3 articles
Cyclin-dependent kinase 7
Cyclin-dependent kinase 7 (CDK7), with cyclin H and MAT1, forms CAK activating CDKs 1/2/4/6 and is a TFIIH kinase phosphorylating Pol II CTD Ser5/Ser7; targeted by covalent inhibitors THZ1 and YKL-5-124 and clinical candidates ICEC0942, SY-1365, SY-5609, LY3405105.
ERCC2
ERCC2 (XPD) is a human gene on chromosome 19 encoding a 761-amino-acid TFIIH helicase used in transcription initiation and nucleotide excision repair; mutations cause xeroderma pigmentosum, trichothiodystrophy, and overlap syndromes, and somatic mutations mark cisplatin-sensitive bladder cancer.
Transcription factor II H
Transcription factor II H (TFIIH) is a 10-subunit, ~500 kDa eukaryotic complex with XPB translocase and XPD helicase, essential for RNA polymerase II transcription initiation and nucleotide excision repair; mutations cause xeroderma pigmentosum and trichothiodystrophy.