5 articles
Arp2/3 complex
Arp2/3 complex, also called ARP2/3 or actin-related protein 2/3 complex, is a seven-subunit eukaryotic actin nucleator that creates 70° branched actin filament networks, activated by WASP/WAVE nucleation-promoting factors, ATP, and actin; linked to Wiskott-Aldrich syndrome, ARPC1B immunodeficiency, and cancer invasion.
Axoneme
Axoneme: the microtubule core of eukaryotic cilia and flagella, typically 9+2 (nine doublet microtubules plus a central pair) in motile cilia and 9+0 in nonmotile primary cilia, with dynein motors driving beating.
Dynactin
Dynactin is a 1 MDa, 23-subunit protein complex required to activate cytoplasmic dynein-1 for processive microtubule minus-end transport. Built on an Arp1 filament with p150Glued, it needs coiled-coil adaptors like BICD2 or Hook3 to activate dynein.
Dynamitin
Dynamitin (p50, DCTN2) is the 50-kDa dynactin subunit forming a shoulder tetramer that docks p150Glued to the Arp1 filament; its overexpression disassembles dynactin and inhibits dynein motility.
Troponin T
Troponin T (TnT), encoded by TNNT1, TNNT2, and TNNT3, is the tropomyosin-binding subunit of the troponin complex regulating striated muscle contraction; cardiac cTnT is a key heart-attack blood biomarker.