6 articles
DUSP6
DUSP6 (MKP-3, Pyst1) is a cytoplasmic, ERK1/2-specific dual-specificity phosphatase at 12q21.33 that dephosphorylates ERK's T-X-Y motif as an FGF/ERK negative feedback regulator, with developmental and cancer roles.
Laforin
Laforin, product of the EPM2A gene at 6q24, is the animal kingdom's only carbohydrate-binding dual-specificity phosphatase, a glucan phosphatase whose loss causes fatal Lafora disease.
Protein tyrosine phosphatase
Protein tyrosine phosphatases (PTPs, EC 3.1.3.48), enzymes dephosphorylating phosphotyrosine; over 100 human members, HC(X)5R motif, Cys215 nucleophile, two-step cysteinyl-phosphate mechanism, drug targets like PTP1B and SHP2.
PTPN2
PTPN2, also called TCPTP or TC-PTP, encodes a ubiquitous non-receptor protein tyrosine phosphatase on chromosome 18p11 with nuclear (TC45) and ER (TC48) isoforms, regulating insulin, JAK/STAT, and TCR signaling, autoimmune risk, and cancer immunotherapy.
PTPN22
PTPN22 is a human gene on chromosome 1 that encodes lymphoid tyrosine phosphatase, which dampens T cell receptor signaling; its C1858T variant is among the strongest genetic risk factors for autoimmunity.
Tyrosine-protein phosphatase 1
Tyrosine-protein phosphatase 1 (Ptp1, PTP1/YDL230W) is a 335-aa protein tyrosine phosphatase of Saccharomyces cerevisiae, EC 3.1.3.48, nonessential, that dephosphorylates Cdk1-Y19 redundantly with Mih1 and PP2A-Rts1 and is dispensable for MAPK regulation.