# David Z.I. Cherney
**David Z.I. Cherney** (David Zev Isaac Cherney) is a Canadian nephrologist and diabetes researcher who studies how kidney disease begins in people with diabetes. He is Professor of Medicine and Gabor Zellerman Chair of Nephrology Research at the [University of Toronto](https://www.edgepedia.org/university-of-toronto), and a Clinician Scientist at the [University Health Network](https://www.edgepedia.org/university-health-network) (UHN) and Mount Sinai Hospitals, where he directs the Renal Physiology Laboratory.[1](https://www.uhnresearch.ca/researcher/david-cherney) • [2](https://events.theisn.org/event/session/person/777754?eid=1006) A 2026 UHN news release describes him as Senior Scientist at UHN, while his research profile gives Clinician Scientist.[1](https://www.uhnresearch.ca/researcher/david-cherney) • [3](https://www.uhnresearch.ca/news/4-27-2026/new-drug-for-kidney-health) His work centers on SGLT2 inhibitors, a drug class that lowers glucose by blocking sugar reabsorption in the kidney, and on the kidney blood-flow changes that precede diabetic kidney disease.
| Key fact | Detail |
|---|---|
| Roles | Professor of Medicine and Gabor Zellerman Chair of Nephrology Research, University of Toronto; Clinician Scientist, UHN and Mount Sinai; director, Renal Physiology Laboratory[1](https://www.uhnresearch.ca/researcher/david-cherney) • [2](https://events.theisn.org/event/session/person/777754?eid=1006) |
| Medical registration | College of Physicians and Surgeons of Ontario since 1 July 1999; nephrology certification effective 14 September 2005[4](https://register.cpso.on.ca/physician-info/?cpsonum=73861) |
| Training | PhD in human renal physiology, Institute of Medical Science, University of Toronto, 2008; KRESCENT fellowship 2005–2008 at Toronto General Hospital under Judith Miller[1](https://www.uhnresearch.ca/researcher/david-cherney) • [5](https://kidney.ca/Krescent/Awardees/2005-Awardees/Dr-David-Cherney) |
| Signature work | Renal hemodynamic trial of empagliflozin in type 1 diabetes, Circulation (published online 2013) |
| Major awards | ASN Distinguished Researcher Award and Diabetes Canada/CIHR-INMD Young Scientist Award, 2019; Eaton Scholar Researcher of the Year, University of Toronto, 2024[2](https://events.theisn.org/event/session/person/777754?eid=1006) |
| Funding | CIHR, JDRF, Kidney Foundation of Canada, Heart and Stroke Richard Lewar Centre of Excellence, Banting and Best Diabetes Center; CIHR-KFOC-JDRF team grant 2022–2027 |[2](https://events.theisn.org/event/session/person/777754?eid=1006) • [6](https://pharmtox.utoronto.ca/faculty/david-cherney)
## Training and career
Cherney has held an active Ontario medical registration since 1 July 1999, moved to Independent Practice class on 30 June 2003, and was certified in [Nephrology](https://www.edgepedia.org/nephrology) effective 14 September 2005; his registered hospitals are Sinai Health System and University Health Network sites in Toronto.[4](https://register.cpso.on.ca/physician-info/?cpsonum=73861) Following clinical training in nephrology, he completed a PhD in human renal physiology at the Institute of Medical Science, University of Toronto, in 2008.[1](https://www.uhnresearch.ca/researcher/david-cherney) During that period he held an Ortho Biotech–KRESCENT Joint Fellowship for 2005–2008 at Toronto General Hospital under supervisor Dr. [Judith Miller](https://www.edgepedia.org/judith-miller), studying renal complications of diabetes, including the renin-angiotensin system, angiotensin II, and the enzyme PKC.[5](https://kidney.ca/Krescent/Awardees/2005-Awardees/Dr-David-Cherney) His PhD training was supported by a Kidney Foundation of Canada Scholarship and a three-year KRESCENT Fellowship.[1](https://www.uhnresearch.ca/researcher/david-cherney) According to the College of Physicians and Surgeons of Ontario register, his medical practice corporation, David Cherney Medicine Professional Corporation, received its Certificate of Authorization on 16 January 2009.[4](https://register.cpso.on.ca/physician-info/?cpsonum=73861) He is based at Toronto General Hospital, 585 University Avenue.[6](https://pharmtox.utoronto.ca/faculty/david-cherney)
