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Liquid biopsy and circulating biomarkers

9 articles

Bone histomorphometry

Bone histomorphometry is a quantitative microscopy method measuring bone structure, cellular activity, and formation and resorption rates in an undecalcified bone biopsy, usually from the iliac crest.

Cell-free DNA analysis

Cell-free DNA analysis detects short DNA fragments circulating freely in blood and other body fluids, used in prenatal screening, cancer detection and monitoring, and transplant surveillance.

ctDNA monitoring

CtDNA monitoring is a liquid-biopsy method that repeatedly measures tumor-derived DNA fragments in blood plasma to track tumor burden over time, detecting colorectal cancer recurrence a mean 8.7 months before imaging.

Fractional exhaled nitric oxide testing

Fractional exhaled nitric oxide (FeNO) testing is a noninvasive breath test measuring eosinophilic airway inflammation in parts per billion at a standardized flow, used to support asthma diagnosis and guide corticosteroid therapy.

Hepatocellular ballooning

Hepatocellular ballooning is a liver biopsy finding in which injured hepatocytes become markedly swollen with rarefied cytoplasm from keratin 8/18 cytoskeleton collapse, a required feature for diagnosing steatohepatitis.

Inulin clearance

Inulin clearance is a renal function test that measures the rate at which the kidneys remove inulin from plasma, long considered the gold standard for measuring glomerular filtration rate.

Multigene panel testing

Multigene panel testing is a diagnostic genetic test that sequences many genes linked to one condition in a single assay, used to assess hereditary cancer risk and guide treatment.

Platelet function testing

Platelet function testing, also called platelet function tests, is a group of laboratory assays measuring platelet aggregation and activation to diagnose bleeding disorders and monitor antiplatelet drug effects.

Protein-to-creatinine ratio

The protein-to-creatinine ratio, validated in 1983, is a urine test that estimates 24-hour protein excretion from a single sample, with about 3.1 mg/mg indicating nephrotic-range proteinuria.