3 articles
Cation efflux
Cation efflux via the cation diffusion facilitator (CDF, SLC30A/ZnT/MTP) family: ubiquitous Me2+/H+ antiporters exporting Zn, Cd, Co, Fe, Ni, Mn from cytoplasm; six TMDs plus CTD; linked to diabetes and neurodegeneration.
Trace metal transporters
Trace metal transporters are membrane proteins that move transition metal ions such as copper, zinc, and iron across biological membranes, using ATP-driven pumps and ABC importers.
Wilson disease protein
Wilson disease protein (ATP7B) is a copper-transporting P-type ATPase on chromosome 13q that loads ceruloplasmin and exports copper into bile; its mutation causes Wilson disease, now targeted by AAV gene therapy trials.