focused-obesity-management-more-than-doubles-client-roster-302692378.html) The company said enterprise adoption now represents approximately 90% of its business, with clients ranging from several thousand to several hundred thousand covered lives, and that its client roster more than doubled year over year.[5](https://www.prnewswire.com/news-releases/calibrate-completes-transition-to-enterprise-focused-obesity-management-more-than-doubles-client-roster-302692378.html) It also said over 100,000 members have participated in the program since launch.[5](https://www.prnewswire.com/news-releases/calibrate-completes-transition-to-enterprise-focused-obesity-management-more-than-doubles-client-roster-302692378.html)
On May 5, 2026 the company released its 2026 Results Report, drawing on more than 50,000 members from nearly six years of clinical data.[8](https://www.prnewswire.com/news-releases/calibrate-publishes-largest-real-world-four-year-analysis-of-glp-1-weight-loss-outcomes-when-paired-with-integrated-behavioral-support-302762645.html) It reports members on GLP-1s lose on average 16% of body weight in the first year (N = 37,031), 18% by year two (N = 11,132), 20% by year three (N = 2,461), and 21% by year four (N = 620).[8](https://www.prnewswire.com/news-releases/calibrate-publishes-largest-real-world-four-year-analysis-of-glp-1-weight-loss-outcomes-when-paired-with-integrated-behavioral-support-302762645.html) Earlier, at the time of the Series B, the company had reported members averaging 14% annual body weight loss against a 10% goal.[6](https://www.fiercehealthcare.com/finance/telehealth-startup-calibrate-closes-100m-funding-round-to-expand-its-weight-loss-platform) All outcome figures are company-published and self-reported, and have not been independently or peer-reviewed verified.
## References
1. Business Insider: Weight-Loss Startup Calibrate Faces Mountain of Patient Complaints and Refunds. https://www.businessinsider.com/weight-loss-startup-calibrate-patient-complaints-refunds-2023-9
2. Business Insider: Inside Calibrate's $20 Million Deal With Madryn to Avoid Bankruptcy. https://www.businessinsider.com/calibrate-deal-madryn-asset-management-bankruptcy-2023-11
3. Forbes: Exclusive: Telehealth Startup Calibrate Notches A $100 Million Series B From Founders Fund And Tiger Global. https://www.forbes.com/sites/maggiemcgrath/2021/08/25/exclusive-telehealth-startup-calibrate-notches-a-100-million-series-b-from-founders-fund-and-tiger-global/
4. MedCity News: Weight Loss Startup Calibrate Is Changing Hands. https://medcitynews.com/2023/10/calibrate-obesity-ozempic-weight-loss-healthcare/
5. PR Newswire: Calibrate Completes Transition to Enterprise-Focused Obesity Management, More Than Doubles Client Roster. https://www.prnewswire.com/news-releases/calibrate-completes-transition-to-enterprise-focused-obesity-management-more-than-doubles-client-roster-302692378.html
6. Fierce Healthcare: Telehealth startup Calibrate clinches $100M in fresh funding to expand its weight loss platform. https://www.fiercehealthcare.com/finance/telehealth-startup-calibrate-closes-100m-funding-round-to-expand-its-weight-loss-platform
7. Calibrate 2026 Results Report (company document). https://go.calibratehealth.com/hubfs/2026%20Results%20Report/2026_Calibrate%20Results%20Report.pdf
8. PR Newswire: Calibrate Publishes Largest Real-World Four-Year Analysis of GLP-1 Weight Loss Outcomes When Paired with Integrated Behavioral Support. https://www.prnewswire.com/news-releases/calibrate-publishes-largest-real-world-four-year-analysis-of-glp-1-weight-loss-outcomes-when-paired-with-integrated-behavioral-support-302762645.html
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*Topic: Encyclopedia › Society and history › Economics and business › Business and work › Business and work overview › Companies and corporations › Venture-backed startups and growth companies › Health, biotech, and medtech startups › Digital health and health IT companies › Telehealth and virtual care companies*
*Initially written Sep 17, 2026 · Edited: Oct 11, 2026; Oct 15, 2026*
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License: Edgepedia Community License 1.0, https://www.edgepedia.org/edgepedia/license