All articles A–Z
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Adenomyosis
Adenomyosis: benign growth of endometrial glands and stroma within the uterine muscle (myometrium), first described by Rokitansky in 1860. Causes painful heavy periods and pelvic pain; diagnosed by ultrasound or MRI; treated with hormonal therapy or surgery.
Adenophora
Adenophora Fisch. (ladybells) is a Campanulaceae genus of perennial herbs native from temperate Eurasia to Indo-China, defined by a nectar disk between stamens and pistils; about 68 species, revised phylogenomically in 2025. Distinct from Ageratina adenophora.
Adenosarcoma of the cervix uteri
Adenosarcoma of the cervix uteri (cervical Müllerian adenosarcoma) is a rare biphasic malignant tumor with benign glands and malignant stroma, 0.16% of cervical cancers, presenting as bleeding or a polyp, with favorable prognosis after surgery.
Adenosine
Adenosine (CAS 58-61-7) is a purine ribonucleoside of adenine and ribose, an RNA building block and stress signal acting at A1, A2A, A2B, A3 receptors; FDA-approved 1989 for supraventricular tachycardia.
Adenosine A2B receptor
Adenosine A2B receptor (A2BR, ADORA2B), one of four adenosine GPCRs; low-affinity (EC50 24 μM), Gs/Gq-coupled, activated in hypoxia and inflammation; target in cancer, asthma, diabetes, cardiovascular disease.
Adenosine A3 receptor
Adenosine A3 receptor (A3AR, ADORA3): a Gi/o-coupled GPCR, the fourth and most species-variable adenosine receptor subtype, overexpressed in inflammatory and cancer cells and targeted by clinical agonists piclidenoson and namodenoson.
Adenosine deaminase
Adenosine deaminase (ADA, EC 3.5.4.4), a zinc enzyme on chromosome 20 converting adenosine to inosine; its deficiency causes ADA-SCID, treated by PEG-ADA enzyme replacement, HSCT, and gene therapy.
Adenosine diphosphate
Adenosine diphosphate (ADP), adenosine pyrophosphate, is the two-phosphate product of ATP hydrolysis, regenerated to ATP by ATP synthase, central to energy charge, and a platelet P2Y1/P2Y12 agonist targeted by clopidogrel.
Adenosine kinase
Adenosine specific kinase (adenosine kinase, ADK, EC 2.7.1.20) is a conserved PfkB-family enzyme phosphorylating adenosine to AMP, regulating adenosine tone, DNA methylation via ADK-L, and a drug target for epilepsy and inflammation.
Adenosine monophosphate
Adenosine monophosphate (AMP), also called 5'-adenylic acid or adenylate, is a nucleotide of RNA made of adenine, ribose, and one phosphate, signaling cellular energy status and activating AMPK.
Adenosine monophosphate as a flavor enhancer
Adenosine monophosphate (AMP) is a purine ribonucleotide used as a food flavor enhancer and bitterness blocker, recognized as safe in the United States since 2004.
Adenosine monophosphate deaminase deficiency
Adenosine monophosphate deaminase deficiency (myoadenylate deaminase deficiency, AMPD1 deficiency) is an autosomal recessive metabolic myopathy caused mainly by the AMPD1 C34-T nonsense mutation, causing exercise-induced fatigue, cramps, and myalgia in a minority of homozygotes.
Adenosine receptor
Adenosine receptors (A1, A2A, A2B, A3; ADORA genes) are P1 class A GPCRs activated by adenosine, coupling to Gi/o or Gs, mediating cardioprotection, neurotransmission and tumor immunosuppression, targeted by caffeine, regadenoson and istradefylline.
Adenosine triphosphate
Adenosine triphosphate (ATP), the cell's energy currency: adenine, ribose, and three phosphates; hydrolysis releases −7.3 kcal/mol standard; discovered by Lohmann in 1929, structure solved 1935; ~32 ATP per glucose.
