35 articles
Prephenate dehydrogenase
Prephenate dehydrogenase (PDH, TyrA, EC 1.3.1.12) is a TyrA-family oxidoreductase catalyzing NAD+-dependent oxidative decarboxylation of prephenate to 4-hydroxyphenylpyruvate in tyrosine biosynthesis; monofunctional or fused to chorismate mutase in enteric bacteria.
Saccharopine dehydrogenase [NAD(+), L-lysine-forming]
Saccharopine dehydrogenase [NAD(+), L-lysine-forming] (EC 1.5.1.7, SDH, yeast LYS1) catalyzes saccharopine + NAD+ to lysine + α-ketoglutarate, the final step of fungal lysine biosynthesis, with an ordered NAD-first mechanism.
Shikimate dehydrogenase
Shikimate dehydrogenase (SDH, EC 1.1.1.25, AroE) is the NADPH-dependent enzyme of the fourth shikimate pathway step, reducing 3-dehydroshikimate to shikimate in plants and microbes; absent in mammals, it heads a five-class enzyme family and is a herbicide and antimicrobial drug target.
Succinate semialdehyde dehydrogenase
Succinate semialdehyde dehydrogenase (SSADH, ALDH5A1) is a mitochondrial NAD+-dependent enzyme oxidizing succinic semialdehyde to succinate in the GABA shunt; its deficiency causes SSADHD, a rare epileptic encephalopathy with GHB accumulation.
Xanthine dehydrogenase D subunit
Xanthine dehydrogenase D subunit (pucD, TIGR03196) is the molybdopterin- and xanthine-binding subunit of bacterial xanthine dehydrogenase, working with FAD-binding PucC and FeS-binding PucE; counterpart of R. capsulatus XdhB.