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Hsp70
Hsp70 (70 kDa heat shock protein, DnaK in bacteria) is a conserved ATP-driven molecular chaperone family that folds, translocates, and disaggregates proteins; discovered by Ritossa in Drosophila in 1962, with 13 human members including Hsp72, BiP, and mortalin.
Hsp90
Hsp90 is a family of about 90-kDa molecular chaperones that use ATP-driven conformational cycles to mature client proteins, including kinases, transcription factors, and E3 ubiquitin ligases.
Hsp90 buffering of genetic variation
Hsp90 buffering of genetic variation is the ability of the Hsp90 chaperone to hide the effects of genetic variants until stress or inhibition reveals them, making Hsp90 a capacitor of variation.
HSP90AA1
HSP90AA1 (Hsp86, HspC1) is the human chromosome 14q32.31 gene encoding Hsp90α, the stress-inducible cytosolic Hsp90 chaperone isoform, a homodimeric ATPase distinct from the essential constitutive paralog HSP90AB1.
HSP90AB1
HSP90AB1 (HSP 90-beta, Hsp90β, HSP84) is the human chromosome 6p21.1 gene encoding the constitutive cytosolic 90 kDa heat shock protein chaperone, an ATPase that matures client kinases and hormone receptors, distinct from stress-inducible HSP90AA1.
HSP90B1
HSP90B1 (GRP94, gp96, endoplasmin) is the human gene at 12q23.3 encoding the ER-resident HSP90-family chaperone that folds Toll-like receptors, integrins, and IGF clients; its regulated glycosylation links to osteogenesis imperfecta and cancer prognosis.
HSPA
HSPA (High Speed Packet Access) is a set of packet-data enhancements to WCDMA, the 3G mobile air interface standardized by 3GPP, combining HSDPA downlink and HSUPA uplink.
HSPA+
HSPA+, or HSPA Evolution, is a mobile broadband technology that extends 3G WCDMA networks with MIMO and dual-carrier operation, standardized in 3GPP Release 7 in 2007.
HSPA1A
HSPA1A (HSP70-1, HSP72) is a human intronless gene at 6p21.33 in the MHC class III region encoding the major stress-inducible 70 kDa Hsp70 chaperone, regulated by HSF-1, NF-Y, NF-kB, and CREB.
HSPA1B
HSPA1B (HSP70-2), human intronless gene at 6p21.33 in the MHC class III region, encodes a 70 kDa stress-inducible Hsp70 chaperone nearly identical to HSPA1A, HSF1-regulated, with eQTL rs400547 and male-fertility roles in mouse knockout.
HSPA6
HSPA6 (HSP70B′), heat shock protein family A member 6, Gene ID 3310 at 1q23.3: a strictly stress-inducible human Hsp70 chaperone, 643 aa, binding only Class B JDPs, implicated in cancer prognosis and drug resistance.
HSPA8
HSPA8, also called HSC70 or HSP73, is the human chromosome 11 gene encoding the constitutive Hsp70-family chaperone that folds nascent proteins, uncoats clathrin vesicles, and drives chaperone-mediated autophagy, unlike stress-inducible HSPA1A.
HSPA9
HSPA9 (mortalin, mtHSP70, GRP75, PBP74) is a human chromosome 5q31.2 gene encoding the mitochondrial HSP70 chaperone that drives protein import, folding, iron-sulfur cluster biogenesis, and mitophagy; mutations cause EVEN-PLUS syndrome and sideroblastic anemia.
HSPB1
HSPB1 (HSP27, heat shock protein beta-1) is a human small heat shock protein gene encoding an ATP-independent chaperone; mutations cause Charcot-Marie-Tooth disease type 2F and distal hereditary motor neuropathy 2B.
HSPB1-associated protein 1
HSPB1-associated protein 1 (HSPBAP1, PASS1, UniProt Q96EW2) is a 488-aa human JmjC-domain protein binding HSPB1/HSP27, suppressing its heat-shock protection; upregulated in intractable epilepsy temporal neocortex.