Adenosylcobalamin
Adenosylcobalamin (AdoCbl, coenzyme B12, 5'-deoxyadenosylcobalamin) is the mitochondrial active form of vitamin B12, coenzyme of methylmalonyl-CoA mutase, formed via aerobic or anaerobic cobalamin biosynthetic pathways.
Adenotonsillectomy
Adenotonsillectomy is an operation that completely removes the palatine tonsils together with the adenoids, most often performed in children to relieve sleep-disordered breathing or recurrent throat infection.
Adenotrophic viviparity
Adenotrophic viviparity is gland-fed live birth in flies such as tsetse (Glossina) and other Hippoboscoidea: a single intrauterine larva is nourished by milk gland secretions, about 50% lipid and 50% protein, until parturition.
Adenoviridae
Adenoviridae (adenoviruses): non-enveloped icosahedral dsDNA virus family, 90 nm virions, 25–48 kb genomes, six genera infecting vertebrates from fish to humans; causes respiratory, enteric, and ocular disease and serves as a gene-therapy and vaccine vector.
Adenovirus E3
Adenovirus E3 (early region 3) is a nonessential adenovirus transcription unit encoding immunomodulatory proteins such as E3-19K, RID, 14.7K, and the adenovirus death protein, and is commonly deleted from gene therapy and vaccine vectors.
Adenovirus infection
Adenovirus infection, caused by human adenoviruses (HAdV, Mastadenovirus), is typically a mild cold-, flu-, conjunctivitis-, or gastroenteritis-like illness; no approved antivirals exist, and the live types 4/7 oral vaccine is restricted to US military personnel.
Adenylosuccinate lyase
Adenylosuccinate lyase is an enzyme unique in the purine biosynthetic pathway, catalyzing two reactions to produce AMP and AICAR. Loss of its function causes a rare neurometabolic disorder.
Adenylosuccinate lyase deficiency
Adenylosuccinate lyase deficiency (ADSLD, adenylosuccinase deficiency) is a rare autosomal recessive purine metabolism disorder (ADSL gene, 22q13.1-q13.2) causing psychomotor delay, drug-resistant seizures, and autistic features, diagnosed by SAICAr and S-Ado in body fluids.
Adenylosuccinate synthetase
Adenylosuccinate synthetase (AdSS) is an enzyme that catalyzes the first committed step toward AMP in de novo purine biosynthesis, coupling GTP hydrolysis to adenylosuccinate formation.
Adenylyl cyclase
Adenylyl cyclase (EC 4.6.1.1) converts ATP to the second messenger cAMP. Ten mammalian isoforms: nine G-protein-regulated transmembrane enzymes (AC1–9) and bicarbonate/calcium-regulated soluble sAC (AC10), an intracellular pH sensor.
Adenylyl-sulfate reductase
Adenylyl-sulfate reductase (APS reductase, EC 1.8.99.2) reduces adenosine 5′-phosphosulfate to sulfite and AMP. The dissimilatory iron-sulfur flavoenzyme (FAD plus two [4Fe-4S] clusters) drives anaerobic sulfate respiration; unrelated assimilatory forms regulate plant sulfur assimilation.
Adeodatus
Adeodatus (c. 372 – c. 388 or 390) was the son of Augustine of Hippo, remembered as the gifted interlocutor of Augustine's dialogue De magistro.
Adeodatus II
Adeodatus II, also called Deusdedit II, was the 77th pope, reigning from 672 until his death in 676, an obscure Roman and former Benedictine monk.
Adeona family
The Adeona family is a C-complex asteroid family in the central main belt named after (145) Adeona, formed in a cratering event about 700 Myr ago, primitive and aqueously altered, host of active asteroid P/2016 G1.
Adepero Oduye
Adepero Oduye (born 1978), American actress of Nigerian descent from Brooklyn, known for Alike in Pariah, Eliza in 12 Years a Slave, The Big Short, and her Nina Simone short To Be Free in the Smithsonian collection.
Adephaga
Adephaga is the second largest beetle suborder, over 45,000 predatory species in 11 families, including ground beetles, tiger beetles, diving beetles, and whirligig beetles, with a Permian origin and paraphyletic aquatic Hydradephaga.