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Biopsy techniques

45 articles

Breast duct lavage

Breast duct lavage, also known as ductal lavage, is a diagnostic procedure that flushes fluid from the milk ducts through the nipple to collect epithelial cells for cytologic examination.

Cervical biopsy

A cervical biopsy is a procedure that samples tissue from the cervix to check for precancer or cancer, usually done during colposcopy after an abnormal screening result.

Cold knife cone biopsy

Cold knife cone biopsy, or cold knife conization, is a gynecologic procedure that removes a cone of cervical tissue with a scalpel to diagnose and treat precancerous lesions.

Core needle biopsy

Core needle biopsy is a percutaneous procedure in which a hollow cutting needle, typically 9 to 20 gauge, removes a small cylinder of tissue for histologic examination, preserving tissue architecture.

Cryobiopsy

Cryobiopsy, or transbronchial mediastinal cryobiopsy, is a biopsy technique in which a cryoprobe freezes tissue to withdraw an intact specimen, with about 81% diagnostic yield for interstitial lung disease.

CT-guided biopsy

CT-guided biopsy is a percutaneous diagnostic procedure in which computed tomography guides a needle into a suspected lesion to obtain tissue samples, first reported in 1976.

Endocervical curettage

Endocervical curettage is a gynecological diagnostic procedure that scrapes the endocervical canal for a tissue sample during colposcopy, detecting precancerous or cancerous disease the colposcope cannot see.

Endometrial sampling

Endometrial sampling is an office gynecological procedure that removes a small piece of the uterine lining, usually with a Pipelle suction device, to diagnose cancer, hyperplasia, and abnormal bleeding.

Endoscopic biopsy

Endoscopic biopsy is a diagnostic procedure in which small tissue samples are removed through an endoscope's working channel and examined microscopically to detect inflammation, dysplasia, and cancer.

Esophageal biopsy

An esophageal biopsy is a tissue sample taken from the esophageal lining, usually with forceps passed through an endoscope, to diagnose eosinophilic esophagitis, infections, Barrett's esophagus, and cancer.

Forceps biopsy

Forceps biopsy is a diagnostic procedure in which cupped forceps passed through an endoscope cut small tissue samples from the gastrointestinal or biliary mucosa for examination.

Fusion prostate biopsy

Fusion prostate biopsy is a targeted technique that registers pre-procedure prostate MRI with real-time ultrasound so urologists can aim needles at MRI-visible suspicious lesions, one of three common MRI-targeted biopsy techniques.

Image-guided biopsy

Image-guided biopsy is a procedure in which a needle is placed into a suspected lesion under real-time imaging, such as ultrasound or CT, to obtain cells or tissue for diagnosis.

Impression cytology

Impression cytology is a minimally invasive ophthalmology technique, introduced in 1977, that presses a filter membrane against the eye to collect superficial epithelial cells for cytological, immunological, or molecular examination.

Incisional biopsy

Incisional biopsy, contrasted with excisional biopsy, is a surgical diagnostic procedure removing only part of a lesion, used when malignancy needs tissue diagnosis before definitive surgery.

Lymph node biopsy

A lymph node biopsy removes all or part of a lymph node, by needle or surgery, so the tissue can be examined to diagnose cancer, infection, and other nodal disease.

Lymph node sampling

Lymph node sampling removes lymph node tissue to obtain a histopathologic diagnosis and assign a TNM nodal (N) stage, most often for staging lung and breast cancer.

Mapping biopsy

A mapping biopsy is a diagnostic technique that takes systematically spaced, recorded cores across an organ, most often the prostate, to map lesion location and grade.

Minimally invasive biopsy

A minimally invasive biopsy removes cells or small tissue samples through a needle or a natural body opening, without open surgery, to test for disease.

MRI-ultrasound fusion biopsy

MRI-ultrasound fusion biopsy, also known as ultrasound fusion biopsy, is a prostate biopsy technique that co-registers a pre-biopsy MRI scan onto real-time ultrasound, letting urologists target MRI-visible lesions directly.

Needle biopsy

Needle biopsy is a diagnostic procedure in which a hollow needle, usually guided by imaging, removes cells or tissue from a suspected lesion for microscopic examination.

Prostate biopsy

A prostate biopsy is a diagnostic procedure that removes small prostate tissue samples with a needle, usually guided by ultrasound or MRI, to diagnose prostate cancer.

Punch biopsy

Punch biopsy is a skin biopsy technique in which a rotating hollow blade removes a small cylindrical core of skin, from epidermis to subcutaneous fat, for diagnosis.

Rapid autopsy

Rapid autopsy, also known as rapid research autopsy or a warm autopsy, is a research procedure that collects tissue within hours of death, mostly to sample metastatic cancer comprehensively.

Rectal biopsy

A rectal biopsy is a diagnostic procedure removing a small sample of rectal mucosa for histological examination, chiefly to diagnose or exclude Hirschsprung disease, first reported in 1955.

Salivary gland biopsy

Salivary gland biopsy is a diagnostic procedure that removes small samples of salivary gland tissue, usually from the lower lip, to examine histologically, chiefly for Sjögren's disease.

Sentinel lymph node biopsy

Sentinel lymph node biopsy (SLNB), or sentinel node biopsy, is a surgical staging procedure that removes the first lymph node draining a tumor to check for cancer spread.

Sextant biopsy

Sextant biopsy is a systematic prostate biopsy protocol taking six transrectal ultrasound-guided cores, three per side at apex, mid-gland, and base, described in 1989 and later replaced by 12-core schemes.

Shave biopsy

A shave biopsy is a skin biopsy technique that slices a thin layer off a lesion with a blade, the most commonly used skin biopsy method.

Skin biopsy

A skin biopsy is a diagnostic procedure in which a small sample of skin is removed, usually under local anesthesia, and examined microscopically to diagnose skin diseases and systemic conditions with skin manifestations.