All articles starting with T
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Triethylsilane
Triethylsilane is an organosilicon compound with the formula (C2H5)3SiH, a colorless liquid used chiefly as a hydride-donating reducing agent in organic synthesis, typically with Brønsted or Lewis acids.
Triethylsilyl protecting group
The triethylsilyl (TES) group is a silyl protecting group for alcohols, installed with TES chloride and imidazole and removed under milder conditions than TBS, enabling selective deprotection.
Trieu Viet Vuong
Trieu Viet Vuong, personal name Triệu Quang Phục, ruled the Viet state of Van Xuan from 548 to 571, waging guerrilla war against the Chinese Liang dynasty.
Trifarotene
Trifarotene (Aklief) is a fourth-generation topical retinoid, a selective RAR-γ agonist approved by the FDA in October 2019 as a 0.005% once-daily cream for facial and truncal acne vulgaris in patients 9 years and older.
Trifenmorph
Trifenmorph (4-tritylmorpholine, CAS 1420-06-0), obsolete Shell molluscicide used against schistosomiasis snail vectors; selective snail neurotoxin raising intracellular chloride; not EU-approved, no longer made in the USA.
Triflate
Triflate, or trifluoromethanesulfonate, is the CF₃SO₃⁻ anion, conjugate base of triflic acid, whose esters serve as outstanding leaving groups and whose aryl and vinyl forms are standard partners in cross-coupling reactions.
Trifle
Trifle, or Punschtorte, is a British dessert of sponge cake and fruit. Its earliest known recipe appeared in 1596, and it is traditionally served in a glass bowl.
Trifloxystrobin
Trifloxystrobin (Flint) is a strobilurin (QoI, FRAC 11) agricultural fungicide discovered by Novartis, announced 1998, sold to Bayer in 2000; it blocks mitochondrial complex III respiration and is EU-approved since 2003.
Trifloxysulfuron
Trifloxysulfuron (CGA 362622, CGA 292230) is a Syngenta sulfonylurea, ALS-inhibiting post-emergence herbicide used as the sodium salt in cotton, sugarcane, citrus, and turf at gram-per-hectare rates; not EU-approved, with documented Poa annua resistance.
Triflumezopyrim
Triflumezopyrim (DPX-RAB55) is the first mesoionic insecticide, IRAC Group 4E, developed by DuPont and registered in 2016. It inhibits the orthosteric site of insect nicotinic acetylcholine receptors, controlling neonicotinoid-resistant rice planthoppers with low resistance risk and safety to natural enemies.
Triflumizole
Triflumizole is an imidazole fungicide, sold as Procure and Terraguard, that controls powdery mildew and scab on fruit, vegetable, and ornamental crops by blocking ergosterol biosynthesis.
Triflumuron
Triflumuron (SIR 8514, Alsystin, Zapp) is a Bayer-discovered benzoylurea insecticide, IRAC group 15 chitin synthesis inhibitor acting on CHS1, used on crops and sheep lice; EU-banned since 2023.
Trifluoperazine
Trifluoperazine is a typical antipsychotic of the piperazine phenothiazine class, first launched as Stelazine by Smith Kline & French in 1958, used mainly for schizophrenia and psychoses and at low doses for anxiety and nausea.
Trifluoroacetamide
Trifluoroacetamide (2,2,2-trifluoroacetamide, CF₃CONH₂) is the amide of trifluoroacetic acid, a white crystalline solid used as a pharmaceutical intermediate, a protecting-group precursor, and a perovskite solar cell additive.
Trifluoroacetate
Trifluoroacetate is the conjugate base of trifluoroacetic acid, an extremely persistent PFAS with no known degradation pathway, formed largely from HCFC, HFC, and HFO refrigerant breakdown.
Trifluoroacetic acid
Trifluoroacetic acid (TFA, CF3COOH) is a strongly acidic fluorinated carboxylic acid used as a reagent in organic synthesis and peptide manufacture, increasingly scrutinized as a persistent, rising environmental contaminant.
Trifluoroacetic anhydride
Trifluoroacetic anhydride (TFAA) is the acid anhydride of trifluoroacetic acid, with the formula (CF₃CO)₂O, a colorless, strongly fuming liquid used as a trifluoroacetylating and dehydrating agent and as a derivatization reagent for gas chromatography.
Trifluoromethanesulfonic acid
Trifluoromethanesulfonic acid (CF₃SO₃H), commonly called triflic acid, is a superacid far stronger than sulfuric acid, first reported in 1954 and a standard reagent in organic synthesis.
Trifluoromethoxylation
Trifluoromethoxylation is the introduction of the trifluoromethoxy group (–OCF₃) into an organic molecule, producing trifluoromethyl ethers valued in pharmaceuticals, agrochemicals, and materials for their stability.
Trifluoromethylation
Trifluoromethylation is a chemical reaction that introduces a trifluoromethyl (CF3) group into organic molecules, replacing hydrogen or halogen; 15 of the top 200 drugs of 2018 contain the group.
Trifluoromethylation of arylboronic acids
Trifluoromethylation of arylboronic acids is a family of reactions converting Ar–B(OH)2 into trifluoromethylated arenes, typically with copper and a CF3 source, first reported in 2010 and 2011.
Trifluoromethylthio compounds
Trifluoromethylthio compounds are organic sulfides bearing the SCF3 group, whose strong lipophilicity and metabolic stability make it valuable in marketed drugs and the insecticide Fipronil.
Trifluoromethylthiolation
Trifluoromethylthiolation is a chemical reaction that installs the trifluoromethylthio group (SCF3) onto organic molecules, valued in drug discovery for combining strong electron withdrawal with high lipophilicity.
Trifluperidol
Trifluperidol (R-2498, Triperidol) is a butyrophenone antipsychotic and dopamine antagonist similar to haloperidol, synthesized 1959 by Janssen, used for psychoses including schizophrenia and mania; not FDA-approved, mainly available in India.
Triflupromazine
Triflupromazine (Vesprin, Siquil, fluopromazine) is a phenothiazine dopamine D1/D2 antagonist antipsychotic and antiemetic, FDA-approved 1957, discontinued for humans but still a veterinary tranquilizer for dogs, cats, and horses.
Trifluralin
Trifluralin, sold as Treflan, is a selective pre-emergence dinitroaniline herbicide used to control annual grasses and broadleaf weeds in agricultural crops, first registered in the United States in 1963.
Trifluridine
Trifluridine, also known as trifluorothymidine or TFT, is a fluorinated antiviral drug used as 1% eye drops for herpes simplex keratitis and in Lonsurf for colorectal cancer.
Triflusal
Triflusal, marketed as Disgren, is an oral antiplatelet drug related to the salicylates, used to prevent recurrent stroke and myocardial infarction in Europe and South Korea.
Triflusulfuron
Triflusulfuron (triflusulfuron-methyl, DPX-66037, UpBeet, Debut) is a triazinylsulfonylurea ALS-inhibiting herbicide for weeds in sugar beet; EU approval expired November 2023.
Trifoliate orange (枳)
Trifoliate orange (枳, karatachi), Citrus trifoliata, formerly Poncirus trifoliata, is a deciduous thorny Chinese citrus relative, the hardiest citrus, used worldwide as a cold-hardy, disease-tolerant semi-dwarfing rootstock and in citrus hybrid breeding.