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Deleobuvir
Deleobuvir (BI 207127) is an oral nonnucleoside inhibitor of HCV NS5B RNA polymerase binding thumb-pocket 1. It reached phase 3 HCVerso trials with faldaprevir and ribavirin before Boehringer Ingelheim discontinued development.
Deleted in esophageal cancer 1
DELEC1 (deleted in esophageal cancer 1, formerly DEC1, alias CTS9) is a human long non-coding RNA gene at 9q33.1, a candidate tumor suppressor with reduced expression in esophageal squamous cell carcinoma; distinct from DLEC1 at 3p22.3.
Deletion 5q35 syndrome
Deletion 5q35 syndrome, also called distal 5q deletion or monosomy 5q35, is a rare chromosomal disorder from terminal deletions of 5q35.1-q35.3; NSD1 deletion causes Sotos syndrome, larger deletions add NKX2.5-related heart defects.
Deletion mapping
Deletion mapping is a genetic technique that localizes a gene or mutation to a chromosomal interval by testing it against a panel of strains carrying defined chromosomal deletions.
Deletions of chromosome 1
Deletions of chromosome 1 (del(1p), del(1q), 1p36 deletion syndrome, 1q21.1 microdeletion): losses of genetic material from the largest human chromosome, causing constitutional syndromes such as 1p36 deletion and somatic lesions in neuroblastoma, glioma, and myeloma.
Deletions of chromosome 10
Deletions of chromosome 10, or partial monosomy 10, are rare chromosomal disorders missing part of 10p or 10q; 10q26 deletion syndrome (OMIM 609625) involves 3.5–17 Mb deletions with developmental delay, craniofacial anomalies, and heart defects.
Deletions of chromosome 11
Deletions of chromosome 11 (ICD-11 LD44.B; partial monosomy 11) are losses of genetic material from chromosome 11's long or short arm, causing syndromes such as Jacobsen (11q terminal deletion, 1/100,000 newborns), WAGR (11p13), and Potocki-Shaffer (11p11.2).
Deletions of chromosome 13
Deletions of chromosome 13 (13q deletion syndrome, distal monosomy 13q, ICD-11 LD44.D): constitutional partial monosomy 13q causing intellectual disability, microcephaly, and malformations, plus somatic 13q14 deletions in CLL and myeloma.
Deletions of chromosome 14
Deletions of chromosome 14, also called partial monosomy 14 (ICD-11 LD44.E), are missing segments of chromosome 14, mostly the q arm, spanning proximal 14q11.2/14q12, medial 14q22q23, and distal 14q32 forms, causing developmental delay, hypotonia, microcephaly, and FOXG1 or Temple syndromes depending on region.
Deletions of chromosome 15
Deletions of chromosome 15: segmental losses causing Prader-Willi (paternal 15q11-q13), Angelman (maternal), and microdeletion syndromes at 15q11.2, 15q13.3, 15q24, and 15q26 with variable neurodevelopmental effects.
Deletions of chromosome 17
Deletions of chromosome 17 (ICD-11 LD44.H) are segmental losses of one chromosome 17 copy causing genomic disorders: Smith-Magenis (17p11.2, RAI1), Miller-Dieker (17p13.3, PAFAH1B1), 17q12 and 17q21.31 (KANSL1) microdeletion syndromes, plus acquired del17p in cancers via TP53 loss.
Deletions of chromosome 18
Deletions of chromosome 18 (18p-, distal and proximal 18q deletion syndromes, ring 18) are partial monosomies causing developmental delay, hypotonia, short stature, and variable features determined by gene dosage.
Deletions of chromosome 19
Deletions of chromosome 19, rare missing segments of the short or long arm, cause microdeletion syndromes including 19p13.13, 19q13.11, and 19q13 deletion syndromes with developmental delay, growth, and craniofacial features.
Deletions of chromosome 2
Deletions of chromosome 2 are losses of genetic material from one of the two copies of chromosome 2, producing several clinically distinct syndromes, including 2q37 deletion and SATB2-associated syndrome.
Deletions of chromosome 20
Deletions of chromosome 20 (20p/20q deletions, del(20q)) are losses of genetic material from chromosome 20, causing Alagille syndrome (JAG1, 20p12), rare 20q11.2q12 syndromes, blood-cancer-associated del(20q), and ring chromosome 20 epilepsy.
