6 articles
AREG
AREG (amphiregulin, AR, SDGF, CRDGF) is a human chromosome 4q13.3 gene encoding a 252-amino-acid EGF-family ligand of EGFR, released by ADAM17 cleavage; it drives tissue repair, type 2 immunity, fibrosis, and cancer, and serves as a biomarker in sepsis and anti-EGFR therapy.
EREG
EREG (epiregulin, EPR) is a human chromosome 4q13.3 gene encoding an EGF-family peptide growth factor that binds EGFR and ErbB4 as a low-affinity, long-acting ligand, released by ADAM17, and implicated in inflammation, wound healing, fibrosis, and cancer progression.
HBEGF
HBEGF (HB-EGF, DTR) is a human EGF-family growth factor gene, secreted by macrophages, mitogenic for smooth muscle cells, and the membrane-anchored receptor for diphtheria toxin.
Neuregulin
Neuregulins (NRG1-NRG4), EGF-family growth factor ligands for ErbB receptor tyrosine kinases, essential in nervous system, heart, and breast development; NRG1 has over 30 isoforms and links to schizophrenia, heart failure therapy, and NRG1-fusion cancers.
Neuregulin-1
Neuregulin-1 (NRG1), chromosome 8p growth factor binding ErbB3/ErbB4; studied as schizophrenia susceptibility gene with mixed association evidence, and NRG1 fusions drive rare solid tumors treated with zenocutuzumab.
TGFA
TGFA (transforming growth factor alpha, TGF-α) is a human gene and EGFR ligand, discovered 1978, cloned 1984, on 2p13.3; shed by ADAM17, linked to cancer and cleft lip/palate.