All articles starting with S

SIRT1

SIRT1 (sirtuin 1) is a human NAD+-dependent protein deacetylase, homolog of yeast Sir2, regulating p53, FOXO, PGC-1α, and NF-κB in metabolism, inflammation, and DNA repair; resveratrol and Sirtris compounds are not direct activators.

SIRT2

SIRT2 (sirtuin 2) is a human NAD+-dependent cytoplasmic lysine deacylase of the sirtuin family, acting on alpha-tubulin, H4K16, and Rheb, with demyristoylase activity, dual roles in cancer and neurodegeneration, and inhibitors such as AGK2 and TM.

SIRT3

SIRT3 (sirtuin 3, SIR2L3) is a human NAD+-dependent mitochondrial deacetylase on chromosome 11p15.5, the primary mitochondrial sirtuin, regulating metabolism, ROS defense, heart disease, cancer, and aging.

SIRT5

SIRT5 (sirtuin 5) is a predominantly mitochondrial NAD+-dependent lysine deacylase that removes succinyl, malonyl, glutaryl, and acetyl groups, regulating metabolism, CPS1-mediated ammonia detoxification, ROS defense, and context-dependent cancer roles.

SIRT6

SIRT6 (sirtuin 6, SIR2L6) is a nuclear NAD+-dependent human deacylase at 19p13.3 regulating DNA repair, telomeres, metabolism, inflammation, and aging; its overexpression extends mouse lifespan and modulators like IMU-856 are in trials.

Oct 20, 2026

SIRT7

SIRT7 (sirtuin 7, SIR2L7), human gene at 17q25.3, encodes a 400 amino acid nucleolar NAD+-dependent deacetylase/desuccinylase, the least-studied sirtuin, regulating ribosome biogenesis, H3K18ac, genome stability, metabolism, aging, and cancer.

Sirtuin

Sirtuins (SIRT1–SIRT7), homologs of yeast Sir2, are NAD+-dependent protein deacylases regulating metabolism, chromatin, DNA repair, and inflammation; their role as longevity genes is contested.

Sirukduh

Sirukduh, also spelled Siruk-tuh, was a sukkalmah of Elam in the early 18th century BC, when Elam acted as powerbroker among Assyria, Babylonia, Eshnunna, and Mari.

Sirukumab

Sirukumab (CNTO 136) is a fully human IgG1κ monoclonal antibody against interleukin-6 developed by Janssen for rheumatoid arthritis; effective in SIRROUND trials but never marketed after FDA and EMA rejections in 2017 over long-term safety.

SIRUP

SIRUP (シラップ) is a Japanese R&B singer-songwriter project from Osaka Prefecture, created by the artist formerly known as KYOtaro and debuted in September 2017 with "Synapse".

Oct 22, 2026

Sirupanarruppatai

Sirupanarruppatai (சிறுபாணாற்றுப்படை) is a classical Tamil Sangam poem, the third of the ten Pattuppattu idylls, in which poet Nathathanar directs a wandering bard to the patron Oyman Nalliyakodan.

Sirusho

Sirusho (Սիրուշո), born Siranush Harutyunyan in 1987 in Yerevan, is an Armenian pop singer and songwriter best known for finishing fourth at Eurovision 2008 with "Qele, Qele".

Siruthai

Siruthai (சிறுத்தை) is a 2011 Tamil action comedy directed by Siva, a remake of Rajamouli's Telugu hit Vikramarkudu, starring Karthi in a dual role as thief Rocket Raja and cop Ratnavel Pandian with Tamannaah and Santhanam; a Pongal 2011 box-office hit.

Sep 23, 2026

Siruthondar

Siruthondar (சிருத்தொண்டர்), born Paranjothi, was a Pallava commander under Narasimhavarman I who captured Vatapi in 642 and was later revered as one of the 63 Saiva Nayanar saints.

Oct 22, 2026

Sirventes

The sirventes was a satirical, moral, or political song genre of the troubadours of southern France, flourishing in the 12th and 13th centuries as an alternative to the courtly love song.

Sirwah

Sirwah (Ṣirwāḥ) is an ancient walled city of the kingdom of Saba in the Khawlān highlands of Yemen, about 40 km west of Marib, known for its Almaqah temple and royal inscriptions.

Siryn

Siryn (Theresa Maeve Rourke Cassidy) is a Marvel Comics mutant, daughter of Banshee, with a sonic scream up to 140 dB, flight, and sonic hypnosis; debuted in Spider-Woman #37 (1981), later X-Force member and X-Factor's Morrigan.

SIS (Soft Is Strong)

SIS (Soft Is Strong) is the debut EP of global girl group KATSEYE, released August 16, 2024 by HYBE x Geffen; five tracks about 11 minutes long, preceded by singles Debut and Touch, peaking at number 119 on the Billboard 200.

SIS Building

SIS Building, aka MI6 Building or Vauxhall Cross, at 85 Albert Embankment, London: Terry Farrell's 1994 postmodern ziggurat headquarters of Britain's Secret Intelligence Service, built by Regalian and featured in James Bond films.

Sep 29, 2026

SIS model

The SIS model is a compartmental epidemic model where individuals move from susceptible to infected and back to susceptible on recovery, with no lasting immunity; it suits gonorrhea and computer viruses.

SIS trial

SIS trial: NCT04599127, a completed Mahidol University randomized trial of Mulligan mobilization with movement added to conventional physical therapy in shoulder impingement syndrome; 22 participants in Jakarta, no results posted.