All articles starting with O
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OPAL BALANCE trial
OPAL Balance (NCT01976364) is Pfizer's open-label long-term extension of tofacitinib in psoriatic arthritis, following OPAL Broaden and OPAL Beyond; its randomised methotrexate withdrawal substudy found no clinically meaningful disease activity change after stopping methotrexate.
OPAL BEYOND trial
OPAL Beyond (NCT01882439) was Pfizer's 6-month phase 3 trial of tofacitinib 5 and 10 mg twice daily versus placebo in 394 psoriatic arthritis patients with inadequate response to TNF inhibitors; ACR20 at month 3 was about 50% versus 24%.
OPAL BROADEN trial
OPAL Broaden (NCT01877668) was Pfizer's 12-month phase 3 trial of tofacitinib 5 and 10 mg twice daily versus adalimumab and placebo in 422 csDMARD-inadequate-response, TNFi-naive patients with active psoriatic arthritis.
OPaL Dahej plant
The OPaL Dahej plant is a petrochemical complex at Dahej, Gujarat, India, owned by ONGC Petro additions Limited and built around a dual-feed cracker commissioned in 2017.
OPAL Fuels Inc.
OPAL Fuels Inc. is an American renewable energy company in White Plains, New York, that converts landfill and dairy farm biogas into renewable natural gas for trucking.
OPAL Gas Pipeline
The OPAL gas pipeline (Ostsee-Pipeline-Anbindungsleitung) is a 473-kilometer natural gas pipeline in eastern Germany connecting Nord Stream 1's landfall at Lubmin to the Czech border.
OPAL-RT
OPAL-RT is a Canadian technology company founded in Montréal in 1997 that builds real-time simulators such as RT-LAB and HYPERSIM, used by utilities, automakers, and universities for hardware-in-the-loop testing.
Opala
Opala (Опала, Opalskaya Sopka) is an active stratovolcano-caldera complex in southern Kamchatka, Russia, 2,439-2,475 m high, known for its 40,000-year-old caldera, the 1400 cal BP rhyolite eruption, and OP marker tephra.
Opalin
Opalin (TMEM10, OPALIN gene) is a mammalian-specific CNS myelin protein: a 141-aa type I transmembrane sialylglycoprotein of oligodendrocyte paranodal loops that promotes oligodendrocyte differentiation and acts as the LGI1 receptor.
Opalite (song)
Opalite is a 2025 song by Taylor Swift, track three on The Life of a Showgirl, written and produced with Max Martin and Shellback. Named for man-made opal, Kelce's birthstone, it topped the UK and Billboard Hot 100 charts in 2026.
Opamtistomig
Opamtistomig (LBL-024, Chinese 奥帕替苏米单抗) is a PD-L1/4-1BB bispecific antibody from Nanjing Leads Biolabs for advanced extrapulmonary neuroendocrine carcinoma; NDA accepted by China's NMPA in August 2026 with priority review.
Opatów
Opatów, a Polish town, is known for the largest fully excavated Przeworsk culture cemetery (site 1, ~1,000 features, 300 years of use) and the Globular Amphora culture cemetery at Sadowie; also a historic Jewish community.
Opay
OPay, formerly Paycom Nigeria Limited, is a Nigeria-based fintech company offering payments, transfers, savings, and loans across Nigeria, Egypt, Indonesia, and Pakistan, with 50 million monthly active users.
OPC Energy
OPC Energy is an Israeli independent power producer founded in 2010 as the first private electricity company in Israel, now operating in the United States too.
OPC Unified Architecture
OPC Unified Architecture (OPC UA) is a platform-independent, service-oriented standard for machine-to-machine communication in industrial automation, released in 2008 and standardized internationally as IEC 62541.
OPC water model
The OPC (Optimal Point Charge) water model is a rigid, non-polarizable water model for molecular simulations, introduced in 2014 at Virginia Tech, with its three-site counterpart OPC3 following in 2016.
Opcode
An opcode, short for operation code, is the part of a machine instruction or bytecode that specifies the operation to perform, such as add, load, or branch.
Opcore
Opcore (Opcore SAS) is a French hyperscale data center company, jointly owned by iliad and InfraVia, operating about 131 MW across Paris, Lyon, Marseille, and Poland.
Ope (interjection)
Ope is a Midwestern US interjection expressing mild surprise or apology, akin to oops; analyzed as "oh" with an excrescent final /p/, also an archaic word meaning "open."
OPEC
OPEC (Organization of the Petroleum Exporting Countries) is a Vienna-based intergovernmental group founded in Baghdad in 1960 by Iran, Iraq, Kuwait, Saudi Arabia and Venezuela. Its 12 members hold over 80% of proven reserves; OPEC+ with Russia produces about 40% of world crude.
OPEC Fund for International Development
The OPEC Fund for International Development is a multilateral development finance institution, established by OPEC member countries in 1976 to finance development in countries that are not OPEC members.
OPEC+
OPEC+ is a group of OPEC and ten allied oil-producing countries, formed in 2016 to coordinate production and stabilize oil markets, producing about 40 percent of world crude.
Opechancanough
Opechancanough, who died in 1646, was paramount chief of the Powhatan Chiefdom in Virginia, known for leading surprise assaults on English colonists in 1622 and 1644.
Opel
Opel is a German automobile manufacturer headquartered in Rüsselsheim am Main, founded by Adam Opel in 1862 as a sewing-machine maker and building cars since 1899.
Opel Ascona
The Opel Ascona is a mid-size car built by Opel in three generations from 1970 to 1988, winning the 1982 World Rally Championship drivers' title with Walter Röhrl.
Opel Astra
The Opel Astra is a compact car built by German manufacturer Opel since 1991, when it replaced the Kadett, and sold in the UK as the Vauxhall Astra.
Opel Calibra
The Opel Calibra, sold in Britain as the Vauxhall Calibra, is a German sports coupé built from 1990 to 1997 and the best-selling sports coupé of the 1990s.
Opel Corsa
The Opel Corsa, sold as the Vauxhall Corsa in the UK, is a small hatchback built by Opel since 1982, with six generations and over 14.5 million units.
Opel Frontera (2024)
The Opel Frontera, sold as the Vauxhall Frontera in the UK, is a compact crossover SUV built by Stellantis and revealed on 14 May 2024.
Opel GSE Formula E Team
Opel GSE Formula E Team: Opel's works Formula E team (Stellantis brand), racing from Season 13, 2026/27, GEN4 era, on a four-year contract; drivers Mitch Evans and Théo Pourchaire, car GSE 27FE.