## Renal Physiology Laboratory
The Renal Physiology Laboratory at Toronto General Hospital is the unit Cherney directs, and it anchors a research program on the physiological factors that initiate kidney disease in diabetes, such as renal hyperfiltration and inflammation, aligned with his integrated cardiac-renal-endocrine clinic at UHN.[1](https://www.uhnresearch.ca/researcher/david-cherney) • [8](https://torontokidneycentre.com/care-program-renal-physiology-laboratory/) He also leads large clinical trials on the causes of kidney disease in patients with diabetes, kidney, and heart disease.[8](https://torontokidneycentre.com/care-program-renal-physiology-laboratory/) The laboratory's trials use measured clearance techniques: his type 1 diabetes studies measured GFR with inulin clearance and renal plasma flow with para-aminohippurate clearance, under experimentally clamped blood glucose at euglycemic (4–6 mmol/L) and hyperglycemic (9–11 mmol/L) levels.[9](https://hsrlce.utoronto.ca/wp-content/uploads/2015/03/Renal-Hemodynamic-Effect-of-Sodium-Glucose-Cotransporter-2-Inhibition-in-Patients-With-Type-1-Diabetes-Mellitus.pdf)
## Representative work
His signature study, Renal Hemodynamic Effect of Sodium-Glucose Cotransporter 2 Inhibition in Patients With Type 1 Diabetes Mellitus ([Circulation was a roughly six-week open-label trial in which about 30 subjects were stratified by baseline GFR into hyperfiltering (GFR ≥135 mL/min/1.73 m², about 20) and normal-GFR (90–134 mL/min/1.73 m², about 10) groups.[9](https://hsrlce.utoronto.ca/wp-content/uploads/2015/03/Renal-Hemodynamic-Effect-of-Sodium-Glucose-Cotransporter-2-Inhibition-in-Patients-With-Type-1-Diabetes-Mellitus.pdf) In the hyperfiltering group, empagliflozin 25 mg daily attenuated hyperfiltration by −33 mL/min/1.73 m² under clamped euglycemia (GFR 172±23 to 139±25 mL/min/1.73 m², P<0.01); in the normal-GFR group GFR did not change, and hemoglobin A1c fell in both groups despite lower insulin doses.[9](https://hsrlce.utoronto.ca/wp-content/uploads/2015/03/Renal-Hemodynamic-Effect-of-Sodium-Glucose-Cotransporter-2-Inhibition-in-Patients-With-Type-1-Diabetes-Mellitus.pdf) A citing article prints the paper as Circulation 2014;129(5):587-597; 2013 is its online-publication year, so some records date it to 2013.[10](https://doi.org/10.1038/ki.2014.246)
## Contribution to SGLT2 inhibitor science
The mechanism his work helped establish is tubuloglomerular feedback (kidney signaling loop that adjusts filtration rate). A review listing him as corresponding author explains that SGLT2 inhibitors reduce proximal tubular sodium reabsorption, increasing sodium delivery to the [macula densa](https://www.edgepedia.org/macula-densa); this triggers tubuloglomerular feedback, afferent arteriolar vasoconstriction, and reduced hyperfiltration.[11](https://doi.org/10.1097/mnh.0000000000000084) The same review reports that SGLT2 inhibition reduced hyperfiltration in normotensive, normoalbuminuric patients with type 1 diabetes, and that in type 2 diabetes the drugs produce a modest acute eGFR decline followed by stable function and reduced albuminuria.[11](https://doi.org/10.1097/mnh.0000000000000084) His 2016 *Circulation* review, [*Sodium Glucose Cotransporter 2 Inhibitors in the Treatment of Diabetes Mellitus* synthesized the class's cardiovascular and kidney effects.[12](https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.116.021887)