Deletions of chromosome 22
Deletions of chromosome 22 (ICD-11 LD44.N): group of chromosomal deletion disorders including 22q11.2 deletion syndrome (CATCH 22 phenotype, DiGeorge/velocardiofacial syndrome), distal 22q11.2 microdeletion, and 22q13 deletion (Phelan-McDermid syndrome), caused mainly by NAHR between low copy repeats.
Deletions of chromosome 3
Deletions of chromosome 3 (partial monosomy 3) are rare chromosomal disorders, including 3p deletion syndrome and 3q29 microdeletion syndrome, caused by loss of a chromosome 3 segment, with intellectual disability, developmental delay, and psychiatric features.
Deletions of chromosome 4
Deletions of chromosome 4 (ICD-11 LD44.4) are partial monosomies of chromosome 4, chiefly Wolf-Hirschhorn syndrome from 4p16.3 deletion (1 in 20,000-50,000 births) and 4q-syndrome, causing developmental delay, distinctive facies, and congenital anomalies.
Deletions of chromosome 5
Deletions of chromosome 5: 5p deletions cause cri du chat (5p minus) syndrome, a congenital disorder with cat-like cry and developmental delay; somatic del(5q) defines 5q- syndrome, a myelodysplastic syndrome subtype.
Deletions of chromosome 6
Deletions of chromosome 6 (ICD-11 LD44.6) are missing segments of the short (6p) or long (6q) arm, causing syndromes driven by FOXC1, DLL1, PRKN, and TBP haploinsufficiency, plus somatic del(6q) in leukemia.
Deletions of chromosome 7
Deletions of chromosome 7 (del(7), -7) are loss of all or part of chromosome 7, causing Williams syndrome (7q11.23), Saethre-Chotzen, Greig, and Silver-Russell syndromes, and common poor-prognosis loss in myeloid malignancies.
Deletions of chromosome 8
Deletions of chromosome 8 (ICD-11 LD44.8; ICD-10-CM Q93.9): chromosomal disorders from missing 8p or 8q segments, including monosomy 8p, 8p12 and 8p23.1 microdeletions, recombinant 8 syndrome, and TRPS II.
Deletions of chromosome 9
Deletions of chromosome 9 (ICD-11 LD44.9): missing segments of the short (9p) or long (9q) arm, causing Alfi/9p deletion syndrome, 9q22.3 microdeletion, Kleefstra syndrome, ring chromosome 9, and common deletions in bladder cancer.
Deletions of the short arm of chromosome 12
Deletions of the short arm of chromosome 12 (12p deletions), rare chromosomal losses including interstitial 12p deletion syndrome with an 809.94 kb minimal critical region at 12p11.23-12p11.22; distinct from tetrasomy 12p (Pallister-Killian syndrome).
Delfin (holding company)
Delfin is a Luxembourg family holding company, incorporated in 2006, through which the eight heirs of eyewear billionaire Leonardo Del Vecchio hold their controlling stake in EssilorLuxottica.
Delfín Carballo
Delfín Carballo, born in 1952, is an Argentine lawyer and banker who cofounded Banco Macro with Jorge Brito in the 1970s and chaired the bank until his 2023 resignation.
Delfin LNG
Delfin LNG is a US deepwater port project for liquefying and exporting natural gas in the Gulf of Mexico off Louisiana, licensed in March 2025.
Delfina Chaves
Delfina Chaves (Delfina Chaves Schult), Argentine actress born 1996 in Lobos, Buenos Aires; plays Queen Máxima in the Max/Videoland series Máxima (2024– ), after lead roles in Argentina, tierra de amor y venganza, Edha, and Ringo.
Delfina Gómez Álvarez
Delfina Gómez Álvarez is a Mexican politician who has served as Governor of the State of Mexico since 2023, after previously being Secretary of Public Education.
Delfine Persoon
Delfine Persoon, Belgian boxer (born 1985), WBC female lightweight champion 2014-2019 with nine defenses, lost two famous fights to Katie Taylor, also IBF lightweight titlist, worked as a police officer.