All articles starting with D
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Download manager
A download manager is application software for retrieving files over HTTP and FTP using parallel segments, resuming, and scheduling; examples include Internet Download Manager, Free Download Manager, and aria2.
Downloadable content
Downloadable content (DLC): paid digital add-on content for video games, descended from boxed expansion packs; includes expansions, season passes, and cosmetics; DLC launches roughly double base game sales and in-game/DLC spending is 77% of games revenue.
Downregulation and upregulation
Downregulation and upregulation describe decreased or increased expression of a gene product or receptor. They occur at transcriptional, post-transcriptional, translational, and epigenetic levels, and for GPCRs reflect changes in total receptor number.
Downscaling (climate modeling)
Downscaling is a family of techniques that translate coarse global climate model output, on grids of 100 to 300 km, into regional and local climate information for impact and risk assessment.
Downside Abbey
Downside Abbey is a former Benedictine monastery in Stratton-on-the-Fosse, Somerset, founded at Douai in 1606 and holding the largest monastic library and archive in the UK.
Downsizing (film)
Downsizing is a 2017 Alexander Payne sci-fi comedy-drama, written with Jim Taylor, starring Matt Damon, Kristen Wiig, Christoph Waltz, and Hong Chau, about people shrunk to five inches; Paramount released it December 22, 2017 to a 64 Metascore and $24.4M US gross.
Downslope windstorm
A downslope windstorm is a period of strong, gusty winds descending the lee side of a mountain range. The warm North American variety is the Chinook wind.
Downstait
Downstait is an American alternative metal and hard rock band best known for writing professional wrestling entrance themes, most famously "Kingdom" (2016), the entrance theme of Cody Rhodes.
Downstate (play)
Downstate is a 2018 Bruce Norris play about four convicted sex offenders in an Illinois group home, premiered at Steppenwolf, later at the National Theatre, Playwrights Horizons (award-winning 2022), and Broadway's Booth Theatre in 2026.
Downstream (petroleum industry)
Downstream, also known as the downstream oil industry, is the petroleum industry term for refining crude oil into fuels and marketing them, contrasted with upstream production.
Downstream MEP pathway enzymes (IspD–IspH)
Downstream MEP pathway enzymes IspD-IspH convert MEP to IPP and DMAPP in bacteria and plants; IspG and IspH are oxygen-sensitive [4Fe-4S] reductases absent in humans and pursued as anti-infective drug targets.
Downstream processing
Downstream processing is the sequence of operations that isolates and purifies a biological product, such as a vaccine or therapeutic protein, from cell culture or fermentation.
Downstream signal transduction
Downstream signal transduction (Reactome R-HSA-186763) is a curated human pathway describing how autophosphorylated PDGF receptors recruit SH2-domain enzymes and adaptors such as PI3K, PLC-gamma, Src, SHP2, Ras GAP, and Grb2, initiating PI3K-AKT, RAS-MAPK, and related signaling branches.
Downtempo
Downtempo: slow-beat electronic music genre (roughly 70-115 BPM, measured median 105) built on relaxed grooves and atmosphere. Related names: chillout, downbeat. Distinguished from darker, vocal-driven trip hop; spread via KLF, Cafe del Mar, and Kruder & Dorfmeister compilations.
Downton
Downton, Wiltshire: an Avon-valley village near Salisbury, unrelated to the TV series Downton Abbey, known for its Roman villa and mosaic excavated by Philip Rahtz in 1955-56, Mesolithic and Beaker finds, The Moot ringwork, medieval borough, tannery, and 1884 rail crash.
Downton Abbey
Downton Abbey: British period drama (2010-2015) by Julian Fellowes, aired on ITV and PBS Masterpiece, following the Crawley family and their servants from 1912; spawned three films (2019, 2022, 2025) and aired in over 100 territories.
Downton Abbey (film)
Downton Abbey is a 2019 British historical drama film continuing the television series, following the Crawley family as they host King George V in 1927.
Downton Abbey series 6
Downton Abbey series 6, the final season of Julian Fellowes' ITV period drama, aired in 2015-2016: eight episodes plus a Christmas special set in 1925, closing the Crawley family saga.
Downton Abbey: A New Era
Downton Abbey: A New Era (2022) is the second Downton Abbey film, directed by Simon Curtis and written by Julian Fellowes. Set in 1928, it follows a film crew shooting a silent movie at Downton and the family's trip to a French villa inherited by the Dowager Countess, grossing about $92.7 million worldwide.
Downton Abbey: The Grand Finale
Downton Abbey: The Grand Finale, also known as Downton Abbey 3, is a 2025 historical drama film, the third and final film of the Downton Abbey franchise.
Downtown
Downtown is the North American term for a city's central business district, its commercial and civic heart. The word originated in Manhattan; the article covers its rise and fall, 1980–2018 residential revival, and post-pandemic remote-work disruption.
Downtown (Macklemore & Ryan Lewis song)
Downtown (Macklemore & Ryan Lewis song), 2015 single featuring Melle Mel, Grandmaster Caz, Kool Moe Dee, and Eric Nally; lead single from This Unruly Mess I've Made, platinum, No. 12 Hot 100, MTV EMA Best Video.
Downtown (Petula Clark song)
Downtown, Petula Clark's 1964 pop single written and produced by Tony Hatch after a Times Square walk, recorded 16 October 1964 at Pye Studios with about 40 musicians; UK number 2, US Hot 100 number 1 in January 1965, 1965 Grammy winner for Best Rock & Roll Recording.
Downtown Eastside
Downtown Eastside, Vancouver, is a historic neighborhood centered on Main and Hastings Streets, home to Chinatown, Gastown, and Strathcona, and known for concentrated low-income housing and homelessness.
Downtown Honolulu
Downtown Honolulu is Oʻahu's civic and business core beside Honolulu Harbor, home to ʻIolani Palace, the State Capitol, Aloha Tower, historic Chinatown, and the future Skyline Segment 3 rail stations opening around 2031.
Downtown Julie Brown
Downtown Julie Brown (Julie Dorne Brown, born 1963) is a British-born TV personality, actress, and DJ, best known as an MTV VJ and host of Club MTV until 1992, famous for "Wubba Wubba Wubba"; later ESPN, E!, American Dance Traxx, and SiriusXM's '90s on 9. Not the comedian Julie Brown.
Downtown Los Angeles
Downtown Los Angeles (DTLA) is the city's central business district, about five to six square miles of Historic Core, Arts District, Little Tokyo, and South Park, anchored by Union Station, the Music Center, and Crypto.com Arena, with 26% of city housing added since 2010.
Downtown MRT line
The Downtown MRT line, or DTL, is a fully underground, driverless MRT in Singapore. It runs 42 km from Bukit Panjang to Expo, serving 35 stations and 11 interchanges.
Downtown music
Downtown music, or the Downtown scene, is a community of experimental musicians in Lower Manhattan, New York, active from the 1970s and centered on the Knitting Factory.
Downtown New York and loft-era jazz ensembles
Downtown New York and loft-era jazz ensembles were artist-run avant-garde groups of the 1970s Lower Manhattan lofts and the 1980s–90s downtown scene around the Knitting Factory.