All articles starting with M
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MAP4K4
MAP4K4 (HGK, NIK, MEKKK4) is a human serine/threonine Ste20-family kinase at 2q11.2 that activates JNK and Hippo signaling; a therapeutic target candidate in diabetes, atherosclerosis, heart failure, and cancer.
Mapa Quinatzin
The Mapa Quinatzin is a Nahua pictorial codex from Texcoco in the Valley of Mexico, painted around 1542 by descendants of its ruling dynasty, showing the palace of Nezahualcoyotl and Texcocan laws.
Mapam (מפ"ם)
Mapam (מפ"ם, United Workers Party) was a socialist-Zionist Israeli party founded in 1948 from HaShomer HaTzair and Ahdut HaAvoda; it won 19 seats in 1949, joined the Alignment, and merged into Meretz by 1997.
Mapfre
Mapfre is a Spanish multinational insurance group headquartered in Majadahonda, Madrid, selling life, health, property, motor, and other insurance worldwide, with 2025 written premiums of €29.1 billion.
Maphilindo
Maphilindo, an acronym of Malaya, the Philippines, and Indonesia, was a proposed loose confederation agreed at the Manila Summit of 1963 by Macapagal, Sukarno, and Tunku Abdul Rahman, and abandoned within months.
Maphra
Maphra (MAPHRA) is an anonymous American female metal vocalist known for viral cover singles, especially Bring Me the Horizon's "Doomed," which topped Billboard's Hot Hard Rock Songs and led to a 2026 Sonic Temple live debut.
MAPK docking motifs
MAPK docking motifs are short linear amino acid sequences that bind docking grooves on MAPK enzymes, determining which kinase acts on which substrate, kinase, phosphatase, or scaffold partner.
MAPK phosphatase
MAPK phosphatases (MKPs, DUSP family) are dual-specificity phosphatases that dephosphorylate threonine and tyrosine on ERK, JNK and p38 MAPKs; ten mammalian members in three classes regulate immunity, cancer, and metabolic disease.
MAPK/ERK pathway
The MAPK/ERK pathway, also called the Ras–Raf–MEK–ERK pathway, is a chain of protein kinases that relays signals from cell-surface receptors to DNA, controlling proliferation and differentiation.
MAPK1
MAPK1 (ERK2) is the human gene encoding extracellular signal-regulated kinase 2, the predominant effector kinase of the Ras-Raf-MEK-ERK cascade, functionally redundant with ERK1 (MAPK3) and essential for development.
MAPK14
MAPK14 (p38α, p38 MAP kinase alpha, aliases CSBP, SAPK2A, Mxi2) is a human stress- and cytokine-activated serine/threonine kinase gene at 6p21.31 encoding a 360-amino-acid MAPK with roughly 200-300 substrates and a long, mixed drug-development history.
MAPK3
MAPK3, also called ERK1 or p44, is a mammalian mitogen-activated protein kinase, the terminal effector of the Ras-Raf-MEK-ERK cascade, activated by MEK1/2 TEY-motif phosphorylation and implicated in about 40% of human cancers.
MAPK7
MAPK7 encodes ERK5 (BMK1), the largest conventional human MAP kinase, a dual kinase-transcription factor in the MEK5-ERK5 pathway, essential for vascular development and studied as a cancer drug target with paradoxical inhibitor activation.
MAPK8
MAPK8 (JNK1, SAPK1, HGNC:6881) is a human stress-activated serine/threonine kinase gene on 10q11.22, activated by MKK4/MKK7 dual phosphorylation of Thr-183/Tyr-185, phosphorylating c-Jun and other transcription factors in apoptosis and inflammation.
MAPK9
MAPK9 (JNK2, p54aSAPK) is a human protein-coding gene at 5q35.3 encoding c-Jun N-terminal kinase 2, a stress-activated MAPK phosphorylated by MKK4/MKK7, regulating c-Jun, p53 stability, T-cell differentiation, apoptosis, and metabolism.
MAPKAP1
MAPKAP1 (SIN1, MIP1), human gene at 9q33.3 encoding a 522-aa mTORC2 scaffold subunit required for Akt Ser473 phosphorylation, substrate recruitment, and Ras/PI3K signaling, implicated in cancer.
MAPKAPK2
MAPKAPK2 (MK2), a 400-amino-acid serine/threonine kinase activated by p38 MAPK at Thr222, Ser272, and Thr334, regulates HSP27 and tristetraprolin, TNF cytokine production, inflammation, and cancer; drug inhibitor ATI-450 reached phase 2 before 2023 discontinuation.
Maple
Maple (genus Acer, Sapindaceae), about 155 Northern Hemisphere tree species with lobed leaves and winged samaras; sugar maple and red maple dominate syrup, with Canada over 75% of world production.
Maple (software)
Maple, also known as the Maple computer algebra system, is a general-purpose mathematics software developed by Maplesoft, conceived at the University of Waterloo in November 1980.
Maple Eight
The Maple Eight are eight large Canadian public pension investment managers. They manage C$2.2 trillion in assets and are known for sophisticated global infrastructure investments.
Maple leaf
Maple leaf: the lobed leaf of Acer trees, emblem of Canada since the 19th century and centerpiece of the 11-point design on the National Flag of Canada (1965); also known for anthocyanin-driven red autumn coloration.
Maple Leaf Foods
Maple Leaf Foods Inc. is a Canadian consumer packaged goods company headquartered in Mississauga, Ontario, producing prepared meats and other foods under its own brands.
Maple Leaf Gardens
Maple Leaf Gardens, Toronto arena opened November 12, 1931, home of the Toronto Maple Leafs for 68 years until the final NHL game February 13, 1999; now a National Historic Site with a Loblaws store and TMU's Mattamy Athletic Centre.
Maple Leaf Pro Wrestling
Maple Leaf Pro Wrestling (MLP), Canadian indie promotion founded August 8, 2024 by ex-TNA president Scott D'Amore in Toronto; spiritual successor to Frank Tunney's Maple Leaf Wrestling; airs Mayhem on TSN2 and MyAEW, runs PPVs on YouTube and TrillerTV.
Maple Leaf Rag
Maple Leaf Rag is an 1899 piano rag by Scott Joplin, published in Sedalia, Missouri, whose million-copy success established his reputation and the genre's commercial model.
Maple Leaf Sports & Entertainment
Maple Leaf Sports & Entertainment (MLSE), Toronto sports conglomerate owning the Maple Leafs, Raptors, Toronto FC, and Argonauts and operating Scotiabank Arena; wholly owned by Rogers Communications since October 1, 2026.
Maple Leaves
Maple Leaves (紅葉, momiji) are the red autumn foliage of Japanese maples, a central motif in Japanese seasonal culture and painting from the sixteenth century onward.
Maple syrup
Maple syrup, a sweetener boiled down from sugar maple sap, is about 96% sucrose with over 200 identified compounds; Quebec supplies three-quarters of world production, graded into four U.S. Grade A color classes.
Maple syrup urine disease
Maple syrup urine disease (MSUD, branched-chain ketoacid dehydrogenase deficiency) is an autosomal recessive disorder blocking breakdown of leucine, isoleucine, and valine; classic neonatal form causes encephalopathy, maple syrup odor, and death if untreated, managed by BCAA-restricted diet or liver transplant.
Maple, Zayu and Clutch
Maple, Zayu and Clutch are the official mascots of FIFA World Cup 2026: Maple the Moose (Canada), Zayu the Jaguar (Mexico), and Clutch the Bald Eagle (United States), unveiled 25 September 2025 and the first FIFA mascots playable in a video game, FIFA Heroes.