32 articles
ABroProMida trial
ABroProMida (NCT06736938; EU CT 2024-518820-65-00) is a single-center Italian randomized trial comparing propofol/pethidine versus midazolam/pethidine sedation in 530 adults undergoing elective bronchoscopy, with desaturation index as the primary endpoint.
ANGLE trial
ANGLE trial (NCT07223762), Hyperangulated Versus Standard Geometry Laryngoscope Blade Trial: Vanderbilt-sponsored randomized trial in 2,500 critically ill ED and ICU adults comparing first-attempt intubation success and hypoxemia between hyperangulated and standard geometry video laryngoscope blades.
BRECHE trial
BRECHE (NCT07354464) is a phase 3 randomized trial at CHU Clermont-Ferrand, France, comparing sphenopalatine ganglion block with epidural blood patch for post-dural puncture headache; 80 participants, started February 2026, completion expected February 2028.
CAN trial
CAN trial (Cancer and Anesthesia study, NCT01975064): Swedish-led pragmatic RCT comparing propofol-based with sevoflurane-based general anesthesia for radical breast and colorectal cancer surgery; breast cohort (1,670 analyzed) found no five-year survival difference.
DICEE trial
DICEE trial (Deflated and Inflated Cuff Endotracheal Extubations, NCT06990308): a single-center blinded randomized trial at Naval Medical Center Camp Lejeune comparing deflated versus inflated cuff extubation in 88 healthy adults after non-airway surgery, using contrast chest radiography to detect airway contamination.
DIMAN study
DIMAN (NCT02680327) is a prospective observational feasibility pilot at the Montreal Heart Institute testing recruitment and retention of elderly cardiac surgery patients for a multicenter audit of advance care planning practices and end-of-life communication satisfaction, using CANHELP questionnaires and 5-meter gait speed frailty assessment.
ERAS trial
ERAS trial (NCT05511194): single-blind randomized trial of a modified Enhanced Recovery After Surgery protocol for pediatric complicated appendicitis in Guadalajara, Mexico; 40 children; shorter stay (3.15 vs 5.20 days) without added morbidity.
ESPOK trial
The ESPOK trial is a randomized controlled trial at Vinmec Healthcare System in Vietnam comparing erector spinae plane catheters with thoracic epidural analgesia after minimally invasive esophageal cancer surgery.
HILUTS trial
HILUTS trial (NCT03633994), a phase 2 randomized quadruple-masked trial at The Christ Hospital, Cincinnati, testing intraoperative heparin bladder instillation (40,000 U) versus saline to reduce lower urinary tract symptoms after benign hysterectomy; no results posted.
ICE trial (NCT05731973)
The ICE trial (NCT05731973) was a Dutch randomized trial comparing intercostal nerve cryoablation with thoracic epidural analgesia for pain control after the Nuss procedure for pectus excavatum.
ICONE trial
ICONE trial (NCT05699005), a French multicenter randomized trial from University Hospital, Lille, comparing individualized ScvO2-triggered versus conventional hemoglobin <9 g/dL red cell transfusion in adults on VA-ECMO for refractory cardiogenic shock; 236 patients, recruiting.
Imacor-1 study
Imacor-1 (NCT02770183) was a withdrawn Geneva observational study of post-cardiac-surgery myocardial stunning recovery measured with the ImaCor ClariTEE hTEE probe; enrolled 0 participants.
Intra-Op trial
Intra-Op trial (NCT04182997), a Phase 4 randomized trial by University of Missouri-Columbia testing intraoperative epidural dexamethasone versus saline after lumbar discectomy, with nerve-root inflammation grading, 200 participants, recruiting since 2019.
Kel-Load trial
Kel-Load trial: Malaysian randomised double-blind trial (64 patients) testing Kelulut stingless bee honey versus Carborie maltodextrin for pre-operative carbohydrate loading in elective intra-abdominal surgery, with equivalent glucose, gastric, and recovery outcomes.
MILAN trial
MILAN (NCT05450328) is a multicenter double-blind randomized trial at the Montreal Heart Institute testing inhaled epoprostenol 60 mcg plus milrinone 4 mg versus placebo before cardiopulmonary bypass to prevent difficult bypass weaning in 142 cardiac surgery patients.
