5 articles
CORDIOPREV trial
CORDIOPREV (NCT00924937): Spanish single-centre randomized trial in 1,002 coronary heart disease patients comparing a Mediterranean diet with a low-fat diet over 7 years; Mediterranean diet reduced major cardiovascular events by 26% (33% in men).
Heart Protection Study
MRC/BHF Heart Protection Study (HPS): UK randomized 2×2 factorial trial of simvastatin 40 mg and antioxidant vitamins in 20,536 high-risk people; simvastatin cut major vascular events 24%, vitamins showed no benefit.
JUPITER trial
JUPITER (Justification for the Use of Statins in Prevention) trial: 2008 AstraZeneca-funded randomized trial of rosuvastatin 20 mg in 17,802 adults with LDL-C under 130 mg/dL and hsCRP at least 2.0 mg/L; stopped at 1.9 years with 44% relative risk reduction, contested absolute benefit, and increased diabetes incidence.
Scandinavian Simvastatin Survival Study
Scandinavian Simvastatin Survival Study (4S), 1994 Lancet trial of simvastatin in 4,444 Nordic coronary heart disease patients; first statin trial to show 30% lower all-cause mortality versus placebo over 5.4 years.
TNT trial (NCT00327691)
TNT (Treating to New Targets, NCT00327691) was a Pfizer-funded randomized trial of atorvastatin 80 mg versus 10 mg daily in 10,001 stable coronary disease patients, showing 22% fewer major cardiovascular events with intensive LDL lowering.