All articles starting with S
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Serpico
Serpico (1973) is Sidney Lumet's biographical crime drama starring Al Pacino as NYPD whistleblower Frank Serpico, adapted from Peter Maas's book; it earned two Oscar nominations, won Pacino a Golden Globe, and was shot entirely on New York City locations.
Serpiginous choroiditis
Serpiginous choroiditis, also called geographic or helicoid peripapillary choroidopathy, is a rare chronic bilateral posterior uveitis of the choroid, RPE, and choriocapillaris, distinguished from tubercular multifocal serpiginoid choroiditis by imaging and TB testing.
Serpil Erzurum
Serpil C. Erzurum is an American pulmonologist-scientist and Cleveland Clinic's Chief Research and Academic Officer, elected to the National Academy of Medicine in 2017 for asthma research.
Serpin family
Serpin family (SERPIN superfamily, serine protease inhibitors): largest protease inhibitor superfamily, 1,500+ members across all kingdoms, 36 human genes in clades A–P; suicide inhibition via RCL-to-β-sheet-A conformational change; mutations cause serpinopathies like emphysema and thrombosis.
SERPINA3
SERPINA3, also called alpha-1-antichymotrypsin (AACT, ACT), is a human serpin gene at 14q32.13 encoding a 46 kDa acute-phase serine protease inhibitor made mainly by the liver, linked to Alzheimer's disease, heart failure, and several cancers.
SERPINB4
SERPINB4 (SCCA2, leupin, PI11) is a human protein-coding gene at 18q21.33 encoding a 390-amino-acid clade B serpin that inhibits cathepsin G, chymase, and granzyme M; highly expressed in squamous epithelia and tumors, and with SERPINB3 a source of psoriasis autoantigen.
SERPINB5
SERPINB5 (maspin, PI5), a non-inhibitory clade B serpin gene at 18q21.3 identified in 1994; knockout mice develop normally, and the protein shows context-dependent pro- and anti-tumor roles across cancers.
SERPINC1
SERPINC1 (serpin family C member 1, HGNC:775, OMIM 107300) is a human gene at 1q25.1 encoding antithrombin III, the principal plasma anticoagulant; pathogenic variants cause autosomal dominant hereditary antithrombin deficiency, a high-risk thrombophilia.
SERPINE2
SERPINE2 (glia-derived nexin, PN1, GDN), human gene at 2q36.1 encoding a serpin that inhibits thrombin, urokinase, plasmin, and trypsin; COPD and emphysema susceptibility gene, placenta-enriched, implicated in Alzheimer's disease, asthma, and cancers.
SERPINF1
SERPINF1 (serpin family F member 1, PEDF) is a human gene on 17p13.3 encoding a 50-kDa non-inhibitory serpin that inhibits angiogenesis, supports bone mineralization, and causes osteogenesis imperfecta type VI when biallelically mutated.
SERPINH1
SERPINH1 encodes HSP47 (Serpin H1, formerly colligin or gp46), a 47-kDa ER-resident collagen-specific molecular chaperone with a serpin fold but no protease-inhibitory activity; essential for procollagen triple-helix folding, its mutations cause osteogenesis imperfecta type X.
Serplulimab
Serplulimab (HLX10; Hansizhuang, Hetronifly) is a humanized IgG4 anti-PD-1 monoclonal antibody by Shanghai Henlius, first approved in China in 2022 for MSI-H solid tumors and known for the ASTRUM-005 ES-SCLC survival benefit.
Serpula
Serpula is a genus of serpulid calcareous tubeworms (Polychaeta, Serpulidae); type species Serpula vermicularis builds calcareous tubes 4–5 mm wide and rare reef aggregations in Scottish and Irish sea lochs such as Loch Creran.
Serpulidae
Serpulidae, commonly known as calcareous tubeworms, is a family of sessile polychaete worms that live permanently in calcium carbonate tubes, sealed by an operculum in most species.
Serra da Capivara National Park
Serra da Capivara National Park (Parque Nacional da Serra da Capivara), Piauí, Brazil: 1979 national park, UNESCO World Heritage Site since 1991, with over 1,000 archaeological sites, rock art, and the disputed Pedra Furada pre-Clovis dates.
