7 articles
CDH1
CDH1 (cadherin 1, HGNC:1748, Gene ID 999) is a human gene at 16q22.1 encoding E-cadherin; germline pathogenic variants cause autosomal dominant diffuse gastric and lobular breast cancer syndrome.
CDH13
CDH13 (T-cadherin, H-cadherin, HGNC:1753) is a human chromosome 16q23.3 gene encoding a GPI-anchored, transmembrane-domain-free cadherin; an adiponectin receptor linked to atherosclerosis, ADHD, and tumor suppression.
CDH2
CDH2 (cadherin 2, N-cadherin, NCAD) is a human protein-coding gene at 18q12.1 encoding a calcium-dependent cell adhesion molecule essential for neural and cardiac development; definitively linked to ACOGS and ADHD.
CDH5
CDH5, also known as VE-cadherin or CD144, is a human gene encoding the endothelial cadherin that forms junctions between vessel-lining cells and controls vascular permeability.
CTNNA1
CTNNA1 (catenin alpha 1, αE-catenin) is a human gene at 5q31.2 encoding a 102-kDa mechanosensing cadherin-actin adaptor; mutations cause butterfly-shaped pigment dystrophy and diffuse gastric/lobular breast cancer syndrome.
CTNND1
CTNND1, or catenin delta 1, is a human gene on chromosome 11 that encodes p120-catenin, which stabilizes cadherins at cell-cell junctions and is often lost in tumors.
FAT1
FAT1 (FAT atypical cadherin 1), human gene at 4q35.2 encoding a 34-cadherin-repeat transmembrane protein; regulates Wnt, Hippo, MAPK signaling; mutated in cancer and recessive nephropathy.