# Daniel Peeper
**Daniel S. Peeper** is a Dutch cancer biologist working in functional oncogenomics who became head of the Division of Molecular Oncology & [Immunology](https://www.edgepedia.org/immunology) at the Netherlands Cancer Institute (NKI) in 2017.[1](https://www.nki.nl/research/research-groups/daniel-peeper) He is also Professor of Functional Oncogenomics at VU University Amsterdam and a member of the Oncode Institute.[1](https://www.nki.nl/research/research-groups/daniel-peeper) According to his Netherlands Cancer Institute group page, his laboratory is known for establishing oncogene-induced senescence as a tumor-suppressive mechanism in humans and its link to inflammation, for dissecting how melanoma resists BRAF-targeted therapy, and for functional genetic screens that identify immuno-oncology drug targets.[1](https://www.nki.nl/research/research-groups/daniel-peeper)
| Fact | Detail |
|---|---|
| Current role | Head, Division of Molecular Oncology & Immunology, Netherlands Cancer Institute (since 2017); Professor of Functional Oncogenomics, VU University Amsterdam; Oncode Institute member[1](https://www.nki.nl/research/research-groups/daniel-peeper) |
| Laboratory | Established at NKI in 2002; at NKI since October 1995[2](https://oncodeinstitute.nl/research-groups/daniel-peeper-group) • [3](https://orcid.org/0000-0003-1293-3177) |
| Signature work | Oncogene-induced senescence as an in vivo tumor suppressor (Nature, 2005) and its relay by an interleukin-dependent inflammatory network (Cell, 2008)[2](https://oncodeinstitute.nl/research-groups/daniel-peeper-group); ["The essence of senescence: Figure 1"](https://doi.org/10.1101/gad.1971610), *Genes & Development*, 2010 |
| Training | PhD 1994 with Alex van der Eb (Leiden University); postdoctoral work with Mark Ewen (Dana-Farber Cancer Institute) and René Bernards (NKI)[2](https://oncodeinstitute.nl/research-groups/daniel-peeper-group) |
| Key honors | First KWF Queen Wilhelmina Award (2007); SMR Outstanding Researcher Award (2015); EMBO member (2008); Academia Europaea (2016)[2](https://oncodeinstitute.nl/research-groups/daniel-peeper-group) |
| Translation | Co-founder of the NKI/Oncode spin-offs FlindrTx[4](https://dashboard.eacr.org/event/session/person/1081689?eid=1060) and Immagene B.V. (2020)[5](https://www.eurekalert.org/news-releases/955492); collaboration with Genmab[1](https://www.nki.nl/research/research-groups/daniel-peeper) |
## Training and career
Peeper studied Medical Biology at VU University and received his PhD in 1994 in the laboratory of Alex van der Eb at [Leiden University](https://www.edgepedia.org/leiden-university), for work on adenoviral oncoproteins and cell cycle proteins.[2](https://oncodeinstitute.nl/research-groups/daniel-peeper-group) His postdoctoral training was with [Mark Ewen](https://www.edgepedia.org/mark-e-ewen) at the Dana-Farber Cancer Institute, Harvard Medical School, on Ras-dependent cell-cycle control, and he continued that work at the NKI with [René Bernards](https://www.edgepedia.org/rene-bernards).[2](https://oncodeinstitute.nl/research-groups/daniel-peeper-group) • [4](https://dashboard.eacr.org/event/session/person/1081689?eid=1060)
According to his ORCID record he has been employed at the NKI's Division of Molecular Oncology & Immunology since 1 October 1995.[3](https://orcid.org/0000-0003-1293-3177) He became Assistant Professor at the NKI in 2002, when he established his own laboratory, and Associate Professor three years later.[2](https://oncodeinstitute.nl/research-groups/daniel-peeper-group) According to Oncode Institute, he has chaired the institute's Scientific Faculty Council and served as Chair of its Translational Research Board from 2014 to 2019.[2](https://oncodeinstitute.nl/research-groups/daniel-peeper-group) • [1](https://www.nki.nl/research/research-groups/daniel-peeper)
## Representative work: oncogene-induced senescence
His laboratory discovered the physiologic relevance and mechanism of oncogene-induced senescence (OIS) as a tumor-suppressing mechanism in humans.[6](https://cell-press-symposia.com/cancer-resistance-2021/bio-peeper.html) A 2005 Nature paper showed that benign human naevi (moles) carrying mutant BRAF are held in a senescence-like cell cycle arrest, demonstrating OIS at work in human tissue.[2](https://oncodeinstitute.nl/research-groups/daniel-peeper-group) His 2006 review in the New England Journal of Medicine, Oncogene-Induced Cell Senescence, Halting on the Road to Cancer ([doi:10.1056/nejmra062285](https://doi.org/10.1056/nejmra062285)), described this growth arrest as a physiological protection against cancer with implications for benign and premalignant lesions.[7](https://doi.org/10.1056/nejmra062285)