Serra da Estrela
Serra da Estrela, or Estrela Mountains, is a granite mountain range in east-central Portugal whose Torre summit, at 1,993 m, is the highest point in mainland Portugal.
Serra da Ibiapaba
Serra da Ibiapaba (Serra Grande) is a ~380 km cuesta plateau on the Ceará–Piauí border in northeastern Brazil, with a humid forested east face above 1,100 mm rainfall, the 1.6-million-hectare APA created in 1996, and the 164 km Caminhos da Ibiapaba trail.
Serra da Mesa hydroelectric plant
The Serra da Mesa hydroelectric plant (Usina Hidrelétrica de Serra da Mesa) is a 1,275 MW station on the Tocantins River in Goiás, Brazil, operating since 1998.
Serra de Curupira
Serra de Curupira (Sierra Curupira) is a mountain range on the Brazil–Venezuela border in the northern Amazon, part of the Guiana Highlands; it feeds the Içana River and includes heights near 2,105–2,349 m.
Serra do Barbado
Serra do Barbado, a mountain range in southeastern Chapada Diamantina, Bahia, Brazil; contains Pico do Barbado (2,033 m), the highest point of Bahia and the Brazilian Northeast, within the APA da Serra do Barbado.
Serra do Cachimbo
Serra do Cachimbo, a 550-km SE-NW sandstone range between Mato Grosso and Pará, Brazil, in the Amazon-Cerrado transition; hosts the Campo de Provas Brigadeiro Velloso air force testing ground and the 342,192-ha Nascentes da Serra do Cachimbo Biological Reserve (2005).
Serra do Espinho
Serra do Espinho: name of several Brazilian uplands, chiefly a ridge on the eastern slope of the Borborema Plateau between Pilões and Cuitegi, Paraíba, crossed by PB-077; also a 541 m ridge in Minas Gerais and a 543 m hill in Paulista, Paraíba.
Serra dos Gradaús
Serra dos Gradaús (also Serra dos Gradahús) is a 469 m upland ridge in Santana do Araguaia, Pará, Brazil, and the name of a 1882±9 Ma anorogenic granite batholith of the Carajás Province, Amazonian Craton.
Serra Dourada
Serra Dourada, Goiás, Brazil: ENE-trending quartzite hogback and Paraná–Araguaia drainage divide; Parque Estadual da Serra Dourada (2003, ~30,000 ha) and APA (1998, 37,041 ha); distinct from Bahia municipality.
Serra East
Serra East is a multi-period archaeological site on the east bank of the Nile in northern Sudan, anchored by a Middle Kingdom Egyptian fortress built under Senuseret III at the Second Cataract.
Serra Geral
Serra Geral, southern Brazil's basalt-capped escarpment along the Paraná Plateau, formed by Cretaceous Paraná-Etendeka flood basalts about 130 Ma, distinct from the crystalline Serra do Mar; includes Serra Geral National Park and Fortaleza Canyon.
Serra Imeri
Serra Imeri (Serra do Imeri), a mountain range on the Brazil–Venezuela border in Amazonas, holds Brazil's two highest peaks, Pico da Neblina (2,995.3 m) and Pico 31 de Março, and marks part of the international boundary.
Serra Tulu Tuloi
Serra Tulu Tuloi (Serra Tulu-Tuloi) is an ultra-prominent mountain range in Barcelos, Amazonas, Brazil, in the Southern Guiana Highlands; summit about 2,136-2,140 m, prominence about 1,950-1,967 m, near Tulu Tuloi II and the Serra do Aracá tepui complex.
Serra, Espírito Santo
Serra, Espírito Santo, Brazil's most populous municipality in that state (520,653 in 2022), part of Greater Vitória; founded 1556, municipality 1833; largest state economy, Porto de Tubarão, Mestre Álvaro, congo folklore.
Serrambi
Serrambi is a beach district in Ipojuca, Pernambuco, Brazil, near Porto de Galinhas, with reef-protected natural pools, the APA Marinha Recifes Serrambi marine protected area, and the PADI Five Star Serrambi Resort.