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Histopathology and tissue-based diagnostics

8 articles

Adrenal vein sampling

Adrenal vein sampling is an interventional radiology procedure that draws blood from the adrenal veins to determine which gland causes primary aldosteronism, guiding adrenalectomy; it has been used for over 50 years.

Biodosimetry

Biodosimetry estimates a person's absorbed radiation dose by measuring biological markers, most often chromosome aberrations in blood lymphocytes, using calibration curves; the dicentric assay has been the gold standard since the mid-1960s.

Circulating tumor DNA analysis

Circulating tumor DNA analysis is a liquid biopsy method that detects tumor-derived DNA fragments in blood to guide cancer treatment, monitor recurrence, and screen for cancer.

Gross examination

Gross examination, or grossing, is the bare-eye inspection, description, measurement, and sampling of surgical specimens in a pathology laboratory before microscopic processing, so the right tissue reaches the histologist.

Measurable residual disease detection

Measurable residual disease detection is a set of highly sensitive laboratory assays that count the few malignant cells remaining in bone marrow or blood after treatment.

Prussian Blue Reaction

The Prussian blue reaction, also known as Perls' stain or the iron stain, is a histochemical technique that detects ferric iron in tissues, described by Max Perls in 1867.

Thrombin generation assay

The thrombin generation assay (TGA) is a laboratory hemostasis test measuring how much thrombin plasma produces over time after coagulation is triggered, assessing both bleeding and clotting risk.

Urine culture

Urine culture is a laboratory test that grows and counts microbes from a urine sample to identify the organism causing a urinary tract infection and its antibiotic susceptibilities.