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Sironax (维泰瑞隆)
Sironax (维泰瑞隆) is a clinical-stage biopharmaceutical company founded in 2017 by Wang Xiaodong and Zhang Zhiyuan that develops drugs targeting aging-related degenerative, metabolic, and inflammatory diseases.
SIRPA
SIRPA, also known as CD172a, is a human gene on chromosome 20 encoding SIRPα, a receptor that transmits the "don't eat me" signal preventing phagocytosis of healthy cells.
Sirpa Jalkanen
Sirpa Jalkanen, born 1954, is a Finnish immunologist at the University of Turku whose research established how immune cells enter inflamed tissue; she identified VAP-1 and was named Academician of Science in 2015.
Sirpur Mound
Sirpur Mound (Shripura/Sripura) is an archaeological site in Mahasamund district, Chhattisgarh, India, on the Mahanadi River; capital of Dakshina Kosala, 5th–12th century CE, with the brick Lakshmana Temple, Hindu, Buddhist and Jain remains, and a 2026 UNESCO Tentative List nomination.
Sirri C Oil Field
Sirri C Oil Field, also known as Sirri Civand, is an offshore oil field in the Persian Gulf southwest of Sirri Island, Iran, producing since 1978.
Sirrin Biosphere Reserve
Sirrin Biosphere Reserve, also written Al-Sareen, is a UNESCO biosphere reserve in Oman's Eastern Hajar Mountains, nominated in 2025 to protect the endangered Arabian tahr.
Sirsa Mound
Sirsa Mound (Ther Mound, locally Thehad), ancient settlement mound in Sirsa, Haryana; ASI-protected since 1932, 85.5 acres, occupied circa 6th-5th century BC to 12th century AD, never excavated.
Sirsa, Haryana
Sirsa (सिरसा) is a city in Haryana, India, headquarters of the state's westernmost and largest district (4,276 km²). Ancient Sairishaka/Sarsuti on the Ghaggar; refounded 1837; district re-formed 1975; cotton and kinnow belt.
Sirsukh
Sirsukh, the third Kushan-era city of Taxila in Pakistan, built north of Sirkap in the 1st century CE; a walled rectangle of about 1372 by 920 m, largely unexcavated, part of the UNESCO Taxila site.
SIRT1
SIRT1 (sirtuin 1) is a human NAD+-dependent protein deacetylase, homolog of yeast Sir2, regulating p53, FOXO, PGC-1α, and NF-κB in metabolism, inflammation, and DNA repair; resveratrol and Sirtris compounds are not direct activators.
SIRT2
SIRT2 (sirtuin 2) is a human NAD+-dependent cytoplasmic lysine deacylase of the sirtuin family, acting on alpha-tubulin, H4K16, and Rheb, with demyristoylase activity, dual roles in cancer and neurodegeneration, and inhibitors such as AGK2 and TM.
SIRT3
SIRT3 (sirtuin 3, SIR2L3) is a human NAD+-dependent mitochondrial deacetylase on chromosome 11p15.5, the primary mitochondrial sirtuin, regulating metabolism, ROS defense, heart disease, cancer, and aging.
SIRT5
SIRT5 (sirtuin 5) is a predominantly mitochondrial NAD+-dependent lysine deacylase that removes succinyl, malonyl, glutaryl, and acetyl groups, regulating metabolism, CPS1-mediated ammonia detoxification, ROS defense, and context-dependent cancer roles.
SIRT6
SIRT6 (sirtuin 6, SIR2L6) is a nuclear NAD+-dependent human deacylase at 19p13.3 regulating DNA repair, telomeres, metabolism, inflammation, and aging; its overexpression extends mouse lifespan and modulators like IMU-856 are in trials.
SIRT7
SIRT7 (sirtuin 7, SIR2L7), human gene at 17q25.3, encodes a 400 amino acid nucleolar NAD+-dependent deacetylase/desuccinylase, the least-studied sirtuin, regulating ribosome biogenesis, H3K18ac, genome stability, metabolism, aging, and cancer.
Sirtuin
Sirtuins (SIRT1–SIRT7), homologs of yeast Sir2, are NAD+-dependent protein deacylases regulating metabolism, chromatin, DNA repair, and inflammation; their role as longevity genes is contested.
Sirukduh
Sirukduh, also spelled Siruk-tuh, was a sukkalmah of Elam in the early 18th century BC, when Elam acted as powerbroker among Assyria, Babylonia, Eshnunna, and Mari.
Sirukumab
Sirukumab (CNTO 136) is a fully human IgG1κ monoclonal antibody against interleukin-6 developed by Janssen for rheumatoid arthritis; effective in SIRROUND trials but never marketed after FDA and EMA rejections in 2017 over long-term safety.
SIRUP
SIRUP (シラップ) is a Japanese R&B singer-songwriter project from Osaka Prefecture, created by the artist formerly known as KYOtaro and debuted in September 2017 with "Synapse".
Sirupanarruppatai
Sirupanarruppatai (சிறுபாணாற்றுப்படை) is a classical Tamil Sangam poem, the third of the ten Pattuppattu idylls, in which poet Nathathanar directs a wandering bard to the patron Oyman Nalliyakodan.
Sirusho
Sirusho (Սիրուշո), born Siranush Harutyunyan in 1987 in Yerevan, is an Armenian pop singer and songwriter best known for finishing fourth at Eurovision 2008 with "Qele, Qele".
Siruthai
Siruthai (சிறுத்தை) is a 2011 Tamil action comedy directed by Siva, a remake of Rajamouli's Telugu hit Vikramarkudu, starring Karthi in a dual role as thief Rocket Raja and cop Ratnavel Pandian with Tamannaah and Santhanam; a Pongal 2011 box-office hit.
Siruthondar
Siruthondar (சிருத்தொண்டர்), born Paranjothi, was a Pallava commander under Narasimhavarman I who captured Vatapi in 642 and was later revered as one of the 63 Saiva Nayanar saints.
Sirventes
The sirventes was a satirical, moral, or political song genre of the troubadours of southern France, flourishing in the 12th and 13th centuries as an alternative to the courtly love song.
Sirwah
Sirwah (Ṣirwāḥ) is an ancient walled city of the kingdom of Saba in the Khawlān highlands of Yemen, about 40 km west of Marib, known for its Almaqah temple and royal inscriptions.
Siryn
Siryn (Theresa Maeve Rourke Cassidy) is a Marvel Comics mutant, daughter of Banshee, with a sonic scream up to 140 dB, flight, and sonic hypnosis; debuted in Spider-Woman #37 (1981), later X-Force member and X-Factor's Morrigan.
SIS (Soft Is Strong)
SIS (Soft Is Strong) is the debut EP of global girl group KATSEYE, released August 16, 2024 by HYBE x Geffen; five tracks about 11 minutes long, preceded by singles Debut and Touch, peaking at number 119 on the Billboard 200.
SIS Building
SIS Building, aka MI6 Building or Vauxhall Cross, at 85 Albert Embankment, London: Terry Farrell's 1994 postmodern ziggurat headquarters of Britain's Secret Intelligence Service, built by Regalian and featured in James Bond films.
SIS model
The SIS model is a compartmental epidemic model where individuals move from susceptible to infected and back to susceptible on recovery, with no lasting immunity; it suits gonorrhea and computer viruses.
SIS trial
SIS trial: NCT04599127, a completed Mahidol University randomized trial of Mulligan mobilization with movement added to conventional physical therapy in shoulder impingement syndrome; 22 participants in Jakarta, no results posted.