3 articles
ABCG1
ABCG1 (ATP-binding cassette subfamily G member 1, formerly ABC8) is a human ABC half-transporter on chromosome 21q22.3 that homodimerizes to export cholesterol and oxysterols to mature HDL, not lipid-poor apoA-I, in reverse cholesterol transport.
ABCG2
ABCG2 (BCRP, breast cancer resistance protein) is an ATP-binding cassette half-transporter homodimer that pumps urate and many drugs out of cells; its Q141K (rs2231142) variant is the primary genetic cause of gout in East Asians and alters statin and anticancer drug exposure.
ABCG5 and ABCG8 sterol transporter
ABCG5/ABCG8 (G5G8, sterolins) is an obligate heterodimeric ABC transporter of enterocyte and hepatocyte apical membranes that exports cholesterol and xenosterols into gut lumen and bile; mutations cause sitosterolemia.