In 2008 his group reported in Cell that senescent cells secrete inflammatory signals: OIS is relayed by an interleukin-dependent inflammatory network, connecting senescence to the inflammatory transcriptome ([doi:10.1016/j.cell.2008.03.039](https://doi.org/10.1016/j.cell.2008.03.039)).[2](https://oncodeinstitute.nl/research-groups/daniel-peeper-group) Later work showed that reduced PTEN expression abrogates OIS, a key mechanism of human melanomagenesis (Genes & Development, 2012), and identified pyruvate dehydrogenase kinase 1 (PDK1) as a critical switch for OIS execution and a drug target in melanoma (Nature, 2013).[2](https://oncodeinstitute.nl/research-groups/daniel-peeper-group) His review The essence of senescence in Genes & Development (2010, [doi:10.1101/gad.1971610](https://doi.org/10.1101/gad.1971610)) synthesizes this field.[8](https://doi.org/10.1101/gad.1971610) A 2011 perspective stated that OIS acts as a potent barrier to oncogenic transformation, operating alongside cell death programs.[9](https://doi.org/10.1111/j.1755-148x.2011.00933.x)
## Representative work: melanoma therapy resistance
BRAF inhibitors, drugs targeting the mutant BRAFV600E protein common in melanoma, produce responses that tumors eventually escape. Peeper's group identified multiple resistance mechanisms to BRAF targeted therapy operating within a single melanoma patient (EMBO Molecular Medicine, 2015) and used a melanoma patient-derived xenograft (PDX) platform to identify a further novel resistance mechanism (Cell Reports, 2016).[2](https://oncodeinstitute.nl/research-groups/daniel-peeper-group) A 2017 Nature paper dissected cancer drug addiction, in which drug-tolerant cells become dependent on the very therapy they survive, and provided proof of clinical concept.[2](https://oncodeinstitute.nl/research-groups/daniel-peeper-group) Chronic exposure of patient-derived melanoma cell lines to cytotoxic T cells enriched a pre-existing NGFR-high population that resists both immune killing and combined BRAF plus MEK inhibition, and this population was present in patients' melanomas before treatment began ([Nature Communications](https://www.edgepedia.org/nature-communications), 2020).[10](https://www.nki.nl/research/research-groups/daniel-peeper/functional-genomics-for-rational-tumor-and-immune-cell-combination-therapy)
In collaboration with the biotechnology company [Genmab](https://www.edgepedia.org/genmab), his group showed in [Nature Medicine](https://www.edgepedia.org/nature-medicine) (2018) that melanoma intratumor heterogeneity is effectively targeted by combining an AXL antibody-drug conjugate with BRAF pathway inhibitors, which act cooperatively on distinct tumor subpopulations for more durable responses.[1](https://www.nki.nl/research/research-groups/daniel-peeper)
## Immuno-oncology targets
The group's method is the function-based, genome-wide screen: turning off one gene per cell at a time across the genome to find why tumor cells resist destruction by T cells and NK cells, and to develop rational combination treatments targeting both cancer and immune cells.[10](https://www.nki.nl/research/research-groups/daniel-peeper/functional-genomics-for-rational-tumor-and-immune-cell-combination-therapy) • [5](https://www.eurekalert.org/news-releases/955492) A genome-wide CRISPR/Cas9 screen mapping hits to the tumor necrosis factor (TNF) pathway found that ablation of the top hit, TRAF2, lowers the TNF cytotoxicity threshold in tumors by redirecting [TNF signaling](https://www.edgepedia.org/tnf-signaling) toward RIPK1-dependent apoptosis, published in Cell in 2019.[10](https://www.nki.nl/research/research-groups/daniel-peeper/functional-genomics-for-rational-tumor-and-immune-cell-combination-therapy) Parallel screens under NK and CD8 T cell pressure identified all three components of the linear ubiquitination chain assembly complex (LUBAC), RNF31, RBCK1, and SHARPIN, as top hits; a small-molecule RNF31 inhibitor sensitized tumor organoids to TNF and enhanced killing of antigen-deficient tumor cells (Cell Reports Medicine, 2022).[10](https://www.nki.nl/research/research-groups/daniel-peeper/functional-genomics-for-rational-tumor-and-immune-cell-combination-therapy) Further screens identified [STUB1](https://www.edgepedia.org/stub1), an E3 ubiquitin ligase for the interferon-γ receptor whose inactivation amplifies IFNγ signaling and sensitizes tumor cells to T cells, and an NWO-XL grant ("interacT:T") funds functional dissection of the [T cell](https://www.edgepedia.org/t-cell) to tumor cell interactome.[10](https://www.nki.nl/research/research-groups/daniel-peeper/functional-genomics-for-rational-tumor-and-immune-cell-combination-therapy)
