3 articles
Aliskiren
Aliskiren (Tekturna, Rasilez) is the first and only marketed direct renin inhibitor, approved in 2007 for adult hypertension. It lowers blood pressure similarly to ACE inhibitors and ARBs but must not be combined with them in diabetes or renal impairment.
Renin
Renin: kidney enzyme, discovered by Tigerstedt and Bergman in 1898, that catalyzes the rate-limiting first step of the renin-angiotensin system, cleaving angiotensinogen; target of the direct renin inhibitor aliskiren.
Renin–angiotensin system
Renin–angiotensin system (RAAS), hormonal cascade of renin, angiotensin II, and aldosterone regulating blood pressure and volume; discovered from 1898, targeted by ACE inhibitors, ARBs, and renin inhibitors.