3 articles
Brain metastasis
Brain metastasis: secondary brain cancer spread from a primary tumor, affecting 20-40% of cancer patients; treated with surgery, WBRT, stereotactic radiosurgery, and systemic therapy.
Leptomeningeal carcinomatosis
Leptomeningeal carcinomatosis, also called leptomeningeal metastasis or neoplastic meningitis, is spread of cancer cells within the leptomeninges and subarachnoid space, affecting about 5% of cancer patients, most often from breast, lung cancer, or melanoma, diagnosed by CSF cytology and MRI.
OWBLM trial
OWBLM (NCT04425681) is a phase II single-arm trial of osimertinib 80 mg daily plus bevacizumab 7.5 mg/kg for leptomeningeal metastasis from EGFR-mutant NSCLC; 14 patients, median LM PFS 9.3 months, ORR 50%, LM OS 12.6 months.