5 articles
Cone snail
Cone snail, genus Conus (Conidae), venomous predatory marine gastropod hunting fish, mollusks, and worms with harpoon-like radular teeth; venom conotoxins yielded the FDA-approved pain drug ziconotide (Prialt) from Conus magus; 750+ species; C. geographus most dangerous to humans.
Conotoxin
Conotoxins are small, disulfide-rich peptide neurotoxins produced by predatory marine cone snails, which act potently on ion channels and receptors, paralyzing prey and yielding the FDA-approved pain drug ziconotide.
Conus geographus
Conus geographus, the geography cone (Gastridium), is an Indo-West Pacific fish-hunting cone snail, the deadliest to humans: about 57% of recorded cone snail envenomations and almost all 36 fatalities from 1670 to 2017 are attributed to it.
omega-conotoxin GVIA
omega-Conotoxin GVIA is a 27-amino-acid peptide from the venom of the cone snail Conus geographus that blocks N-type calcium channels and has served since the mid-1980s as the standard pharmacological probe for identifying those channels.
Ziconotide
Ziconotide (Prialt, SNX-111), a synthetic cone snail venom peptide from Conus magus, is the only FDA-approved non-opioid intrathecal analgesic; it blocks N-type calcium channels for severe refractory chronic pain, with no tolerance or respiratory depression but a narrow therapeutic window.