17 articles
Antineoplastic Protocols
Antineoplastic Protocols (Cancer Treatment Protocols) are clinical protocols to inhibit growth or spread of neoplasms; a MeSH descriptor D024221 introduced in 2002, covering combination cancer treatment plans and guideline adherence.
Chemotherapy, Cancer, Regional Perfusion
Chemotherapy, cancer, regional perfusion (MeSH D010478): cancer drug therapy via an extracorporeal circuit isolating the tumor-bearing area, chiefly isolated limb perfusion with melphalan and TNFα for extremity melanoma and sarcoma, delivering 10-20 times systemic doses.
HAICI trial
HAICI (NCT06741020), Hepatic Arterial Infusion Chemotherapy and Immunotherapy for Hepatocellular Carcinoma, a phase 1/2 single-arm pilot neoadjuvant trial at Zhejiang Cancer Hospital testing FOLFOX-HAIC plus adebrelimab in resectable BCLC A/B HCC.
Hepatic arterial infusion
Hepatic arterial infusion is a regional chemotherapy method that infuses cytotoxic drugs through a catheter in the hepatic artery, mainly for unresectable colorectal liver metastases and cholangiocarcinoma.
Implantable Infusion Pumps
Implantable infusion pumps (implantable intrathecal drug delivery systems): surgically implanted, self-powered pumps delivering chemotherapy or analgesics at controlled rates; first morphine pump 1981, SynchroMed II most used, ~1% flow error, 5.9-year battery life.
Intra-arterial chemotherapy
Intra-arterial chemotherapy (IAC) is a cancer treatment delivering drugs directly into the artery feeding a tumor, used chiefly for liver tumors via hepatic artery infusion and for retinoblastoma.
Intraperitoneal chemotherapy
Intraperitoneal chemotherapy is a cancer treatment delivering cytotoxic drugs directly into the peritoneal cavity, giving higher drug exposure to abdominal tumors than intravenous therapy, notably in ovarian cancer.
Intrathecal chemotherapy
Intrathecal chemotherapy, including triple intrathecal chemotherapy, injects cancer drugs directly into the cerebrospinal fluid of the spinal canal or brain ventricles, treating or preventing CNS malignancy.
Intraventricular infusion
Intraventricular infusion, also called intracerebroventricular (ICV) administration, delivers drugs directly into the brain's cerebrospinal fluid through a catheter and reservoir, bypassing the blood–brain barrier for chemotherapy, antibiotics, enzyme replacement, and gene therapy.
Intravesical administration
Intravesical administration is a drug delivery method in which liquid medication is instilled into the bladder via catheter, chiefly to treat non-muscle-invasive bladder cancer with mitomycin C or BCG.
Intravesical chemotherapy
Intravesical chemotherapy is a bladder cancer treatment in which a cytotoxic drug, such as mitomycin C, is instilled through a catheter to treat non-muscle invasive tumors.
Outpatient parenteral antibiotic therapy
Outpatient parenteral antibiotic therapy (OPAT) is the delivery of intravenous antibiotics outside the hospital, treating about 250,000 US patients yearly for infections like endocarditis and osteomyelitis.
Outpatient parenteral antimicrobial therapy
Outpatient parenteral antimicrobial therapy (OPAT) is the administration of intravenous antimicrobial drugs outside the hospital, treating serious infections such as osteomyelitis and endocarditis at home or in infusion centers.
Photothermal chemotherapy
Photothermal chemotherapy is a combination cancer treatment in which near-infrared light heats a tumor while a chemotherapeutic drug acts on the same tissue, usually via one nanoparticle.
Regional chemotherapy
Regional chemotherapy is a cancer treatment that delivers anticancer drugs directly into the arteries supplying a tumor region, concentrating drug exposure while limiting toxicity to the rest of the body.
Thrombolysis
Thrombolysis is the pharmacological dissolution of blood clots by drugs that convert plasminogen to plasmin, used for acute ischemic stroke within 4.5 hours and pulmonary embolism.
Thrombolytic therapy
Thrombolytic therapy is treatment with clot-dissolving drugs such as alteplase and tenecteplase, given intravenously to break up clots in stroke, heart attack, and pulmonary embolism.