3 articles
Heterogeneous nuclear ribonucleoprotein
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a family of RNA-binding proteins that package newly made pre-mRNA in the nucleus and regulate splicing, export, stability, and translation.
HNRP A1 (HNRNPA1)
hnRNP A1 (HNRNPA1), an abundant RNA-binding protein at 12q13.13 with two RRMs, RGG box, and M9 shuttling domain; regulates splicing, telomerase, stress granules, IRES translation; ALS/MSP mutations.
RNA-binding protein FUS
FUS (fused in sarcoma), historically TLS, is an RNA-binding protein regulating transcription, RNA processing, and DNA repair; gene fusions drive liposarcoma, and mutations cause familial ALS.