Core 3 and 4 synthases and O-glycan elongation activities

Core 3 and core 4 O-glycan synthases and O-glycan elongation

Core 3 and core 4 O-glycan synthases are Golgi enzymes, B3GNT6 and GCNT3, that build branched mucin-type O-glycans in gastrointestinal tissues and are down-regulated in colorectal cancer.