2 articles
Deoxyribonuclease
Deoxyribonuclease (DNase), EC 3.1.-, any enzyme hydrolyzing phosphodiester bonds in DNA. Two families: cation-dependent neutral-pH DNase I and cation-independent acidic DNase II; dornase alfa treats cystic fibrosis.
Deoxyribonuclease II
Deoxyribonuclease II (DNase II, acid DNase, DNase IIα) is a lysosomal endonuclease active at pH ~5.2 without divalent cations, leaving 3'-phosphate/5'-OH ends; essential for apoptotic and erythroid DNA clearance, lethal when knocked out in mice.