5 articles
Biogenesis of circular RNA by back-splicing
Biogenesis of circular RNA by back-splicing is the non-canonical splicing that joins a downstream 5′ donor to an upstream 3′ acceptor, closing RNA into a covalent circle.
CDR1 antisense RNA
CDR1 antisense RNA, also known as CDR1as, is a circular RNA from the X chromosome, highly enriched in brain tissue and carrying more than 70 binding sites for miR-7.
Circular RNAs across organisms
Circular RNAs across organisms surveys where covalently closed circRNAs occur across the tree of life, from fungi and plants to vertebrates, and how conserved they are.
Circular RNAs in disease
Circular RNAs (circRNAs), covalently closed non-coding RNAs made by back-splicing, are stable disease-linked biomarker candidates in cancer, cardiovascular, and metabolic disease, with early therapeutic trials but no clinical adoption yet.
Competing endogenous RNA
Competing endogenous RNAs (ceRNAs): transcripts such as lncRNAs, circRNAs, pseudogenes, and mRNAs sharing microRNA response elements that compete for shared miRNAs, forming ceRNET regulatory networks; hypothesis proposed in 2011, with quantitative controversy over physiological scale.