HSPB8
HSPB8 (Hsp22, H11, E2IG1) is a 22 kDa human small heat shock protein on chromosome 12q24.23 that binds BAG3 to drive chaperone-assisted selective autophagy; mutations cause dHMN2A, CMT2L, and myofibrillar myopathy.
HSPD1
HSPD1 (HSP60, CPN60, SPG13) is a human gene at 2q33.1 encoding the mitochondrial chaperonin Hsp60, which folds about half of mitochondrial matrix proteins; mutations cause SPG13 hereditary spastic paraplegia and hypomyelinating leukodystrophy.
HSPF (hydrology)
HSPF (Hydrological Simulation Program–FORTRAN) is a US EPA watershed model that continuously simulates runoff and water quality, recommended for complex TMDL studies and distributed with BASINS.
HSPG2
HSPG2, heparan sulfate proteoglycan 2, is a protein-coding gene on chromosome 1p36.12 that encodes perlecan, a large basement membrane proteoglycan; biallelic mutations cause Schwartz-Jampel syndrome type 1 and lethal dyssegmental dysplasia.
HSPICE
HSPICE is a commercial SPICE circuit simulator for transistor-level simulation of analog, RF, and mixed-signal integrated circuits, commercialized from Berkeley SPICE by Meta-Software and now sold by Synopsys.
HSST
HSST (High Speed Surface Transport) is a Japanese normal-conducting maglev system that levitates vehicles by electromagnetic attraction and entered commercial service in 2005 on Aichi's Linimo line.
HSTikkyTokky
HSTikkyTokky, real name Harrison Sullivan (born 2001), is a British influencer from Essex known for fitness and crypto content, Kick streaming, one crossover boxing win, a 2024 court case, and Louis Theroux's manosphere documentary.
Hsu Kai-li
Hsu Kai-li (許介立, Jerry Hsu) is a Taiwanese executive who chairs AcBel Polytech, Kinpo Electronics, and Cal-Comp Electronics, and is the only son of Kinpo Group founder Hsu Sheng-hsiung.
Hsu Shu Ching
Hsu Shu Ching (許淑淨), born 1991, Taiwanese weightlifter for Chinese Taipei, women's 53 kg. Two Olympic golds (London 2012 upgraded, Rio 2016), 233 kg world record at Incheon 2014; retired 2018, later banned three years for doping.
Hsu Wei-ning (许玮宁)
Hsu Wei-ning (許瑋甯, Tiffany Hsu, Ann Hsu), Taiwanese actress born 1984, former model; Golden Bell Best Supporting Actress 2015 and back-to-back miniseries Best Actress 2023–2024; married Roy Chiu 2021.
HSUPA
HSUPA (High Speed Uplink Packet Access) is the uplink enhancement of WCDMA mobile networks, standardized in 3GPP Release 6 in 2004 and deployed commercially from around 2007.
HT Cas
HT Cas is a deeply eclipsing dwarf nova in Cassiopeia, an SU Ursa Majoris-type cataclysmic binary whose 106-minute orbit and eclipses let astronomers map its accretion disc.
HT-1080
HT-1080 (HT1080, CVCL_0317, ATCC CCL-121) is a human fibrosarcoma cancer cell line established in 1972 from a 35-year-old man; NRAS-mutant, IDH1 R132C, used in sarcoma research, 3D migration studies, and Shire therapeutic protein manufacturing.
HT-1376
HT-1376 (HT1376, CVCL_1292) is a human bladder transitional cell carcinoma cell line established in 1977 from a 58-year-old woman, near-tetraploid, with RB1, TP53, TERT promoter, and PTEN alterations, used in muscle-invasive bladder cancer research.
HT-29
HT-29 (ATCC HTB-38, CVCL_0320) is a human colorectal adenocarcinoma cell line established in 1964 by J. Fogh from a 44-year-old woman's colon tumor; adherent, enterocyte-like, drug-sensitive, and widely used in cancer, GI barrier, and CRISPR screening research.