3 articles
Mitochondrial transfer RNA genes
The mitochondrial transfer RNA genes are the 22 tRNA genes in human mitochondrial DNA, which supply the complete adapter set for translating the 13 mitochondrial proteins.
MT-TH
MT-TH (MTTH, TRNH) is the human mitochondrial tRNA histidine gene at NC_012920.1:12138-12206, encoding the tRNA-His adaptor for mitochondrial translation; variants such as m.12201T>C cause mitochondrial disease including deafness.
MT-TK
MT-TK (MTTK, TRNK) is a human mitochondrial DNA gene at NC_012920.1:8295-8364 encoding tRNA-Lys; the m.8344A>G variant causes about 80% of MERRF and other mitochondrial disorders.