MMCS trial
MMCS trial (NCT04442672), a completed 2019 interventional study by Zhejiang University's Second Affiliated Hospital, tested tissue oxygen, ultrasound Doppler, thermography, and pulse oximetry against cuff-induced calf pressure in healthy volunteers.
NDCVC-01 trial
NDCVC-01 (NCT06652191), Non Dilation on the Central Venous Catheterization, a randomized non-inferiority trial at Sun Yat-sen University's Sixth Affiliated Hospital testing omission of the skin-dilation step in internal jugular CVC insertion in 336 patients.
OSGA trial
OSGA trial (NCT02619214), a phase 4 randomized Barcelona trial comparing 30% vs 60% inspired oxygen during one hour of sevoflurane general anesthesia, measuring malondialdehyde and other oxidative stress markers in healthy surgical patients.
POPEYE trial
The POPEYE trial is a randomized controlled trial at IRCCS Policlinico San Donato in Italy comparing epidural analgesia with rectus sheath block after open abdominal aortic aneurysm repair.
PPV-CVP-FLUID study
PPV-CVP-FLUID is a randomized trial comparing pulse pressure variation versus central venous pressure guidance for intraoperative fluid management in intracranial tumor surgery; 60 patients, PPV group had better hemodynamic stability and less postoperative fluid.
PRE-EXELUCA trial
PRE-EXELUCA (NCT06215326) is a randomized controlled trial by Guangdong Provincial People's Hospital comparing intensities of preoperative exercise training in 100 moderate-to-high perioperative risk lung cancer patients before lung resection, measuring cardiopulmonary function and postoperative outcomes.
PREDICTION trial
PREDICTION (NCT06729827) is a completed single-center randomized trial at Gemelli IRCCS, Rome, testing Hypotension Prediction Index-guided norepinephrine versus standard monitoring to reduce post-spinal hypotension during elective cesarean section in 102 women.
PROTOP trial
PROTOP (NCT03574090) is a completed phase 4, triple-blind randomized Spanish trial by Universitat Internacional de Catalunya testing topical amoxicillin-clavulanic acid wound irrigation versus saline to prevent incisional surgical site infection in colorectal surgery; distinct from the tacrolimus ointment PROTOPIC.
QUANTRANS trial
QUANTRANS (NCT05798286) was a French multicenter randomized trial testing Quantra viscoelastic test-guided transfusion versus standard coagulation tests in double-lung transplantation; 128 patients, no reduction in transfusion (p = 0.923).
RAACU trial
RAACU (NCT06002464) is a Vinmec-sponsored, open-label randomized trial in Hanoi testing whether acupuncture added to bilateral continuous erector spinae plane block improves post-hysterectomy pain relief, opioid use, and recovery in 72 women.
RCT-PIDST trial
RCT-PIDST (NCT07712328) is a Phase 4 randomized trial at Huashan Hospital, Shanghai, testing prophylactic intraoperative desmopressin infusion to prevent hypernatremia after complex sellar region tumor surgery in 152 patients.
SECURE study
SECURE (Clinical Outcomes in Patients Treated With SternaLock Blu, NCT03709693) was a terminated Zimmer Biomet real-world evidence study of deep sternal wound infection at 30 days after SternaLock Blu rigid plate sternotomy closure, targeting 156 participants at four US sites.
tDCS trial (NCT02549560)
NCT02549560 (tDCS trial): University of Sao Paulo randomized, triple-masked trial of transcranial direct current stimulation, 2 mA over the right prefrontal cortex, to prevent postoperative cognitive dysfunction after cardiac surgery; 138 participants, registered 2015, completed November 2023.
TMGS trial
TMGS (NCT01655641) was a suspended randomized trial at Tribhuvan University Teaching Hospital, Nepal, testing perioperative tranexamic acid (1 g preoperative, then 10 mg/kg 8-hourly for 5 days) for reducing transfusion in 118 patients undergoing major gastrointestinal surgery.
TQL trial
TQL trial (NCT05349656), a completed Alexandria University randomized quadruple-masked trial comparing transmuscular quadratus lumborum block versus PENG block for postoperative analgesia in 40 children aged 1 to 6 undergoing open hip surgery for developmental dysplasia of the hip.