6 articles
CD86
CD86 (B7-2, B70), gene ID 942, is a type I membrane protein of the immunoglobulin superfamily on antigen-presenting cells; it ligates CD28 (costimulation) and CTLA-4 (inhibition), with weaker affinity than CD80.
LRBA
LRBA (LPS Responsive Beige-Like Anchor Protein) is a BEACH-domain gene on chromosome 4 that recycles the CTLA-4 receptor in T cells; biallelic mutations cause LRBA deficiency (LATAIE), an autosomal recessive immunodeficiency with autoimmunity, treated with abatacept, sirolimus, or HSCT.
PDCD1LG2
PDCD1LG2 (PD-L2, B7-DC, CD273) is a human chromosome 9 gene encoding a B7-family ligand of PD-1, binding it 2-6-fold more strongly than PD-L1 and also binding RGMb; studied as a cancer immunotherapy target.
T-cell surface protein tactile
T-cell surface protein tactile, also called CD96, is an inhibitory immune checkpoint receptor on T cells and NK cells, encoded by the human CD96 gene.
TNFRSF4
TNFRSF4 (OX40, CD134, ACT35) is a human chromosome 1p36.33 gene encoding a 277-amino-acid TNF receptor superfamily costimulatory receptor for OX40L on activated T cells, an HHV-6B receptor linked to combined immunodeficiency IMD16.
VTCN1
VTCN1 (B7-H4, B7x, B7S1) is a human gene encoding a B7-family type I transmembrane immune checkpoint glycoprotein that inhibits T-cell proliferation; overexpressed in ovarian and triple-negative breast cancer, targeted by ADCs in clinical trials.