## Translation and industry
To move these targets toward the clinic, Peeper co-founded the NKI/Oncode immuno-oncology spin-off FlindrTx.[4](https://dashboard.eacr.org/event/session/person/1081689?eid=1060) In 2020 he founded a second start-up, Immagene B.V., together with the Netherlands Cancer Institute and Oncode Institute, to develop new immunotherapy medicines, and he serves as an advisor to the company.[5](https://www.eurekalert.org/news-releases/955492)
## Honors
Peeper received NWO VIDI (2002) and VICI (2006) grants, was elected an EMBO Young Investigator in 2005, and became an EMBO member in 2008.[2](https://oncodeinstitute.nl/research-groups/daniel-peeper-group) In 2015 he received the Society for Melanoma Research Outstanding Researcher Award, and in 2016 he was elected to Academia Europaea.[2](https://oncodeinstitute.nl/research-groups/daniel-peeper-group) • [1](https://www.nki.nl/research/research-groups/daniel-peeper) In 2013 he received an ERC Synergy grant of €15 million, for the development of combinatorial cancer therapy, and his work has also been supported by ERC Advanced Grants.[2](https://oncodeinstitute.nl/research-groups/daniel-peeper-group) • [1](https://www.nki.nl/research/research-groups/daniel-peeper)
## Recent work
In November 2025 his laboratory reported in Nature that the most active tumor-killing T cells in cancer specimens are those that form tight clusters with tumor cells, a population routinely filtered out when T cells are isolated for therapy. In laboratory models and in mice carrying patient-derived tumors, T cells taken from these clusters proved up to nine times more effective at destroying cancer cells than individual T cells, and purifying them may improve current tumor-infiltrating lymphocyte (TIL) therapy; a clinical protocol is being developed.[1](https://www.nki.nl/research/research-groups/daniel-peeper) • [11](https://www.oncodeinstitute.nl/news/active-immune-cells-weve-been-overlooking-new-pathway-stronger-immunotherapy)
## References
1. [Daniel Peeper Group | Netherlands Cancer Institute](https://www.nki.nl/research/research-groups/daniel-peeper)
2. [Daniel Peeper Group | Oncode Institute](https://oncodeinstitute.nl/research-groups/daniel-peeper-group)
3. [Daniel Peeper (0000-0003-1293-3177) - ORCID](https://orcid.org/0000-0003-1293-3177)
4. [Daniel Peeper - EACR Congress](https://dashboard.eacr.org/event/session/person/1081689?eid=1060)
5. [Cancer and immunotherapy – a game of cat and mouse | EurekAlert](https://www.eurekalert.org/news-releases/955492)
6. [Speaker bio, Cell Symposia: Overcoming Therapy Resistance in Cancer (2021)](https://cell-press-symposia.com/cancer-resistance-2021/bio-peeper.html)
7. [Oncogene-Induced Cell Senescence, Halting on the Road to Cancer (NEJM)](https://doi.org/10.1056/nejmra062285)
8. [The essence of senescence (Genes & Development, 2010)](https://doi.org/10.1101/gad.1971610)
9. [Oncogene-induced senescence and melanoma: where do we stand? (Pigment Cell & Melanoma Research, 2011)](https://doi.org/10.1111/j.1755-148x.2011.00933.x)
10. [Functional genomics for rational tumor and immune cell combination therapy | Netherlands Cancer Institute](https://www.nki.nl/research/research-groups/daniel-peeper/functional-genomics-for-rational-tumor-and-immune-cell-combination-therapy)
11. [The Active Immune Cells We've Been Overlooking | Oncode Institute](https://www.oncodeinstitute.nl/news/active-immune-cells-weve-been-overlooking-new-pathway-stronger-immunotherapy)
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*Topic: Encyclopedia › Life and health › Life and health scientists › Life scientists › Researchers in molecular and cell biology › Cancer biology*
*Initially written Sep 20, 2026 · Reviewed: Sep 25, 2026 · Edited: Sep 25, 2026; Oct 15, 2026 · Last review: Sep 25, 2026*
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