3 articles
Benzylisoquinoline alkaloid biosynthesis
Benzylisoquinoline alkaloid biosynthesis is the plant metabolic pathway that converts tyrosine-derived dopamine into (S)-reticuline, the branch point for morphine, codeine, berberine, and sanguinarine, worked out chiefly in opium poppy.
Emetine
Emetine is an isoquinoline alkaloid from ipecacuanha root, first isolated in 1817 by Pierre-Joseph Pelletier, used historically as an emetic and against amoebic dysentery until superseded by metronidazole.
Sanguinarine
Sanguinarine, also called pseudochelerythrine, is a benzophenanthridine alkaloid found in bloodroot and other Papaveraceae plants, known for intercalating DNA, killing microbes and cells, and causing epidemic dropsy from mustard oil adulteration.