A central constraint in type 1 diabetes is diabetic ketoacidosis (DKA): [SGLT2 inhibitor](https://www.edgepedia.org/sglt2-inhibitor) therapy carries a 2- to 3-fold increase in DKA risk in this population, which limited trials for years.[13](https://clinicaltrials.gov/study/NCT06217302) According to the *Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease* study, the inTandem [sotagliflozin](https://www.edgepedia.org/sotagliflozin) trial showed that an enhanced DKA monitoring and mitigation strategy can reduce DKA incidence to below 1% per year on 200 mg/day, an approach his subsequent trials adopted.[13](https://clinicaltrials.gov/study/NCT06217302)
## Funding, honors and industry roles
His operating funding has come from the [Canadian Institutes of Health Research](https://www.edgepedia.org/canadian-institutes-of-health-research) (CIHR), JDRF, the Heart and Stroke Richard Lewar Centre of Excellence and the Banting and Best Diabetes Center.[6](https://pharmtox.utoronto.ca/faculty/david-cherney) He holds a five-year combined CIHR-KFOC Team Grant–JDRF Operating Grant in diabetic kidney disease related to type 1 diabetes (2022–2027) and a University of Toronto Department of Medicine Merit Award.[2](https://events.theisn.org/event/session/person/777754?eid=1006) In 2019 he received the American Society of Nephrology Distinguished Researcher Award, from the ASN's Midcareer Awards program established that year, and the Diabetes Canada/CIHR-INMD Young Scientist Award; in 2024 he received the Eaton Scholar Researcher of the Year Award from the University of Toronto.[2](https://events.theisn.org/event/session/person/777754?eid=1006) • [14](https://uhnfoundation.ca/stories/dr-david-cherney-to-receive-asn-distinguished-researcher-award/) Disclosed industry relationships include consulting and honoraria from [Boehringer Ingelheim](https://www.edgepedia.org/boehringer-ingelheim), Lilly, Janssen, Merck, AstraZeneca, Mitsubishi-Tanabe, and Sanofi, alongside clinical trial roles in CREDENCE, TRANSLATE, BETWEEN, and DIAMOND.[7](https://www.sambuz.com/doc/the-clinical-landscape-of-ppt-presentation-799275) A CIHR Team Grant modeling project he leads on SGLT2 inhibition in type 1 diabetes declared no conflicts of interest on its data-sharing request.[15](https://vivli.org/modelling-studies-to-assess-sodium-glucose-co-transporter-2-sglt2-inhibition-effects-and-kidney-protection-in-type-1-diabetes/)
## Recent developments
**ATTEMPT** (Adolescent Type 1 Diabetes Treatment with SGLT2i for Hyperglycemia and Hyperfiltration Trial), published in [Nature Medicine](https://www.edgepedia.org/nature-medicine) in 2025, was a 22-week, double-blind, randomized, placebo-controlled trial of dapagliflozin 5 mg as an adjunct to insulin in 98 youth with type 1 diabetes aged 12–21 (53% female), with ketone monitoring and DKA risk mitigation education.[16](https://www.nature.com/articles/s41591-025-03723-6) [Dapagliflozin](https://www.edgepedia.org/dapagliflozin) reduced measured GFR by 8.8 ml/min/1.73 m² versus placebo (95% CI −12.7 to −4.8; P<0.0001), with greater attenuation at higher baseline GFR; HbA1c fell 0.47%, time in range rose 9.0%, body weight fell 2.8 kg, and there was one mild DKA case in the treatment group.[16](https://www.nature.com/articles/s41591-025-03723-6)
His group also leads **SUGARNSALT** (Sodium Glucose Co-Transport-2 Inhibition, Diabetes and Kidney Function Loss in Type 1 Diabetes), one of eight projects in CIHR's "100 Years of Insulin" initiative, with additional JDRF funding; it combines two-year clinical trials of SGLT2 inhibitors in type 1 diabetes with Danish health-records analysis and a mathematical model of kidney failure, dialysis/transplant, and heart failure risk.[17](https://kidney.ca/en/research/supported-research/sugarnsalt-project)
