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Alpra trial
Alpra (NCT03702803) is a Mexican IMSS Phase 2 double-blind randomized trial comparing Galphimia glauca standardized extract (0.374 mg Galphimine-B) with alprazolam 1 mg daily for 10 weeks in generalized anxiety disorder; published results showed similar efficacy with less daytime sleepiness.
Alprazolam
Alprazolam (Xanax) is a short-acting, high-potency Schedule IV benzodiazepine approved in 1981 for generalized anxiety and panic disorder, with rapid onset, CYP3A4 metabolism, and prominent withdrawal and misuse risks.
Alprenolol
Alprenolol is a non-selective beta blocker of the aryloxypropanolamine type, introduced in 1966 to treat hypertension, angina, and arrhythmia; no longer marketed by AstraZeneca, it may remain available generically.
Alps
The Alps, Europe's great fold mountain system from the Col d'Altare to the Semmering, formed by Cretaceous and Tertiary collision of the Adriatic and European margins; now facing severe glacier retreat, tourism pressure, and Alpine Convention governance.
Alps (2011 film)
Alps (Alpeis, Άλπεις) is a 2011 Greek drama by Yorgos Lanthimos, written with Efthimis Filippou, about a secret group impersonating the dead for grieving families; it won Venice's Best Screenplay Osella.
ALPS II
ALPS II (Any Light Particle Search II) is a light-shining-through-a-wall experiment at DESY in Hamburg that searches for axions and axion-like particles, dark-matter candidates, using laser light and strong magnets.
ALPS-treated water release
The ALPS-treated water release is the controlled discharge into the Pacific Ocean of treated water from the Fukushima Daiichi nuclear plant, begun by TEPCO in 2023.
Alptakin
Alptakin (الپتکین), also written Aftakin or Haftakin and known as Abu Mansur, was a Turkish commander who led the Buyid ghulams, rebelled in Baghdad, and ruled Damascus from 974.
Alptigin's conquest of Ghazna
Alptigin's conquest of Ghazna in 962 CE was the seizure of the town in eastern Afghanistan by a Turkic military slave commander. He made it an autonomous principality.
Alptigin's seizure of Ghazna
Alptigin's seizure of Ghazna (تصرف البتکین بر غزنه) was the capture of Ghazna, in eastern Afghanistan, by the Samanid Turkish commander Alptigin in 962, after a failed coup in Bukhara.
Alqama al-Nakha'i
Alqama al-Nakha'i (علقمة النخعي) was a Kufan jurist and Quran reciter of the Successor generation, a leading disciple of Abdullah ibn Mas'ud who died in 681/682.
Alqas Mirza
Alqas Mirza (القاس میرزا) was a Safavid prince, the second son of Shah Esmail I, who governed Shirvan before revolting against his brother Shah Tahmasp in the 1540s.
Alqueva Dam
The Alqueva Dam is a 96-meter concrete arch dam on the Guadiana River in Alentejo, southern Portugal, closed in 2002 to store water for irrigation and supply.
Alrar gas field
The Alrar gas field (الرار) is a gas-condensate field in the Illizi Basin of southeastern Algeria, near the Libyan border, discovered in 1961 and producing commercially since 1987.
AlRashed Group
AlRashed Group, formally Rashed Abdul Rahman AlRashed & Sons Group (مجموعة راشد عبدالرحمن الراشد وأولاده), is a family-owned Saudi conglomerate founded in 1950 and based in Al Khobar.
AlRawabi School for Girls (مدرسة الروابي للبنات)
AlRawabi School for Girls (مدرسة الروابي للبنات) is a Jordanian Netflix teen drama created by Tima Shomali, premiering 12 August 2021, about bullied girls at an elite Amman school seeking revenge; two seasons, 12 episodes.
AlRayan Bank
AlRayan Bank PLC is the UK's oldest and largest Sharia-compliant bank, incorporated in 2002 as Islamic Bank of Britain and renamed in 2014, with assets over £3 billion.
Alresford
Alresford names two English places: Old and New Alresford in Hampshire, a bishop of Winchester's planned market town on the Winchester-London road, and a Tendring, Essex village with an 1885-excavated Roman villa (Pleiades 79291).
Alright (Kendrick Lamar song)
Alright is a 2015 Kendrick Lamar song from To Pimp a Butterfly, produced by Pharrell Williams and Sounwave. Its chorus became a Black Lives Matter protest chant, and it won Best Rap Song and Best Rap Performance at the 2016 Grammys.
Alrizomadlin
Alrizomadlin (APG-115, AA-115) is Ascentage Pharma's oral spiro-oxindole MDM2-p53 inhibitor (IC50 3.8 nM) in phase I/II cancer trials, with six FDA orphan drug designations and no approval yet.
Alrosa
Alrosa, also known as PJSC ALROSA, is a Russian state-controlled diamond mining company founded in 1992 in Mirny, Yakutia, and the world's largest diamond miner.
ALS
ALS (amyotrophic lateral sclerosis, Lou Gehrig's disease) is a fatal motor neuron disease causing progressive paralysis; most die within 3-5 years of symptom onset; riluzole, edaravone, and tofersen are approved treatments.
ALS Functional Rating Scale - Revised
ALSFRS-R (ALS Functional Rating Scale-Revised), 12-item 0-48 ordinal scale for ALS disability across bulbar, fine motor, gross motor, and respiratory domains; 1999 Cedarbaum revision, standard clinical trial primary outcome.
ALS inhibitor herbicides
ALS inhibitor herbicides are weed killers that block acetolactate synthase, halting valine, leucine, and isoleucine synthesis; the largest herbicide group, with 58 actives across five families.
ALS study (NCT00821132)
NCT00821132, "Genetics of Familial and Sporadic ALS," is a Northwestern University observational genetic study led by Teepu Siddique, running 1991 to 2023 with 13,521 enrollees, collecting blood, CSF, and tissue samples from ALS families to identify ALS risk genes.
ALS–frontotemporal spectrum
The ALS–frontotemporal spectrum is a continuum of neurodegenerative disease in which amyotrophic lateral sclerosis and frontotemporal dementia overlap, sharing TDP-43 pathology and C9orf72 genetics, formally termed ALS-FTSD.
Alsace
Alsace (Elsass), eastern French territory between Vosges and Rhine; capital Strasbourg. Former French province, German Reichsland 1871-1918, reannexed 1940-44; since 2021 the Collectivité européenne d'Alsace within Grand Est.
Alsace–Lorraine
Alsace-Lorraine (Elsass-Lothringen), the imperial territory Germany annexed from France in 1871 after the Franco-Prussian War; granted a constitution in 1911; restored to France by the 1919 Treaty of Versailles.
Alsace–Lorraine Soviet Republic
Short-lived council republic proclaimed in Strasbourg in November 1918 during the German Revolution in Alsace-Lorraine (Räterepublik Elsaß-Lothringen); workers' and soldiers' councils spread regionally, then dissolved as French troops occupied the province.
Alsafa
Al Safa (الصفا) is a Dubai residential district around Safa Park, the city's first central public park (1975), between Al Wasl Road and Sheikh Zayed Road; distinct from same-named areas in Jeddah, Riyadh, and Najran.