2 articles
Kynurenic acid
Kynurenic acid (KYNA), a tryptophan metabolite of the kynurenine pathway, is an endogenous neuroprotective antagonist at the NMDA glycine site and GPR35 agonist; its nicotinic receptor activity is disputed.
Kynurenine
Kynurenine, first product of tryptophan degradation via the kynurenine pathway (discovered 1925, Matsuoka and Yoshimatsu), branches into kynurenic acid, quinolinic acid, and NAD+; an AhR-activating immunometabolite and biomarker in psychiatry, cancer, and neurodegeneration.