All articles starting with S

Splenic lymph nodes

Splenic lymph nodes (nodi splenici) lie at the splenic hilum, drain the spleen, pancreas body/tail, and stomach, and form gastric cancer station 10; key regional nodes in pancreatic and gastric cancer surgery.

Oct 20, 2026

Splenic macrophage

Splenic macrophages are the spleen's tissue-resident macrophage subsets: red pulp, marginal zone, metallophilic, and tingible body macrophages, which clear aged erythrocytes, recycle iron, filter blood-borne pathogens, and shape adaptive immunity.

Splenic marginal zone lymphoma

Splenic marginal zone lymphoma (SMZL) is a rare indolent B-cell non-Hodgkin lymphoma of the spleen, bone marrow, and blood, marked by 7q deletion, NOTCH2 and KLF2 mutations, and rituximab or splenectomy treatment.

Splenic sequestration crisis

Splenic sequestration crisis, also called acute splenic sequestration, is a sickle cell disease emergency in which red cells trap in the spleen, dropping hemoglobin by 2 g/dL or more; treated with transfusion, sometimes splenectomy.

Splenic vein

Splenic vein: large abdominal vein formed at the splenic hilum, draining spleen, pancreas, and stomach; joins the superior mesenteric vein behind the pancreatic neck to form the portal vein; key diseases are splenic vein thrombosis and left-sided portal hypertension.

Splenocyte

Splenocyte (Cell Ontology CL:2000074): any leukocyte that is part of the spleen; a vague umbrella term for splenic T cells, B cells, macrophages, and dendritic cells used in isolation and immune assays.

Splenomegaly

Splenomegaly, an enlarged spleen (over 12 cm length or 400 g), arises from portal hypertension, infections like EBV and malaria, infiltration, or hematopoiesis; massive splenomegaly exceeds 20 cm or 1000 g and risks rupture.

Splenorenal shunt

A splenorenal shunt is a surgical operation connecting the splenic vein to the left renal vein, lowering portal pressure to control variceal bleeding; the selective distal form dates to 1967.

Splenosis

Splenosis, also called splenic autotransplantation, is benign ectopic splenic tissue implanted after splenic trauma or splenectomy; diagnosed by Tc-99m heat-damaged RBC scintigraphy, it mimics malignancy and occurs in up to 65% of splenic ruptures.

Splice (film)

Splice (Nouvelle espèce) is a 2009 sci-fi horror film by Vincenzo Natali starring Adrien Brody, Sarah Polley, and Delphine Chanéac as Dren, a human-animal hybrid; Sundance premiere 2010, Warner Bros. release, 75% on Rotten Tomatoes.

Splice Bio

SpliceBio is a clinical-stage Barcelona genetic medicines company founded in 2020, whose lead candidate SB-007, a dual AAV gene therapy for Stargardt disease, entered clinical trials in 2025.

Splice site mutation

Splice site mutation: a DNA change disrupting spliceosome recognition of exon-intron boundaries (GT donor, AG acceptor dinucleotides), causing exon skipping, intron retention, or cryptic site use; a major cause of genetic disease, targetable by splice-switching antisense oligonucleotides.

Splice site prediction

Splice site prediction is the computational identification of splice donor and acceptor sites in DNA or RNA, using machine-learning models to support gene annotation and variant interpretation.

Splice the mainbrace

Splice the mainbrace: naval order for a celebratory issue of rum, from repairing a square-rigged ship's largest rigging; ordered only by royalty or Admiralty, retained after the 1970 rum-ration abolition.

Splice-site recognition and consensus sequences

Splice-site recognition is how the spliceosome locates the short motifs marking where an intron begins and ends; in mammals, consensus sequences are too loose to specify splicing alone.

SpliceBio

SpliceBio is a clinical-stage genetic medicines company in Barcelona, founded in 2020, whose dual AAV protein splicing platform backs SB-007, a gene therapy for Stargardt disease now in Phase 1/2 trials.

Spliceosome

Spliceosome: nuclear RNA-protein machine (U1, U2, U4, U5, U6 snRNPs plus ~150 proteins) that removes introns from pre-mRNA via two transesterifications; a parallel minor spliceosome (U11, U12, U4atac, U6atac, shared U5) splices ~0.5% of introns.

Spliceosome assembly pathway

The spliceosome assembly pathway is the ordered sequence of complexes through which the spliceosome forms on pre-mRNA, spanning at least 10 states from E to the intron-lariat spliceosome.

Splicing analysis methods and resources

Splicing analysis methods and resources are the computational tools for detecting and quantifying alternative splicing in RNA-seq, spanning event-level callers like rMATS and long-read isoform tools like IsoQuant.

Splicing factor U2AF

U2AF (U2AF65/U2AF35 heterodimer, U2AF2/U2AF1) is the essential splicing factor that binds the polypyrimidine tract and 3' splice site AG to define 3' splice sites and recruit U2 snRNP.

SPLID trial

SPLID (NCT05041829) is a pilot single-center crossover single-blind randomized controlled trial at UC Irvine testing low versus high dietary sodium intake for blood pressure, kidney function, and proteinuria in living kidney donors 5-12 months post-donation; currently suspended.

Sep 19, 2026

Spliff

Spliff was a German rock band from West Berlin, formed around 1980 from the Nina Hagen Band, best known for the 1982 album 85555 and its hit single "Carbonara".

Spline (mathematics)

A spline, also called a spline curve or spline function, is a piecewise polynomial function whose pieces join smoothly at breakpoints, used to interpolate data.

Spline interpolation

Spline interpolation, or interpolating spline, fits a low-degree piecewise polynomial, usually cubic, through data points with smooth joins at the knots, avoiding the wild oscillations of single high-degree polynomials; I. J. Schoenberg introduced it in 1946.

Spline regression

Spline regression fits piecewise polynomials, typically cubic, constrained to join smoothly at knots to model nonlinear relationships; variants include smoothing splines, P-splines, natural splines, and Friedman's MARS.

Spline+

Spline+ is a 2011 two-player abstract ball-stacking game by Néstor Romeral Andrés, an extension of Spline in the Shibumi system; players place or move marbles on a 4×4 board to form a winning line on any pyramid level.

Splint (medicine)

Splint (medicine): noncircumferential plaster, fiberglass, or thermoplastic appliance immobilizing an injury across the joints above and below it. Distinguished from circumferential casts and prefabricated braces; used for fractures, sprains, and tendon injuries.

Splint therapy

Splint therapy is a dental treatment in which a custom-made removable appliance worn over the teeth treats jaw joint disorders and teeth grinding, protecting them from clenching damage.

Splinter (2008 film)

Splinter (2008) is an American horror film, Toby Wilkins's feature debut, starring Shea Whigham, Jill Wagner, and Paulo Costanzo. Parasite creature feature set at an Oklahoma gas station; 82 minutes, Magnet Releasing, six Screamfest 2008 awards, $522,497 worldwide gross.