3 articles
Complement receptor 1
Complement receptor 1 (CR1, CD35), a 30-CCP-domain transmembrane RCA-family protein on leukocytes, erythrocytes, and podocytes, binds C3b/C4b, accelerates convertase decay, acts as a factor I cofactor, and clears immune complexes.
Factor H
Factor H (CFH) is a 150-kDa, 20-domain soluble plasma glycoprotein that regulates the complement alternative pathway by competing with factor B, accelerating convertase decay, and serving as factor I cofactor; linked to aHUS, AMD, and C3 glomerulopathy.
Regulation of complement convertases
Regulation of complement convertases covers the mechanisms controlling the unstable C3 convertases C4b2a and C3bBb, including decay acceleration, factor I cofactor activity, and properdin stabilization.