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Spleenworts in rock gardens and ferneries
Spleenworts in rock gardens and ferneries is the cultivation of small evergreen Asplenium ferns, including maidenhair spleenwort and hart's-tongue, which naturally grow on cliffs and walls and thrive in alkaline crevices with sharp drainage and shade.
Splenda
Splenda is an American brand of low- and zero-calorie sweeteners, launched in 1991 and owned by Heartland Food Products Group, whose original sucralose-based product is about 600 times sweeter than sugar.
Splendor in the Grass
Splendor in the Grass (1961) is Elia Kazan's drama from William Inge's Oscar-winning original screenplay, starring Natalie Wood and a debuting Warren Beatty as 1920s Kansas teens destroyed by sexual repression.
Splenectomy
Splenectomy is surgical removal of the spleen, done open, laparoscopic, or robotically for trauma, hematologic disorders, and splenomegaly; asplenic patients need lifelong pneumococcal, meningococcal, and Hib vaccination and antibiotic prophylaxis.
Splenic arteriovenous malformation
Splenic arteriovenous malformation (arteriovenous malformation of the spleen, ORPHA:693863) is an ultra-rare congenital shunt between the splenic artery and splenic vein at the splenic hilum, causing portal hypertension, splenic artery aneurysms, hemorrhage, and treated by embolization or splenectomy.
Splenic cyst
A splenic cyst is a fluid-filled cavity in the spleen, classified as a true epithelial-lined cyst, a pseudocyst, or a parasitic hydatid cyst; about 75% are pseudocysts, most following abdominal trauma.
Splenic diffuse red pulp lymphoma
Splenic diffuse red pulp lymphoma (SDRPL) is a rare, indolent B-cell non-Hodgkin lymphoma of small B cells infiltrating the splenic red pulp, typically causing massive splenomegaly.
Splenic infarction
Splenic infarction: death of spleen tissue from occlusion of the splenic artery or its branches. Also called splenic infarct. Causes include cardioembolism, hematologic disease, malignancy, sepsis; diagnosed by contrast-enhanced CT; usually managed conservatively.
Splenic injury
Splenic injury: trauma to the spleen, the most commonly injured organ in blunt abdominal trauma. Also called splenic trauma; treated by nonoperative management, embolization, or splenectomy, with NOM failure under 10% overall.
Splenic lymph nodes
Splenic lymph nodes (nodi splenici) lie at the splenic hilum, drain the spleen, pancreas body/tail, and stomach, and form gastric cancer station 10; key regional nodes in pancreatic and gastric cancer surgery.
Splenic macrophage
Splenic macrophages are the spleen's tissue-resident macrophage subsets: red pulp, marginal zone, metallophilic, and tingible body macrophages, which clear aged erythrocytes, recycle iron, filter blood-borne pathogens, and shape adaptive immunity.
Splenic marginal zone lymphoma
Splenic marginal zone lymphoma (SMZL) is a rare indolent B-cell non-Hodgkin lymphoma of the spleen, bone marrow, and blood, marked by 7q deletion, NOTCH2 and KLF2 mutations, and rituximab or splenectomy treatment.
Splenic sequestration crisis
Splenic sequestration crisis, also called acute splenic sequestration, is a sickle cell disease emergency in which red cells trap in the spleen, dropping hemoglobin by 2 g/dL or more; treated with transfusion, sometimes splenectomy.
Splenic vein
Splenic vein: large abdominal vein formed at the splenic hilum, draining spleen, pancreas, and stomach; joins the superior mesenteric vein behind the pancreatic neck to form the portal vein; key diseases are splenic vein thrombosis and left-sided portal hypertension.
Splenocyte
Splenocyte (Cell Ontology CL:2000074): any leukocyte that is part of the spleen; a vague umbrella term for splenic T cells, B cells, macrophages, and dendritic cells used in isolation and immune assays.
Splenomegaly
Splenomegaly, an enlarged spleen (over 12 cm length or 400 g), arises from portal hypertension, infections like EBV and malaria, infiltration, or hematopoiesis; massive splenomegaly exceeds 20 cm or 1000 g and risks rupture.
Splenorenal shunt
A splenorenal shunt is a surgical operation connecting the splenic vein to the left renal vein, lowering portal pressure to control variceal bleeding; the selective distal form dates to 1967.
Splenosis
Splenosis, also called splenic autotransplantation, is benign ectopic splenic tissue implanted after splenic trauma or splenectomy; diagnosed by Tc-99m heat-damaged RBC scintigraphy, it mimics malignancy and occurs in up to 65% of splenic ruptures.
Splice (film)
Splice (Nouvelle espèce) is a 2009 sci-fi horror film by Vincenzo Natali starring Adrien Brody, Sarah Polley, and Delphine Chanéac as Dren, a human-animal hybrid; Sundance premiere 2010, Warner Bros. release, 75% on Rotten Tomatoes.
Splice Bio
SpliceBio is a clinical-stage Barcelona genetic medicines company founded in 2020, whose lead candidate SB-007, a dual AAV gene therapy for Stargardt disease, entered clinical trials in 2025.
Splice site mutation
Splice site mutation: a DNA change disrupting spliceosome recognition of exon-intron boundaries (GT donor, AG acceptor dinucleotides), causing exon skipping, intron retention, or cryptic site use; a major cause of genetic disease, targetable by splice-switching antisense oligonucleotides.
Splice site prediction
Splice site prediction is the computational identification of splice donor and acceptor sites in DNA or RNA, using machine-learning models to support gene annotation and variant interpretation.
Splice the mainbrace
Splice the mainbrace: naval order for a celebratory issue of rum, from repairing a square-rigged ship's largest rigging; ordered only by royalty or Admiralty, retained after the 1970 rum-ration abolition.
Splice-site recognition and consensus sequences
Splice-site recognition is how the spliceosome locates the short motifs marking where an intron begins and ends; in mammals, consensus sequences are too loose to specify splicing alone.
SpliceBio
SpliceBio is a clinical-stage genetic medicines company in Barcelona, founded in 2020, whose dual AAV protein splicing platform backs SB-007, a gene therapy for Stargardt disease now in Phase 1/2 trials.
Spliceosome
Spliceosome: nuclear RNA-protein machine (U1, U2, U4, U5, U6 snRNPs plus ~150 proteins) that removes introns from pre-mRNA via two transesterifications; a parallel minor spliceosome (U11, U12, U4atac, U6atac, shared U5) splices ~0.5% of introns.
Spliceosome assembly pathway
The spliceosome assembly pathway is the ordered sequence of complexes through which the spliceosome forms on pre-mRNA, spanning at least 10 states from E to the intron-lariat spliceosome.
Splicing analysis methods and resources
Splicing analysis methods and resources are the computational tools for detecting and quantifying alternative splicing in RNA-seq, spanning event-level callers like rMATS and long-read isoform tools like IsoQuant.
Splicing factor U2AF
U2AF (U2AF65/U2AF35 heterodimer, U2AF2/U2AF1) is the essential splicing factor that binds the polypyrimidine tract and 3' splice site AG to define 3' splice sites and recruit U2 snRNP.
SPLID trial
SPLID (NCT05041829) is a pilot single-center crossover single-blind randomized controlled trial at UC Irvine testing low versus high dietary sodium intake for blood pressure, kidney function, and proteinuria in living kidney donors 5-12 months post-donation; currently suspended.