According to UHN Research, in March 2026 the phase 3 FINE-ONE trial of finerenone in type 1 diabetes with chronic kidney disease was published in the New England Journal of Medicine (N Engl J Med 394(10):947-957), with Cherney as lead investigator at the UHN site and a member of the international steering committee.[3](https://www.uhnresearch.ca/news/4-27-2026/new-drug-for-kidney-health) • [18](https://pubmed.ncbi.nlm.nih.gov/41780000/) In the FINE-ONE trial, over six months in about 200 randomized adults, the urinary albumin-to-creatinine ratio fell 34% with finerenone versus 12% with placebo, a 25% greater reduction (P<0.001); hyperkalemia occurred in 10.1% on finerenone versus 3.3% on placebo.[18](https://pubmed.ncbi.nlm.nih.gov/41780000/)
## References
1. [David Cherney | UHN Research](https://www.uhnresearch.ca/researcher/david-cherney)
2. [David Cherney – International Society of Nephrology Events](https://events.theisn.org/event/session/person/777754?eid=1006)
3. [New Drug for Kidney Health | UHN Research](https://www.uhnresearch.ca/news/4-27-2026/new-drug-for-kidney-health)
4. [Cherney, David Zev Isaac – College of Physicians and Surgeons of Ontario](https://register.cpso.on.ca/physician-info/?cpsonum=73861)
5. [Dr. David Cherney – Kidney Foundation of Canada KRESCENT 2005 Awardees](https://kidney.ca/Krescent/Awardees/2005-Awardees/Dr-David-Cherney)
6. [David Cherney – Department of Pharmacology and Toxicology, University of Toronto](https://pharmtox.utoronto.ca/faculty/david-cherney)
7. [The clinical landscape of managing patients with CKD (disclosed relationships slide)](https://www.sambuz.com/doc/the-clinical-landscape-of-ppt-presentation-799275)
8. [CaRE Program & Renal Physiology Laboratory – Toronto Kidney Centre](https://torontokidneycentre.com/care-program-renal-physiology-laboratory/)
9. [Renal Hemodynamic Effect of Sodium-Glucose Cotransporter 2 Inhibition in Patients With Type 1 Diabetes Mellitus (Circulation)](https://hsrlce.utoronto.ca/wp-content/uploads/2015/03/Renal-Hemodynamic-Effect-of-Sodium-Glucose-Cotransporter-2-Inhibition-in-Patients-With-Type-1-Diabetes-Mellitus.pdf)
10. [Sodium glucose cotransport-2 inhibition and intrarenal RAS activity in people with type 1 diabetes (Kidney International)](https://doi.org/10.1038/ki.2014.246)
11. [Sodium–glucose cotransporter-2 inhibition and the potential for renal protection in diabetic nephropathy (Current Opinion in Nephrology and Hypertension)](https://doi.org/10.1097/mnh.0000000000000084)
12. [Sodium Glucose Cotransporter 2 Inhibitors in the Treatment of Diabetes Mellitus (Circulation 2016)](https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.116.021887)
13. [Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease (ClinicalTrials.gov NCT06217302)](https://clinicaltrials.gov/study/NCT06217302)
14. [Dr. Cherney receives ASN Distinguished Researcher Award – UHN Foundation](https://uhnfoundation.ca/stories/dr-david-cherney-to-receive-asn-distinguished-researcher-award/)
15. [Modelling Studies to Assess SGLT2 Inhibition Effects and Kidney Protection in Type 1 Diabetes – Vivli](https://vivli.org/modelling-studies-to-assess-sodium-glucose-co-transporter-2-sglt2-inhibition-effects-and-kidney-protection-in-type-1-diabetes/)
16. [Adjunct-to-insulin therapy using SGLT2 inhibitors in youth with type 1 diabetes: a randomized controlled trial (Nature Medicine)](https://www.nature.com/articles/s41591-025-03723-6)
17. [SUGARNSALT Project – Kidney Foundation of Canada](https://kidney.ca/en/research/supported-research/sugarnsalt-project)
18. [Finerenone in Type 1 Diabetes and Chronic Kidney Disease (FINE-ONE, NEJM)](https://pubmed.ncbi.nlm.nih.gov/41780000/)
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*Topic: Encyclopedia › Life and health › Life and health scientists › Medical and health researchers › Nephrology and kidney disease researchers › Renal physiology, electrolytes, and hypertension › Renal physiology and tubular function*
*Initially written Sep 21, 2026 · Reviewed: Sep 25, 2026; Sep 30, 2026 · Edited: Sep 25, 2026; Sep 30, 2026; Oct 11, 2026; Oct 15, 2026; Oct 21, 2026; Oct 25, 2026 · Last review: Sep 30, 2026*
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