All articles starting with T

Thromboblast

Thromboblast (thromboblasts), ZFA:0009351, is the progenitor cell of the thrombocyte, the nucleated coagulation cell of birds, reptiles, amphibians, and fish, the non-mammalian counterpart of the mammalian megakaryocyte-platelet system.

Thrombocythemia

Thrombocythemia, especially essential thrombocythemia (ET), is a chronic myeloproliferative neoplasm causing platelet counts above 450 x 10^9/L, driven by JAK2, CALR, or MPL mutations, with thrombosis risk managed by aspirin and hydroxyurea.

Thrombocytopenia

Thrombocytopenia, a low blood platelet count below the normal 140–440 × 10^9/L range, causes petechiae and mucosal bleeding; causes include ITP, drugs, infection, sequestration, and marrow failure, with transfusion thresholds of 10–50 × 10^9/L.

Thrombocytopenia with congenital dyserythropoietic anemia

Thrombocytopenia with congenital dyserythropoietic anemia (XDAT, XLTDA, ORPHA:67044, OMIM 300367) is a rare X-linked recessive GATA1-related blood disorder of males causing macrothrombocytopenia, bleeding, and variable anemia from infancy.

Thrombocytopenia-absent radius syndrome

Thrombocytopenia-absent radius (TAR) syndrome, radial aplasia-thrombocytopenia syndrome, a rare autosomal recessive disorder from compound RBM8A null and hypomorphic alleles, causing absent radii with present thumbs and transient infantile thrombocytopenia.

Thrombocytosis

Thrombocytosis is an elevated platelet count above 450 × 10⁹/L, most often reactive to infection, inflammation, or iron deficiency, but sometimes a clonal disorder such as essential thrombocythemia.

Thromboelastography

Thromboelastography (TEG), invented by Hellmut Hartert in Germany in 1948, is a viscoelastic whole-blood point-of-care coagulation test measuring R, K, alpha-angle, MA, and LY30 to guide transfusion in cardiac surgery, liver transplantation, and trauma.

Thromboelastometry

Thromboelastometry is a point-of-care viscoelastic test that measures clot formation and strength in whole blood, guiding transfusion and anticoagulant therapy in trauma, cardiac surgery, and obstetric bleeding.

Thromboembolism

Thromboembolism, chiefly venous thromboembolism (VTE), combines deep vein thrombosis and pulmonary embolism. Key facts: Virchow's triad, duplex ultrasound and CTPA diagnosis, anticoagulant and DOAC treatment, prevention after surgery.

Thromboendarterectomy

Thromboendarterectomy is a surgical procedure removing obstructive material, such as thrombus or plaque, from an artery along with its diseased inner wall layers, chiefly for stroke prevention and pulmonary hypertension.

Thrombolysis

Thrombolysis is the pharmacological dissolution of blood clots by drugs that convert plasminogen to plasmin, used for acute ischemic stroke within 4.5 hours and pulmonary embolism.

Thrombolysis for acute ischemic stroke

Thrombolysis for acute ischemic stroke: intravenous alteplase (tPA, Activase) or tenecteplase given within 4.5 hours of onset, FDA-approved 1996 after the NINDS trial, with extended imaging-selected windows and hemorrhage as the main risk.

Thrombolytic therapy

Thrombolytic therapy is treatment with clot-dissolving drugs such as alteplase and tenecteplase, given intravenously to break up clots in stroke, heart attack, and pulmonary embolism.

Thrombophilia

Thrombophilia, also known as a hypercoagulable state, is a condition in which the blood has an increased tendency to clot, raising the risk of venous thromboembolism.

Thrombophilia testing

Thrombophilia testing is the laboratory workup identifying inherited or acquired tendencies to venous thromboembolism, testing factor V Leiden, antithrombin, protein C and S, and antiphospholipid antibodies.

Thrombophlebitis

Thrombophlebitis, also called phlebitis or superficial vein thrombosis, is vein inflammation caused by a blood clot, usually in leg veins near the skin; distinguished from deep vein thrombosis by ultrasound and treated with heat, NSAIDs, or anticoagulants.

Thrombophlebitis migrans

Thrombophlebitis migrans, or migratory thrombophlebitis, is recurrent thrombosis of vein segments at shifting sites; when unexplained it is Trousseau syndrome, a paraneoplastic sign of occult cancer, especially pancreatic, gastric, and lung adenocarcinoma.

Thrombosis

Thrombosis, from Greek thrombos, is blood clot formation inside a vessel, explained by Virchow's triad of stasis, endothelial injury, and hypercoagulability; arterial clots cause heart attack and stroke, venous clots cause DVT and pulmonary embolism, treated with anticoagulants from heparin to DOACs.

Thrombosis and haemostasis

Thrombosis and haemostasis: paired medical field covering clot formation (thrombosis) and bleeding control (hemostasis), and the 1957-founded Thieme journal of the same name tied to the ISTH.

Thrombosis prevention

Thrombosis prevention (thromboprophylaxis) uses anticoagulants such as LMWH and DOACs, compression devices, and early mobilization to prevent DVT and pulmonary embolism in surgical, medical, pregnant, and high-risk travel populations.

Thrombosis Research

Thrombosis Research is an Elsevier peer-reviewed journal (ISSN 0049-3848) covering thrombosis, hemostasis, and vascular biology since 1972; Scopus Q1 hematology, CiteScore 5.8, Impact Factor 3.4, companion title Thrombosis Update.

Thrombospondin-like, N-terminal domain

Thrombospondin-like, N-terminal domain: the amino-terminal module of thrombospondins, including the heparin binding domain (HBD) and laminin G-like N-terminal domain, binding heparan sulfate proteoglycans, LRP, calreticulin, and integrins.

Thrombotic thrombocytopenic purpura

Thrombotic thrombocytopenic purpura (TTP, Moschcowitz disease) is a rare blood disorder from severe ADAMTS13 deficiency, congenital or autoimmune, causing microvascular clots; treated with plasma exchange, rituximab, caplacizumab, or recombinant ADAMTS13.

Oct 15, 2026

Thromboxane

Thromboxane is an eicosanoid with a six-membered oxygen-containing ring, formed from prostaglandin endoperoxides and best known for causing platelet aggregation and contraction of arteries.

Oct 15, 2026

Thromboxane A2

Thromboxane A2 (TXA2) is a chemically unstable prostanoid lipid, identified in 1975, that is produced by activated platelets to promote clotting and constricts vascular and bronchial smooth muscle.

Oct 15, 2026

Thromboxane B2

Thromboxane B2 (TXB2) is the stable, biologically inactive hydrolysis product of thromboxane A2, an unstable platelet eicosanoid, and serum TXB2 is widely used to assess aspirin's inhibition of platelet COX-1.

Thromboxane receptor

Thromboxane receptor (TP, TBXA2R), a GPCR on platelets and vascular cells binding TXA2, PGH2, and isoprostanes; couples Gq/G12-13, drives aggregation, and its loss causes bleeding disorder BDPLT13.

Thrombus

Thrombus (plural thrombi): a blood clot forming inside a vein, artery, or heart; if it breaks loose it becomes an embolus. Framed by Virchow's triad of hypercoagulability, stasis, and endothelial injury; causes DVT, pulmonary embolism, ischemia, and stroke.

Throne

Throne: ceremonial chair of a monarch, prelate, or high dignitary, from Greek thronos; placed on a dais under a canopy, used in enthronement rites, and distinct from the British Coronation Chair.