26 articles
AGuIX
AGuIX (Activation and Guidance of Irradiation by X-ray) is a 5 nm gadonium-based nanoparticle developed by NH TherAguix in France as an MRI contrast agent and X-ray radiosensitizer for tumors.
Cherenkov luminescence imaging
Cherenkov luminescence imaging is an optical method that photographs the faint light emitted when radioactive tracers decay in tissue, a low-cost complement to PET and SPECT.
Diffuse optical imaging
Diffuse optical imaging (DOI) is a biomedical imaging technique using near-infrared light to reconstruct maps of hemoglobin, oxygenation, and blood flow in tissue several centimeters deep.
Diffuse optical tomography
Diffuse optical tomography (DOT) is a medical imaging method that reconstructs 3-D maps of near-infrared light absorption in thick tissue, applied to breast tumors and brain function.
Electrical impedance tomography
Electrical impedance tomography (EIT) is a non-invasive, radiation-free imaging method that reconstructs the body's internal electrical conductivity from electrodes on the skin, giving real-time images of regional lung ventilation at the bedside.
Electrocardiographic imaging
Electrocardiographic imaging (ECGI) is a noninvasive mapping method that reconstructs the heart's electrical activity from body-surface ECGs and CT geometry, used to locate arrhythmias before ablation.
Electron paramagnetic resonance imaging
Electron paramagnetic resonance imaging (EPRI, also called EPR imaging or EPROI) is a biomedical imaging method that maps paramagnetic probes in tissue to measure oxygen and redox status.
Fluorescence molecular tomography
Fluorescence molecular tomography, also called fluorescence tomography, is an optical imaging method that reconstructs 3D distributions of fluorescent probes inside living tissue from surface measurements.
Fusion imaging
Fusion imaging is a medical imaging technique that overlays real-time ultrasound with previously acquired CT, MRI, or PET/CT, guiding biopsies and tumor ablations without radiation.
Hybrid imaging
Hybrid imaging is a medical imaging approach combining an anatomical scan (CT or MRI) with a functional scan (PET or SPECT), with main pairs PET/CT, PET/MRI, and SPECT/CT.
Intraoperative molecular imaging
Intraoperative molecular imaging (IMI) is a surgical technique in which fluorescent tracers given before or during surgery make tumor tissue light up in the operating field.
Magnetic particle imaging
Magnetic particle imaging (MPI) is a radiation-free tomographic method that images iron oxide nanoparticle tracers in the body, reported by Gleich and Weizenecker in 2005.
Microwave Imaging
Microwave imaging, also called microwave tomography, is a non-ionizing diagnostic technique using 500 MHz–10 GHz waves and tissue dielectric contrast, aimed mainly at breast cancer and stroke detection; still pre-commercial.
Near-infrared II fluorescence imaging
Near-infrared II fluorescence imaging is an optical technique using 1,000–1,700 nm fluorescent probes to image deep tissue, such as blood vessels and tumors, with high resolution.
Pafolacianine
Pafolacianine (Cytalux, OTL-38) is a folate receptor-targeted near-infrared fluorescent imaging agent injected before surgery; FDA-approved in 2021 for ovarian cancer and 2022 for lung lesion identification.
PET-MR imaging
PET-MR imaging is a hybrid modality acquiring PET and MRI data in one examination, useful for brain, prostate, cardiac, and pediatric imaging with lower radiation dose.
PET-MRI
PET-MRI is a hybrid medical imaging method that acquires PET and MRI in a single scanner, improving diagnostic accuracy over PET/CT while greatly lowering radiation dose.
Photoacoustic nanoprobes
Photoacoustic nanoprobes are nanoparticles, typically tens to hundreds of nanometers, that serve as contrast agents in photoacoustic imaging, adding molecular specificity and functional readouts beyond endogenous absorbers like hemoglobin.
Photoacoustic Techniques
Photoacoustic techniques (optoacoustic techniques) are diagnostic and investigative methods using sound waves generated by absorption of electromagnetic radiation, chiefly laser-based biomedical imaging combining optical contrast with ultrasound resolution, from Bell's 1880 effect to PACT and PAM systems.
Photoacoustic tomography
Photoacoustic tomography, also called photoacoustic computed tomography, is a biomedical imaging method combining ultrasound resolution with optical contrast from hemoglobin, reaching centimeter depths for breast cancer imaging.
Relmapirazin
Relmapirazin (MB-102, Lumitrace) is a 372 Da fluorescent pyrazine tracer, cleared solely by glomerular filtration, used intravenously with the MediBeacon transdermal system for point-of-care GFR measurement; FDA approved 2025, validated against iohexol (r²=0.99), also studied orally for gut permeability.
SPECT/CT
SPECT/CT is a hybrid nuclear medicine imaging method combining SPECT functional radiotracer images with CT anatomical images for localization and attenuation correction, first commercialized in 1999.
Terahertz imaging
Terahertz imaging is a medical imaging technique that uses 0.1–5 THz radiation, strongly absorbed by water, to distinguish diseased from healthy tissue, chiefly in skin cancer.
Ultrasound computed tomography
Ultrasound computed tomography, or ultrasound tomography, is an imaging method that reconstructs cross-sectional maps of tissue sound speed and attenuation, developed mainly for breast cancer screening.
X-ray luminescence computed tomography
X-ray luminescence computed tomography (XLCT) is a hybrid imaging method, reported by Guillem Pratx and colleagues in 2010, that maps x-ray-excited luminescent nanoparticles inside an object from surface optical measurements.
Zirconium Zr-89 girentuximab (Zircaix)
Zirconium Zr-89 girentuximab (Zircaix, TLX250-CDx, 89Zr-DFO-girentuximab) is a zirconium-89-labeled anti-CAIX antibody for PET/CT imaging of clear cell renal cell carcinoma; ZIRCON phase 3 showed 85.5% sensitivity and 87.0% specificity.